Astrometry.net: Blind astrometric calibration of arbitrary astronomical images

We have built a reliable and robust system that takes as input an astronomical image, and returns as output the pointing, scale, and orientation of that image (the astrometric calibration or WCS information). The system requires no first guess, and works with the information in the image pixels alone; that is, the problem is a generalization of the "lost in space" problem in which nothing--not even the image scale--is known. After robust source detection is performed in the input image, asterisms (sets of four or five stars) are geometrically hashed and compared to pre-indexed hashes to generate hypotheses about the astrometric calibration. A hypothesis is only accepted as true if it passes a Bayesian decision theory test against a background hypothesis. With indices built from the USNO-B Catalog and designed for uniformity of coverage and redundancy, the success rate is 99.9% for contemporary near-ultraviolet and visual imaging survey data, with no false positives. The failure rate is consistent with the incompleteness of the USNO-B Catalog; augmentation with indices built from the 2MASS Catalog brings the completeness to 100% with no false positives. We are using this system to generate consistent and standards-compliant meta-data for digital and digitized imaging from plate repositories, automated observatories, individual scientific investigators, and hobbyists. This is the first step in a program of making it possible to trust calibration meta-data for astronomical data of arbitrary provenance.Comment: submitted to A

A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis.

ObjectiveEtrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7, which are implicated in leucocyte migration and retention in ulcerative colitis (UC). This randomised phase I study evaluated the safety and pharmacology of etrolizumab in patients with moderate to severe UC.DesignIn the single ascending dose (SAD) stage, etrolizumab (0.3, 1.0, 3.0, 10 mg/kg intravenous, 3.0 mg/kg subcutaneous (SC) or placebo) was administered 4:1 (n=25) in each cohort. In the multiple dose (MD) stage, new patients received monthly etrolizumab (0.5 mg/kg SC (n=4), 1.5 mg/kg SC (n=5), 3.0 mg/kg SC (n=4), 4.0 mg/kg intravenous (n=5)) or placebo (n=5). The pharmacokinetics was studied and Mayo Clinic Score evaluated at baseline, day 29 (SAD), and days 43 and 71 (MD).ResultsIn the SAD stage, there were no dose limiting toxicities, infusion or injection site reactions. Two impaired wound healing serious adverse events occurred in two patients receiving etrolizumab. In the MD stage, there were no dose limiting toxicities, and no infusion or injection site reactions. Headache was the most common adverse event, occurring more often in etrolizumab patients. Antietrolizumab antibodies were detected in two subjects. The duration of β7 receptor full occupancy was dose related. A clinical response was observed in 12/18 patients, and clinical remission in 3/18 patients treated with etrolizumab in the MD stage, compared with 4/5 and 1/5 placebo patients, respectively.ConclusionEtrolizumab is well tolerated in moderate to severe UC. Further investigation is warranted

Seismicity of the central Afar rift and implications for Tendaho dam hazards

Temporary broadband seismic networks deployed from 2007 to 2011 around the Afar triple junction of the East African Rift System provide insights into seismicity patterns of the actively deforming crust around the 1.86 km3 impounded lake system behind the Tendaho dam. The observed seismicity correlates well with the active magmatic centres around central Afar. The area around the dam site is characterized by a network of intersecting NNE- and NW-trending faults. Seismicity clusters observed in the specified time interval indicate that both fault sets are active and are potential sources of seismogenic hazards. The dam neighbourhood is naturally active and it is a challenge to associate the observed seismic activity to either a change in magmato-tectonic conditions or attribute it to the influence of reservoir load. It is evident that the dam region experi- ences high levels of seismic and volcano-tectonic unrest, regardless of the origin of the activity. The spatial overlap of narrow zones of crustal seismicity and upper mantle low velocity zones observed in S-wave tomography models suggests that melt production zones guide the distribution of strain during continental rupture. Given its volcanically and seismically active setting, the Tendaho dam site and the surrounding region require continuous monitoring for the safety of downstream popu- lations and development infrastructures in the Afar National Regional State of Ethiopia

Differentiating flow, melt, or fossil seismic anisotropy beneath Ethiopia

Ethiopia is a region where continental rifting gives way to oceanic spreading. Yet the role that pre-existing lithospheric structure, melt, mantle flow, or active upwellings may play in this process is debated. Measurements of seismic anisotropy are often used to attempt to understand the contribution that these mechanisms may play. In this study, we use new data in Afar, Ethiopia along with legacy data across Ethiopia, Djibouti, and Yemen to obtain estimates of mantle anisotropy using SKS-wave splitting. We show that two layers of anisotropy exist, and we directly invert for these. We show that fossil anisotropy with fast directions oriented northeast-southwest may be preserved in the lithosphere away from the rift. Beneath the Main Ethiopian Rift and parts of Afar, anisotropy due to shear segregated melt along sharp changes in lithospheric thickness dominates the shear-wave splitting signal in the mantle. Beneath Afar, away from regions with significant lithospheric topography, melt pockets associated with the crustal and uppermost mantle magma storage dominate the signal in localized regions. In general, little anisotropy is seen in the uppermost mantle beneath Afar suggesting melt retains no preferential alignment. These results show the important role melt plays in weakening the lithosphere and imply that as rifting evolves passive upwelling sustains extension. A dominant northeast-southwest anisotropic fast direction is observed in a deeper layer across all of Ethiopia. This suggests that a conduit like plume is lacking beneath Afar today, rather a broad flow from the southwest dominates flow in the upper mantle

Inhibition of Defocus-Induced Myopia in Chickens

Woods, J., Guthrie, S. E., Keir, N., Dillehay, S., Tyson, M., Griffin, R., … Irving, E. (2013). Inhibition of Defocus-Induced Myopia in Chickens. Investigative Opthalmology & Visual Science, 54(4), 2662. https://doi.org/10.1167/iovs.12-10742Purpose.: To determine the effect of wearing a lens with a unique peripheral optical design on the development and progression of defocus-induced myopia in newly hatched chickens.Methods.: Eighty-five newly hatched chickens underwent bilateral retinoscopy and A-scan ultrasound to determine their refractive error and axial length. They were randomly divided into Control and two Test groups, in which each chicken was fitted with a goggle-lens over the right eye, with the left eye remaining untreated. The Control group wore a lens of power −10.00 diopters (D) of standard spherical optical design. The two Test lenses both had a central optical power −10.00 D, but used different peripheral myopia progression control (MPC) designs. For all groups, retinoscopy was repeated on days 3, 7, 10, and 14; ultrasound was repeated on day 14. Results.: On day 0 there was no statistical difference in refractive error (mean +6.92 D) or axial length (mean 8.06 mm) between Test and Control groups or treated and untreated eyes (all P > 0.05). At day 14, 37 (43.5%) of 85 chickens had not experienced goggle detachment and were included in the final analyses. In this cohort there was a significant refractive difference between the treated eyes of the Control group (n = 17) and those of Test 1 (n = 14) and Test 2 (n = 6) groups (both P < 0.01): Control −4.65 ± 2.11 D, Test 1 +4.57 ± 3.11 D, Test 2 +1.08 ± 1.24 D (mean ± SEM). There was also a significant axial length difference (both P < 0.01): Control 10.55 ± 0.36 mm, Test 1 9.99 ± 0.14 mm, Test 2 10.17 ± 0.18 mm. Conclusions.: Use of these unique MPC lens designs over 14 days caused a significant reduction in the development of defocus-induced myopia in chickens; the degree of reduction appeared to be design specific