99 research outputs found
Macromolecular effects on the oxidation of thiols : catalyzed by cobalt (II)phtalocyanine-tetra-sodium sulfonate attached to polyamines and polyammonium salts
Autoxidation of thiols with tetrasodium cobalt(II) phthalocyaninetetrasulfonate, bound to poly(vinylamine). 3. Dependence on molecular weight
L'environnement futur en Europe de l'ést et de l'ouest: Consequences de divers scénarios de développement
This study analyzes eleven European environmental policy "dilemmas" for four alternative socioeconomic development pathways to the year 2030. The dilemmas include problems associated with: water management, soil acidification, forestry wood supply, marginalized land, sea level rise, coastal problems, chemical "time bombs", non-point source toxic materials, transport growth, urbanization, and summer oxidant episodes
Future Environments for Europe: Some Implications of Alternative Development Paths
This study analyzes eleven European environmental policy "dilemmas" for four alternative socioeconomic development pathways to the year 2030. The dilemmas include problems associated with: water management, soil acidification, forestry wood supply, marginalized land, sea level rise, coastal problems, chemical "time bombs", non-point source toxic materials, transport growth, urbanization, and summer oxidant episodes
The promoting role of polycations in the cobalt(ii) phthalocyanine tetrasodium sulfonate catalysed oxidation of thiols
Prognostic Impact of HER2 and ER Status of Circulating Tumor Cells in Metastatic Breast Cancer Patients with a HER2-Negative Primary Tumor
AbstractBACKGROUND: Preclinical and clinical studies have reported that human epidermal growth factor receptor 2 (HER2) overexpression yields resistance to endocrine therapies. Here the prevalence and prognostic impact of HER2-positive circulating tumor cells (CTCs) were investigated retrospectively in metastatic breast cancer (MBC) patients with a HER2-negative primary tumor receiving endocrine therapy. Additionally, the prevalence and prognostic significance of HER2-positive CTCs were explored in a chemotherapy cohort, as well as the prognostic impact of the estrogen receptor (ER) CTC status in both cohorts. METHODS: Included were MBC patients with a HER2-negative primary tumor, with ≥1 detectable CTC, starting a new line of treatment. CTCs were enumerated using the CellSearch system, characterized for HER2 with the CellSearch anti-HER2 phenotyping reagent, and characterized for ER mRNA expression. Primary end point was progression-free rate after 6 months (PFR6months) of endocrine treatment in HER2-positive versus HER2-negative CTC patients. RESULTS: HER2-positive CTCs were present in 29% of all patients. In the endocrine cohort (n=72), the PFR6months was 53% for HER2-positive versus 68% for HER2-negative CTC patients (P=.23). In the chemotherapy cohort (n=82), no prognostic value of HER2-positive CTCs on PFR6months was observed either. Discordances in ER status between the primary tumor and CTCs occurred in 25% of all patients but had no prognostic value in exploratory survival analyses. CONCLUSION: Discordances regarding HER2 status and ER status between CTCs and the primary tumor occurred frequently but had no prognostic impact in our MBC patient cohorts
R-CEOP as first-line treatment for anthracycline-ineligible patients with diffuse large B-cell lymphoma
Disruptions of anaerobic gut bacteria are associated with stroke and post-stroke infection: a prospective case-control study
In recent years, preclinical studies have illustrated the potential role of intestinal bacterial composition in the risk of stroke and post-stroke infections. The results of these studies suggest that bacteria capable of producing volatile metabolites, including trimethylamine-N-oxide (TMAO) and butyrate, play opposing, yet important roles in the cascade of events leading to stroke. However, no large-scale studies have been undertaken to determine the abundance of these bacterial communities in stroke patients and to assess the impact of disrupted compositions of the intestinal microbiota on patient outcomes. In this prospective case-control study, rectal swabs from 349 ischemic and hemorrhagic stroke patients (median age, 71 years; IQR: 67-75) were collected within 24 h of hospital admission. Samples were subjected to 16S rRNA amplicon sequencing and subsequently compared with samples obtained from 51 outpatient age- and sex-matched controls (median age, 72 years; IQR, 62-80) with similar cardiovascular risk profiles but without active signs of stroke. Plasma protein biomarkers were analyzed using a combination of nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Alpha and beta diversity analyses revealed higher disruption of intestinal communities during ischemic and hemorrhagic stroke compared with non-stroke matched control subjects. Additionally, we observed an enrichment of bacteria implicated in TMAO production and a loss of butyrate-producing bacteria. Stroke patients displayed two-fold lower plasma levels of TMAO than controls (median 1.97 vs 4.03 mu M, Wilcoxonp < 0.0001). Finally, lower abundance of butyrate-producing bacteria within 24 h of hospital admission was an independent predictor of enhanced risk of post-stroke infection (odds ratio 0.77,p = 0.005), but not of mortality or functional patient outcome. In conclusion, aberrations in trimethylamine- and butyrate-producing gut bacteria are associated with stroke and stroke-associated infections.Proteomic
Angular momentum exchange during secular migration of two-planet systems
We investigate the secular dynamics of two-planet coplanar systems evolving
under mutual gravitational interactions and dissipative forces. We consider two
mechanisms responsible for the planetary migration: star-planet (or
planet-satellite) tidal interactions and interactions of a planet with a
gaseous disc. We show that each migration mechanism is characterized by a
specific law of orbital angular momentum exchange. Calculating stationary
solutions of the conservative secular problem and taking into account the
orbital angular momentum leakage, we trace the evolutionary routes followed by
the planet pairs during the migration process. This procedure allows us to
recover the dynamical history of two-planet systems and constrain parameters of
the involved physical processes.Comment: 20 pages, 9 figures, accepted for publication in Celestial Mechanics
and Dynamical Astronomy (special issue on Exoplanets
A resonant-term-based model including a nascent disk, precession, and oblateness: application to GJ 876
Investigations of two resonant planets orbiting a star or two resonant
satellites orbiting a planet often rely on a few resonant and secular terms in
order to obtain a representative quantitative description of the system's
dynamical evolution. We present a semianalytic model which traces the orbital
evolution of any two resonant bodies in a first- through fourth-order
eccentricity or inclination-based resonance dominated by the resonant and
secular arguments of the user's choosing. By considering the variation of
libration width with different orbital parameters, we identify regions of phase
space which give rise to different resonant ''depths,'' and propose methods to
model libration profiles. We apply the model to the GJ 876 extrasolar planetary
system, quantify the relative importance of the relevant resonant and secular
contributions, and thereby assess the goodness of the common approximation of
representing the system by just the presumably dominant terms. We highlight the
danger in using ''order'' as the metric for accuracy in the orbital solution by
revealing the unnatural libration centers produced by the second-order, but not
first-order, solution, and by demonstrating that the true orbital solution lies
somewhere ''in-between'' the third- and fourth-order solutions. We also present
formulas used to incorporate perturbations from central-body oblateness and
precession, and a protoplanetary or protosatellite thin disk with gaps, into a
resonant system. We quantify these contributions to the GJ 876 system, and
thereby highlight the conditions which must exist for multi-planet exosystems
to be significantly influenced by such factors. We find that massive enough
disks may convert resonant libration into circulation; such disk-induced
signatures may provide constraints for future studies of exoplanet systems.Comment: 39 pages of body text, 21 figures, 5 tables, 1 appendix, accepted for
publication in Celestial Mechanics and Dynamical Astronom
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