53 research outputs found
Time-frequency detection algorithm for gravitational wave bursts
An efficient algorithm is presented for the identification of short bursts of
gravitational radiation in the data from broad-band interferometric detectors.
The algorithm consists of three steps: pixels of the time-frequency
representation of the data that have power above a fixed threshold are first
identified. Clusters of such pixels that conform to a set of rules on their
size and their proximity to other clusters are formed, and a final threshold is
applied on the power integrated over all pixels in such clusters. Formal
arguments are given to support the conjecture that this algorithm is very
efficient for a wide class of signals. A precise model for the false alarm rate
of this algorithm is presented, and it is shown using a number of
representative numerical simulations to be accurate at the 1% level for most
values of the parameters, with maximal error around 10%.Comment: 26 pages, 15 figures, to appear in PR
A multicomponent intervention to decrease sedentary time during hospitalization: a quasi-experimental pilot study
Objective:The aim of this study was to evaluate the feasibility and preliminary effects of a multicomponent intervention to decrease sedentary time during and shortly after hospitalization.Design:This is a quasi-experimental pilot study comparing outcomes in patients admitted before and after the implementation of the intervention.Setting:The study was conducted in a university hospital.Subjects:Participants were adult patients undergoing elective organ transplantation or vascular surgery.Interventions:In the control phase, patients received usual care, whereas in the intervention phase, patients also received a multicomponent intervention to decrease sedentary time. The intervention comprised eight elements: paper and digital information, an exercise movie, an activity planner, a pedometer and Fitbit Flex (TM), a personal activity coach and an individualized digital training program.Measures:Measures of feasiblity were the self-reported use of the intervention components (yes/no) and satisfaction (low-high = 0-10). Main outcome measure was the median % of sedentary time measured by an accelerometer worn during hospitalization and 7-14 days thereafter.Results:A total of 42 controls (mean age = 59 years, 62% male) and 52 intervention patients (58 years, 52%) were included. The exercise movie, paper information and Fitbit Flex were the three most frequently used components, with highest satisfaction scores for the fitbit, paper information, exercise movie and digital training. Median sedentary time decreased from 99.6% to 95.7% and 99.3% to 91.0% between Days 1 and 6 in patients admitted in the control and intervention phases, respectively. The difference at Day 6 reached statistical significance (difference = 41 min/day, P = 0.01). No differences were seen after discharge.Conclusion:Implementing a multicomponent intervention to reduce sedentary time appeared feasible and may be effective during but not directly after hospitalization.Vascular Surger
Evaluation of fecal recovering and long term bias of internal and external markers in a digestion assay with cattle
Study protocol for a multicenter randomized controlled trial to compare the efficacy of end-ischemic dual hypothermic oxygenated machine perfusion with static cold storage in preventing non-anastomotic biliary strictures after transplantation of liver grafts donated after circulatory death: DHOPE-DCD trial
Background: The major concern in liver transplantation of grafts from donation after circulatory death (DCD)
donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been
proposed as an alternative strategy for organ preservation which reduces ischemia-reperfusion injury (IRI).
Experimental studies have shown that dual hypothermic oxygenated machine perfusion (DHOPE) is associated with
less IRI, improved hepatocellular function, and better preserved mitochondrial and endothelial function compared
to conventional static cold storage (SCS). Moreover, DHOPE was safely applied with promising results in a recently
performed phase-1 study. The aim of the current study is to determine the efficacy of DHOPE in reducing the
incidence of NAS after DCD liver transplantation.
Methods: This is an international multicenter randomized controlled trial. Adult patients (≥18 yrs. old) undergoing
transplantation of a DCD donor liver (Maastricht category III) will be randomized between the intervention and
control group. In the intervention group, livers will be subjected to two hours of end-ischemic DHOPE after SCS
and before implantation. In the control group, livers will be subjected to care as usual with conventional SCS only.
Primary outcome is the incidence of symptomatic NAS diagnosed by a blinded adjudication committee. In all
patients, magnetic resonance cholangiography will be obtained at six months after transplantation.
Discussion: DHOPE is associated with reduced IRI of the bile ducts. Whether reduced IRI of the bile ducts leads to
lower incidence of NAS after DCD liver transplantation can only be examined in a randomized controlled trial. Trial registration: The trial was registered in Clinicaltrials.gov in September 2015 with the identifier NCT02584283
Suplemento múltiplo com ionóforos para novilhos em pasto: consumo, fermentação ruminal e degradabilidade in situ
Níveis de proteína em suplementos para terminação de bovinos em pastejo durante o período de transição Seca/Águas: digestibilidade aparente e parâmetros do metabolismo ruminal e dos compostos nitrogenados
Utilização da biomassa remanescente de pastagens de estação fria para produção de forragem conservada
Simulação e validação de parâmetros da cinética digestiva em novilhos mestiços suplementados a pasto, por intermédio do sistema in vitro de produção de gases
Fecal excretion patterns and short term bias of internal and external markers in a digestion assay with cattle
Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature
Truncating variants in exons 33 and 34 of the SNF2-related CREBBP activator protein (SRCAP) gene cause the neurodevelopmental disorder (NDD) Floating-Harbor syndrome (FLHS), characterized by short stature, speech delay, and facial dysmorphism. Here, we present a cohort of 33 individuals with clinical features distinct from FLHS and truncating (mostly de novo) SRCAP variants either proximal (n = 28) or distal (n = 5) to the FLHS locus. Detailed clinical characterization of the proximal SRCAP individuals identified shared characteristics: developmental delay with or without intellectual disability, behavioral and psychiatric problems, non-specific facial features, musculoskeletal issues, and hypotonia. Because FLHS is known to be associated with a unique set of DNA methylation (DNAm) changes in blood, a DNAm signature, we investigated whether there was a distinct signature associated with our affected individuals. A machine-learning model, based on the FLHS DNAm signature, negatively classified all our tested subjects. Comparing proximal variants with typically developing controls, we identified a DNAm signature distinct from the FLHS signature. Based on the DNAm and clinical data, we refer to the condition as "non-FLHS SRCAP-related NDD.'' All five distal variants classified negatively using the FLHS DNAm model while two classified positively using the proximal model. This suggests divergent pathogenicity of these variants, though clinically the distal group presented with NDD, similar to the proximal SRCAP group. In summary, for SRCAP, there is a clear relationship between variant location, DNAm profile, and clinical phenotype. These results highlight the power of combined epigenetic, molecular, and clinical studies to identify and characterize genotype-epigenotype-phenotype correlations.Genetics of disease, diagnosis and treatmen
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