The Surgical Benefits of Repeat Hepatectomy for Colorectal Liver Metastasis

The most common site of distant metastasis from colorectal cancer is the liver, and hepatectomy presents the best curative treatment for recurrence of colorectal liver metastasis （CRLM）. This study aimed to identify factors of prognostic value for repeat hepatectomy for CRLM and to determine whether a third such procedure could similarly produce favourable outcomes for CRLM. We analyzed data for 161 patients in our department with colorectal metastasis. Of these, 22 patients underwent repeat hepatectomy for recurrent metastasis, with 16 undergoing a second hepatectomy and 6 a third hepatectomy. We analyzed patient characteristics, tumor status, operation-related variables, and short- and long-term outcomes. Univariate analysis for repeat hepatectomy identified the following five prognostic risk factors: T factor （＞SE） of the primary cancer, number of tumors involved in the initial hepatectomy （＞5）, interval from first to second hepatectomy （＜1year）, number of tumors involved in second hepatectomy （＞3）, and post-operation time （＞30days）. By multivariate analysis, T factor （＞SE） of the primary cancer, number of tumors in the initial hepatectomy （＞5）, and number of tumors in the second hepatectomy （＞3） were independently associated with a worse survival after surgery for CRLM. Although surgical outcomes of the third hepatectomy were not compared with those of the first and second hepatectomy, there were no obvious differences, nor did the 1-, 3-, and 5-year survival rates differ significantly among the three groups. Repeat hepatectomy for CRLM could improve long-term survival. In addition, patients undergoing a third hepatectomy showed a similar survival benefit to those having one or two resections

Characteristics of the BDNF Val66Met polymorphism in competitive swimmers and judo athletes

Studies have demonstrated that motivation, aggression, excitation intensity, competitive spirit, and tolerance to psychological stress are included in major psychological factors affecting the performance of athletes. However, to date, there have not been sufficient scientific studies on the relationship between genetic polymorphisms affecting psychological abilities and competitive strength/sport. In this study, we compared the distribution of the brain-derived neurotrophic factor (BDNF) gene polymorphism(Val66Met) in athletes between competitive swimming, which needs closed skill without opponents, and judo, which needs open skill with opponents, in order to investigate the genetic basis of sports performance and related psychological factors. The results showed that the prevalence of Met carriers of the BDNF polymorphism associated with vulnerability to psychological stress was lower in judo players, suggesting that judo athletes had a higher stress tolerance. In addition, the prevalence of the BDNFheterozygous group was higher in competitive swimmers, supporting the hypothesis that closed skill sports without opponents receive less stress than open skill sports with opponents, furthre suggesting that they are excellent in motor control and motor learning

Characteristics of the BDNF Val66Met polymorphism in competitive swimmers and judo athletes

Studies have demonstrated that motivation, aggression, excitation intensity, competitive spirit, and tolerance to psychological stress are included in major psychological factors affecting the performance of athletes. However, to date, there have not been sufficient scientific studies on the relationship between genetic polymorphisms affecting psychological abilities and competitive strength/sport. In this study, we compared the distribution of the brain-derived neurotrophic factor (BDNF) gene polymorphism(Val66Met) in athletes between competitive swimming, which needs closed skill without opponents, and judo, which needs open skill with opponents, in order to investigate the genetic basis of sports performance and related psychological factors. The results showed that the prevalence of Met carriers of the BDNF polymorphism associated with vulnerability to psychological stress was lower in judo players, suggesting that judo athletes had a higher stress tolerance. In addition, the prevalence of the BDNF heterozygous group was higher in competitive swimmers, supporting the hypothesis that closed skill sports without opponents receive less stress than open skill sports with opponents, furthre suggesting that they are excellent in motor control and motor learning