42 research outputs found
Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype
Get PDFAbstract The aim of the present study was to establish mitochondrial cholesterol trafficking 18 kDa translocator protein (TSPO) as a potential therapeutic target, capable of increasing macrophage cholesterol efflux to (apo)lipoprotein acceptors. Expression and activity of TSPO in human (THP-1) macrophages were manipulated genetically and by the use of selective TSPO ligands
REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis
Get PDFThe nuclear receptor REV-ERBα shapes the daily activity profile of Sterol Response Element Binding Protein (SREBP) and thereby participates in the circadian control of cholesterol and bile acid synthesis in the liver
Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis
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Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver
No full textRegulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25-Hydroxycholesterol and 25-Hydroxycholesterol-3-sulfate
No full textMitochondrial Cholesterol Transporter, StAR, Inhibits Human THP-1 Monocyte-Derived Macrophage Apoptosis
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