Role of arginase 2 in systemic metabolic activity and adipose tissue fatty acid metabolism in diet-induced obese mice

Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase enzyme with two isoforms (A1-cytosolic and A2-mitochondrial), is implicated in pathologies associated with obesity and diabetes. This study examined A2 involvement in obesity-associated metabolic and vascular disorders. WT and globally deleted A2(−/−) or A1(+/−) mice were fed either a high fat/high sucrose (HFHS) diet or normal diet (ND) for 16 weeks. Increases in body and VAT weight of HFHS-fed WT mice were abrogated in A2−/−, but not A1+/−, mice. Additionally, A2−/− HFHS-fed mice exhibited higher energy expenditure, lower blood glucose, and insulin levels compared to WT HFHS mice. VAT and adipocytes from WT HFHS fed mice showed greater A2 expression and adipocyte size and reduced expression of PGC-1α, PPAR-γ, and adiponectin. A2 deletion blunted these effects, increased levels of active AMPK-α, and upregulated genes involved in fatty acid metabolism. A2 deletion prevented HFHS-induced VAT collagen deposition and inflammation, which are involved in adipocyte metabolic dysfunction. Endothelium-dependent vasorelaxation, impaired by HFHS diet, was significantly preserved in A2−/− mice, but more prominently maintained in A1+/− mice. In summary, A2 is critically involved in HFHS-induced VAT inflammation and metabolic dysfunction

Collapse of a Circular Loop of Cosmic String

We study the collapse of a circular loop of cosmic string. The gravitational field of the string is treated using the weak field approximation. The gravitational radiation from the loop is evaluated numerically. The memtric of the loop near the point of collapse is found analytically.Comment: 15 page

Stringent constraint on the scalar-neutrino coupling constant from quintessential cosmology

An extremely light ($m_{\phi} \ll 10^{-33} {\rm eV}$), slowly-varying scalar field $\phi$ (quintessence) with a potential energy density as large as 60% of the critical density has been proposed as the origin of the accelerated expansion of the Universe at present. The interaction of this smoothly distributed component with another predominately smooth component, the cosmic neutrino background, is studied. The slow-roll approximation for generic $\phi$ potentials may then be used to obtain a limit on the scalar-neutrino coupling constant, found to be many orders of magnitude more stringent than the limits set by observations of neutrinos from SN 1987A. In addition, if quintessential theory allows for a violation of the equivalence principle in the sector of neutrinos, the current solar neutrino data can probe such a violation at the 10^{-10} level.Comment: 7 pages, MPLA in press, some parts disregarded and a footnote adde

Historic Scour Data Collected at Selected Bridges in South Carolina

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

Gravitational wave bursts from cusps and kinks on cosmic strings

The strong beams of high-frequency gravitational waves (GW) emitted by cusps and kinks of cosmic strings are studied in detail. As a consequence of these beams, the stochastic ensemble of GW's generated by a cosmological network of oscillating loops is strongly non Gaussian, and includes occasional sharp bursts that stand above the ``confusion'' GW noise made of many smaller overlapping bursts. Even if only 10% of all string loops have cusps these bursts might be detectable by the planned GW detectors LIGO/VIRGO and LISA for string tensions as small as $G \mu \sim 10^{-13}$. In the implausible case where the average cusp number per loop oscillation is extremely small, the smaller bursts emitted by the ubiquitous kinks will be detectable by LISA for string tensions as small as $G \mu \sim 10^{-12}$. We show that the strongly non Gaussian nature of the stochastic GW's generated by strings modifies the usual derivation of constraints on $G \mu$ from pulsar timing experiments. In particular the usually considered ``rms GW background'' is, when G \mu \gaq 10^{-7}, an overestimate of the more relevant confusion GW noise because it includes rare, intense bursts. The consideration of the confusion GW noise suggests that a Grand Unified Theory (GUT) value $G \mu \sim 10^{-6}$ is compatible with existing pulsar data, and that a modest improvement in pulsar timing accuracy could detect the confusion noise coming from a network of cuspy string loops down to $G \mu \sim 10^{-11}$. The GW bursts discussed here might be accompanied by Gamma Ray Bursts.Comment: 24 pages, 3 figures, Revtex, submitted to Phys. Rev.

