The Kuiper Belt and Other Debris Disks

We discuss the current knowledge of the Solar system, focusing on bodies in the outer regions, on the information they provide concerning Solar system formation, and on the possible relationships that may exist between our system and the debris disks of other stars. Beyond the domains of the Terrestrial and giant planets, the comets in the Kuiper belt and the Oort cloud preserve some of our most pristine materials. The Kuiper belt, in particular, is a collisional dust source and a scientific bridge to the dusty "debris disks" observed around many nearby main-sequence stars. Study of the Solar system provides a level of detail that we cannot discern in the distant disks while observations of the disks may help to set the Solar system in proper context.Comment: 50 pages, 25 Figures. To appear in conference proceedings book "Astrophysics in the Next Decade

Emerging role of insulin with incretin therapies for management of type 2 diabetes

Type 2 diabetes mellitus (T2DM) is a progressive disease warranting intensification of treatment, as beta-cell function declines over time. Current treatment algorithms recommend metformin as the first-line agent, while advocating the addition of either basal-bolus or premixed insulin as the final level of intervention. Incretin therapy, including incretin mimetics or enhancers, are the latest group of drugs available for treatment of T2DM. These agents act through the incretin axis, are currently recommended as add-on agents either as second-or third-line treatment, without concurrent use of insulin. Given the novel role of incretin therapy in terms of reducing postprandial hyperglycemia, and favorable effects on weight with reduced incidence of hypoglycemia, we explore alternative options for incretin therapy in T2DM management. Furthermore, as some evidence alludes to incretins potentially increasing betacell mass and altering disease progression, we propose introducing these agents earlier in the treatment algorithm. In addition, we suggest the concurrent use of incretins with insulin, given the favorable effects especially in relation to weight gain

Measurements of electron anisotropy in solar flares using albedo with RHESSI X-ray data

The angular distribution of electrons accelerated in solar flares is a key parameter in the understanding of the acceleration and propagation mechanisms that occur there. However, the anisotropy of energetic electrons is still a poorly known quantity, with observational studies producing evidence for an isotropic distribution and theoretical models mainly considering the strongly beamed case. We use the effect of photospheric albedo to infer the pitch-angle distribution of X-ray emitting electrons using Hard X-ray data from RHESSI. A bi-directional approximation is applied and a regularised inversion is performed for eight large flare events to deduce the electron spectra in both downward (towards the photosphere) and upward (away from the photosphere) directions. The electron spectra and the electron anisotropy ratios are calculated for a broad energy range, from about ten up to ∼ 300 keV, near the peak of the flares. The variation of electron anisotropy over short periods of time lasting 4, 8 and 16 seconds near the impulsive peak has been examined. The results show little evidence for strong anisotropy and the mean electron flux spectra are consistent with the isotropic electron distribution. The 3σ level uncertainties, although energy and event dependent, are found to suggest that anisotropic distribution with anisotropy larger than ∼ three are not consistent with the hard X-ray data. At energies above 150 – 200 keV, the uncertainties are larger and thus the possible electron anisotropies could be larger