Studentevorming*

By navraag oor wat die aard van 'n inougurele rede moet wees, het ek tussen die uiteenlopende antwoorde gekies vir dié standpunt dat 'n inougurele rede moet poog om 'n perspektief te gee op die leerstoel wat beklee word, op so ’n wyse dat alle kollegas en belangstellendes kan begryp waarom dit gaan

Die klinies pastorale vorming in Nederland en voorstelle vir Suid-Afrika

No abstract available

Die pastoraal-psigologiese benadering van die jeug

No abstract available

Branched-chain amino acid levels are inversely associated with incident and prevalent chronic kidney disease in people with type 2 diabetes

Aim: To investigate the association of plasma metabolites with incident and prevalent chronic kidney disease (CKD) in people with type 2 diabetes and establish whether this association is causal. Materials and Methods: The Hoorn Diabetes Care System cohort is a large prospective cohort consisting of individuals with type 2 diabetes from the northwest part of the Netherlands. In this cohort we assessed the association of baseline plasma levels of 172 metabolites with incident (Ntotal = 462/Ncase = 81) and prevalent (Ntotal = 1247/Ncase = 120) CKD using logistic regression. Additionally, replication in the UK Biobank, body mass index (BMI) mediation and causality of the association with Mendelian randomization was performed. Results: Elevated levels of total and individual branched-chain amino acids (BCAAs)—valine, leucine and isoleucine—were associated with an increased risk of incident CKD, but with reduced odds of prevalent CKD, where BMI was identified as an effect modifier. The observed inverse effects were replicated in the UK Biobank. Mendelian randomization analysis did not provide evidence for a causal relationship between BCAAs and prevalent CKD. Conclusions: Our study shows the intricate relationship between plasma BCAA levels and CKD in individuals with type 2 diabetes. While an association exists, its manifestation varies based on disease status and BMI, with no definitive evidence supporting a causal link between BCAAs and prevalent CKD

Cu/Pd and Cu/Pt of silicate rocks in the Bushveld Complex ; implications for platinum-group element exploration

The Bushveld complex contains the bulk of the world's reserves of PGE. A total of 89 samples were analysed for Cu, Pd and Pt. The stratigraphy, sampling and analytical methods are reviewed and the results are discussed. The data are tabulated, plotted and discussed