Analytic Results for the Gravitational Radiation from a Class of Cosmic String Loops

Cosmic string loops are defined by a pair of periodic functions ${\bf a}$ and ${\bf b}$, which trace out unit-length closed curves in three-dimensional space. We consider a particular class of loops, for which ${\bf a}$ lies along a line and ${\bf b}$ lies in the plane orthogonal to that line. For this class of cosmic string loops one may give a simple analytic expression for the power $\gamma$ radiated in gravitational waves. We evaluate $\gamma$ exactly in closed form for several special cases: (1) ${\bf b}$ a circle traversed $M$ times; (2) ${\bf b}$ a regular polygon with $N$ sides and interior vertex angle $\pi-2\pi M/N$; (3) ${\bf b}$ an isosceles triangle with semi-angle $\theta$. We prove that case (1) with $M=1$ is the absolute minimum of $\gamma$ within our special class of loops, and identify all the stationary points of $\gamma$ in this class.Comment: 15 pages, RevTex 3.0, 7 figures available via anonymous ftp from directory pub/pcasper at alpha1.csd.uwm.edu, WISC-MILW-94-TH-1

Fine structure and optical properties of biological polarizers in crustaceans and cephalopods

The lighting of the underwater environment is constantly changing due to attenuation by water, scattering by suspended particles, as well as the refraction and reflection caused by the surface waves. These factors pose a great challenge for marine animals which communicate through visual signals, especially those based on color. To escape this problem, certain cephalopod mollusks and stomatopod crustaceans utilize the polarization properties of light. While the mechanisms behind the polarization vision of these two animal groups are similar, several distinctive types of polarizers (i.e. the structure producing the signal) have been found in these animals. To gain a better knowledge of how these polarizers function, we studied the relationships between fine structures and optical properties of four types of polarizers found in cephalopods and stomatopods. Although all the polarizers share a somewhat similar spectral range, around 450- 550 nm, the reflectance properties of the signals and the mechanisms used to produce them have dramatic differences. In cephalopods, stack-plates polarizers produce the polarization patterns found on the arms and around their eyes. In stomatopods, we have found one type of beam-splitting polarizer based on photonic structures and two absorptive polarizer types based on dichroic molecules. These stomatopod polarizers may be found on various appendages, and on the cuticle covering dorsal or lateral sides of the animal. Since the efficiencies of all these polarizer types are somewhat sensitive to the change of illumination and viewing angle, how these animals compensate with different behaviors or fine structural features of the polarizer also varies

Mid-Infrared Emission from E+A Galaxies in the Coma Cluster

We have used ISO to observe at 12$\mu$m seven E+A galaxies plus an additional emission line galaxy, all in the Coma cluster. E+A galaxies lacking narrow emission lines have 2.2$\mu$m to 12$\mu$m flux density ratios or limits similar to old stellar populations (typical of early-type galaxies). Only galaxies with emission lines have enhanced 12$\mu$m flux density. Excess 12$\mu$m emission is therefore correlated with the presence of on-going star formation or an active galactic nucleus (AGN). By comparing the current star formation rates with previous rates estimated from the Balmer absorption features, we divide the galaxies into two groups: those for which star formation has declined significantly following a dramatic peak $\sim$ 1 Gyr ago; and those with a significant level of ongoing star formation or/and an AGN. There is no strong difference in the spatial distribution on the sky between these two groups. However, the first group has systemic velocities above the mean cluster value and the second group below that value. This suggests that the two groups differ kinematically. Based on surveys of the Coma cluster in the radio, the IRAS sources, and galaxies detected in H$\alpha$ emission, we sum the far infrared luminosity function of galaxies in the cluster. We find that star formation in late type galaxies is probably the dominant component of the Coma cluster far infrared luminosity. The presence of significant emission from intracluster dust is not yet firmly established. The member galaxies also account for most of the far infrared output from nearby rich clusters in general.Comment: AAS Latex, accepted for publication in Ap