Art Versus Life in German Literature

Public lecture delivered at the Rice Institute on November 22, 195

Trading Water: Using Tradable Permits to Promote Conservation and Efficient Allocation of an Increasingly Scarce Resource

This Comment argues that a free-market system for water-use rights should be implemented to address and prevent water shortages. A water market system would require that secure property rights be attached to water use and that those rights be freely tradable. Current water-rights regimes used in the United States are not sufficient to support such a market system because current regimes do not grant secure property rights in water use, and it is unclear to what extent water-use rights can be transferred. Therefore, a market system under the current water-rights regimes would not be able to maximize its potential to promote efficient allocation of water resources

Sandra Parks and Lamar Puckett in a Joint Senior Recital

This is the program for the joint senior recital of pianist Sandra W. Parks and baritone Lamar Puckett. Flutist Jane Chu assisted Parks; pianist Cynthia McDonnough assisted Puckett. The recital took place on February 14, 1978, in the Mabee Fine Arts Center Recital Hall

Identification of DVA Interneuron Regulatory Sequences in Caenorhabditis elegans

Background: The identity of each neuron is determined by the expression of a distinct group of genes comprising its terminal gene battery. The regulatory sequences that control the expression of such terminal gene batteries in individual neurons is largely unknown. The existence of a complete genome sequence for C. elegans and draft genomes of other nematodes let us use comparative genomics to identify regulatory sequences directing expression in the DVA interneuron. Methodology/Principal Findings: Using phylogenetic comparisons of multiple Caenorhabditis species, we identified conserved non-coding sequences in 3 of 10 genes (fax-1, nmr-1, and twk-16) that direct expression of reporter transgenes in DVA and other neurons. The conserved region and flanking sequences in an 85-bp intronic region of the twk-16 gene directs highly restricted expression in DVA. Mutagenesis of this 85 bp region shows that it has at least four regions. The central 53 bp region contains a 29 bp region that represses expression and a 24 bp region that drives broad neuronal expression. Two short flanking regions restrict expression of the twk-16 gene to DVA. A shared GA-rich motif was identified in three of these genes but had opposite effects on expression when mutated in the nmr-1 and twk-16 DVA regulatory elements. Conclusions/Significance: We identified by multi-species conservation regulatory regions within three genes that direct expression in the DVA neuron. We identified four contiguous regions of sequence of the twk-16 gene enhancer with positive and negative effects on expression, which combined to restrict expression to the DVA neuron. For this neuron a single binding site may thus not achieve sufficient specificity for cell specific expression. One of the positive elements, an 8-bp sequence required for expression was identified in silico by sequence comparisons of seven nematode species, demonstrating the potential resolution of expanded multi-species phylogenetic comparisons

A C-14 labeled Py–Im polyamide localizes to a subcutaneous prostate cancer tumor

AbstractIn an effort to quantitate Py–Im polyamide concentrations in vivo, we synthesized the C-14 radioactively labeled compounds 1–3, and investigated their tumor localization in a subcutaneous xenograft model of prostate cancer (LNCaP). Tumor concentrations were compared with representative host tissues, and exhibited a certain degree of preferential localization to the xenograft. Compound accumulation upon repeated administration was measured. Py–Im polyamide 1 was found to accumulate in LNCaP tumors at concentrations similar to the IC50 value for this compound in cell culture experiments

Indenture, Marshall County, MS, 13 November 1855

https://egrove.olemiss.edu/aldrichcorr_c/1107/thumbnail.jp