59 research outputs found
Caspase-8 regulation of TRAIL-mediated cell death
Research on TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors has advanced tremendously over the past 17 years. Initial observations of TRAIL and TRAIL receptor-mediated tumor cell toxicity led to enthusiasm of exploiting this selective, malignant cell killing for cancer therapy. Further examination revealed aberrant TRAIL signaling in some cancer cells leading to protection from TRAIL-mediated cell death. Mechanisms of TRAIL resistance often involve decreased expression or activity of initiator caspase-8, crucial for complete TRAIL signal transduction. Caspase-8 mutations, epigenetic silencing, decrease in stability, and incomplete activation have been reported. This article reviews the discovery of TRAIL and TRAIL receptors and subsequent studies that reveal how expression and function of caspase-8 are central to TRAIL-mediated cell death. This article is part of a Special Issue entitled “Apoptosis: Four Decades Later”
Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells
Detection and Analysis of Living, Growth-Inhibited Mammalian Cells Following Transfection
Relationship of p21WAF1/CIP1/SDI1 to cell proliferation in primary cultures of adrenocortical cells
Classification of cell death : recommendations of the Nomemclature Committee on Cell Death.
p21WAF1/CIP1 expression in gestational trophoblastic disease: correlation with clinicopathological parameters, and Ki67 and p53 gene expression
Molecular markers in dysplasia of the larynx: expression of cyclin-dependent kinase inhibitors p21, p27 and p53 tumour suppressor gene in predicting cancer risk
Effects of Uwhangchungsimwon on Cell Viability, Proliferation, and Gene Expression of Human Neuronal Cell line IMR32
Helicobacter pylori and Epstein-Barr virus infection and the p53 tumour suppressor pathway in gastric stump cancer compared with carcinoma in the non-operated stomach
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