Brugada syndrome during physical therapy: a case report

This case report describes about a young, male patient with persisting syncope during physical therapy for complex regional pain syndrome type 1 after metatarsal fractures

Acceleration of the direct identification of Staphylococcus aureus versus coagulase-negative staphylococci from blood culture material: a comparison of six bacterial DNA extraction methods

To accelerate differentiation between Staphylococcus aureus and coagulase-negative staphylococci (CNS), this study aimed to compare six different DNA extraction methods from two commonly used blood culture materials, i.e. BACTEC and BacT/ALERT. Furthermore, we analysed the effect of reduced blood culture incubation for the detection of staphylococci directly from blood culture material. A real-time polymerase chain reaction (PCR) duplex assay was used to compare the six different DNA isolation protocols on two different blood culture systems. Negative blood culture material was spiked with methicillin-resistant S. aureus (MRSA). Bacterial DNA was isolated with automated extractor easyMAG (three protocols), automated extractor MagNA Pure LC (LC Microbiology Kit MGrade), a manual kit MolYsis Plus and a combination of MolYsis Plus and the easyMAG. The most optimal isolation method was used to evaluate reduced bacterial incubation times. Bacterial DNA isolation with the MolYsis Plus kit in combination with the specific B protocol on the easyMAG resulted in the most sensitive detection of S. aureus, with a detection limit of 10 CFU/ml, in BacT/ALERT material, whereas using BACTEC resulted in a detection limit of 100 CFU/ml. An initial S. aureus or CNS load of 1 CFU/ml blood can be detected after 5 h of incubation in BacT/ALERT 3D by combining the sensitive isolation method and the tuf LightCycler assay

Management control systems in innovation companies: A literature based framework

Past research has traditionally argued that management control systems (MCSs) may present a hindrance to the creativity of innovation companies. This theoretical paper surveys the literature to focus an investigation on the MCSs of innovation companies. Within the object of control paradigm the paper develops and presents a theoretical model of the impact of eleven external, organisational and innovation related contingency factors on the MCSs in companies that engage in innovation activities. We also suggest measures for further empirical research. By formulating hypotheses on 43 potential interactions the model predicts contradictory influences on two direct control categories, results and action control, but stresses the importance of two indirect categories, personnel and cultural control. More specifically, the high levels of technological complexity and innovation capability in this type of company are expected to be negatively associated with the application of results and action control, whereas personnel and cultural seem to be more appropriate. Furthermore, important sources of finance, venture capital and public funding, are both hypothesised to be positively associated with the application of results, action and personnel control; whereas only public funding is predicted to be positively related to the application of cultural control. The principal contribution of this paper lies in synthesising the literature to provide a model of the impact of a unique set of eleven contingency factors for innovation companies on a broad scope of controls. In addition, the contingency model, if empirically validated, would add value by inferring the particular forms of management control which would be beneficial in innovative company settings. © 2014 Springer-Verlag Berlin Heidelberg

Adaptive flood risk management planning based on a comprehensive flood risk conceptualisation

Densely populated deltas are so vulnerable to sea level rise and climate change that they cannot wait for global mitigation to become effective. The Netherlands therefore puts huge efforts in adaptation research and planning for the future, for example through the national research programme Knowledge for Climate and the Delta Programme for the Twenty-first century. Flood risk is one of the key issues addressed in both programmes. Adaptive management planning should rely on a sound ex-ante policy analysis which encompasses a future outlook, establishing whether a policy transition is required, an assessment of alternative flood risk management strategies, and their planning in anticipation without running the risk of regret of doing too little too late or too much too early. This endeavour, addressed as adaptive delta management, calls for new approaches, especially because of uncertainties about long-term future developments. For flood risk management, it also entails reconsideration of the underlying principles and of the application of portfolios of technical measures versus spatial planning and other policy instruments. To this end, we first developed a conceptualisation of flood risk which reconciles the different approaches of flood defence management practice and spatial planning practice in order to bridge the gap between these previously detached fields. Secondly, we looked abroad in order to be better able to reflect critically on a possible Dutch bias which could have resulted from many centuries of experience of successful adaptation to increasing flood risk, but which may no longer be sustainable into the future. In this paper, we explain the multiple conceptualisation of flood risk and argue that explicitly distinguishing exposure determinants as a new concept may help to bridge the gap between engineers and spatial planners, wherefore we show how their different conceptualisations influence the framing of the adaptation challenge. Also, we identify what the Netherlands may learn from neighbouring countries with a different framing of the future flood risk challenge