Clinical Outcome of Intra-Arterial Embolization for Treatment of Patients with Pelvic Trauma

Purpose. To analyse the technical success of pelvic embolization in our institution and to assess periprocedural hemodynamic status and morbidity/mortality of all pelvic trauma patients who underwent pelvic embolization. Methods. A retrospective analysis of patients with a pelvic fracture due to trauma who underwent arterial embolization was performed. Clinical data, pelvic radiographs, contrast-enhanced CT-scans, and angiographic findings were reviewed. Subsequently, the technical success and peri-procedural hemodynamic status were evaluated and described. Results. 19 trauma patients with fractures of the pelvis underwent arterial embolization. Initially, 10/19 patients (53%) were hemodynamically unstable prior to embolization. Technical success of embolization was 100%. 14/19 patients (74%) were stable after embolization, and treatment success was high as 74%. Conclusion. Angiography with subsequent embolization should be performed in patients with a pelvic fracture due to trauma and hemodynamic instability, after surgical intervention or with a persistent arterial blush indicative of an active bleeding on CT

Особенности деонтологии в сексологической практике

Описаны основные принципы врачебной этики в сексологической практике. Рассмотрены особенности взаимоотношений врача−сексолога и пациента. Подчеркивается, что выполнение врачом деонтологических принципов будет способствовать гармонизации семейно−сексуальных отношений.Basic principles of medical ethics in sexological practice are presented. The peculiarities of mutual relations of the doctor sexologist and the patient are discussed. It is emphasized that adherence of the doctor−sexologist of ethical principles will promote harmonization of family sexual relations

Semi-Analytical Models for the Formation of Disk Galaxies II. Dark Matter versus Modified Newtonian Dynamics

We present detailed semi-analytical models for the formation of disk galaxies both in a Universe dominated by dark matter (DM), and in one for which the force law is given by modified Newtonian dynamics (MOND). We tune the models to fit the observed near-infrared Tully-Fisher (TF) relation, and compare numerous predictions of the resulting models with observations. The DM and MOND models are almost indistinguishable. They both yield gas mass fractions and dynamical mass-to-light ratios which are in good agreement with observations. Both models reproduce the narrow relation between global mass-to-light ratio and central surface brightness, and reveal a characteristic acceleration, contrary to claims that these relations are not predicted by DM models. Both models require SN feedback in order to reproduce the lack of high surface brightness dwarf galaxies. However, the introduction of feedback to the MOND models steepens the TF relation and increases the scatter, making MOND only marginally consistent with observations. The most serious problem for the DM models is their prediction of steep central rotation curves. However, the DM rotation curves are only slightly steeper than those of MOND, and are only marginally inconsistent with the poor resolution data on LSB galaxies.Comment: 26 pages, 11 figures. Accepted for publication in Ap

Quality of life and toxicity guided treatment plan optimisation for head and neck cancer

PURPOSE: To evaluate the feasibility of semi-automatic Quality of Life (QOL)-weighted normal tissue complication probability (NTCP)-guided VMAT treatment plan optimisation in head and neck cancer (HNC) and compare predicted QOL to that obtained with conventional treatment. MATERIALS AND METHODS: This study included 30 HNC patients who were treated with definitive radiotherapy. QOL-weighted NTCP-guided VMAT plans were optimised directly on 80 multivariable NTCP models of 20 common toxicities and symptoms on 4 different time points (6, 12, 18 and 24 months after radiotherapy) and each NTCP model was weighted relative to its impact on QOL. Planning results, NTCP and predicted QOL were compared with the clinical conventional VMAT plans. RESULTS: QOL-weighted NTCP-guided VMAT plans were clinically acceptable, had target coverage equally adequate as the clinical plans, but prioritised sparing of organs at risk (OAR) related to toxicities and symptoms that had the highest impact on QOL. NTCP was reduced for, e.g., dysphagia (-6.1% for ≥ grade 2/ -7.6% for ≥ grade 3) and moderate-to-severe fatigue / speech problems / hoarseness (-0.7%/ -1.5%/ -2.5%) at 6 months, respectively. Concurrently, the average NTCP of toxicities related to salivary function increased with +0.4% to +5.7%. QOL-weighted NTCP-guided plans were produced in less time, were less dependent on the treatment planner experience and yielded more consistent results. The average predicted QOL improved by 0.7, 0.9, 1.0, and 1.1 points on a 0-100 scale (p < 0.001) at 6, 12, 18, and 24 months, respectively, compared to the clinical plans. CONCLUSION: Semi-automatic QOL-weighted NTCP-guided VMAT treatment plan optimisation is feasible. It prioritised sparing of OARs related to high-impact toxicities and symptoms and resulted in a systematic improvement of predicted QOL compared to conventional VMAT

Dusty Nuclear Disks and Filaments in Early Type Galaxies

We examine the dust properties of a nearby distance-limited sample of early type galaxies using the WFPC2 of the Hubble Space Telescope. Dust is detected in 29 out of 67 galaxies (43%), including 12 with small nuclear dusty disks. In a separate sample of 40 galaxies biased for the detection of dust by virtue of their detection in the IRAS 100 micron band, dust is found in ~78% of the galaxies, 15 of which contain dusty disks. In those galaxies with detectable dust, the apparent mass of the dust correlates with radio and far infrared luminosity, becoming more significant for systems with filamentary dust. A majority of IRAS and radio detections are also associated with dusty galaxies rather than dustless galaxies. This indicates that thermal emission from clumpy, filamentary dust is the main source of the far-IR radiation in early type galaxies. Dust in small disk-like morphology tends to be well aligned with the major axis of the host galaxies, while filamentary dust appears to be more randomly distributed with no preference for alignment with any major galactic structure. This suggests that, if the dusty disks and filaments have a common origin, the dust originates externally and requires time to dynamically relax and settle in the galaxy potential in the form of compact disks. More galaxies with visible dust than without dust display emission lines, indicative of ionized gas, although such nuclear activity does not show a preference for dusty disk over filamentary dust. There appears to be a weak relationship between the mass of the dusty disks and central velocity dispersion of the galaxy, suggesting a connection with a similar recently recognized relationship between the latter and the black hole mass.Comment: 17 pages, including 10 figures & 7 tables, to be published in the Astronomical Journa

Гибридная интегральная схема для обработки звукового сигнала

Разработана гибридная интегральная схема с номинальным напряжением питания 1,4 В, током потребления 0,7 мА и габаритными размерами 8x4x3 мм для обработки звукового сигнала в автономной аппаратуре.Розроблена гібридна інтегральна схема з номінальною напругою живлення 1,4 В, струмом споживання 0,7 мА і габаритними розмірами 8x4x3 мм забезпечує багатофункціональну обробку звуковою сигналу в аналоговій мікроелектронній апаратурі. Наведено її конструкторсько-технологічні та електричні параметри.Developed hybrid integrated circuit with rated supply voltage of 1,4 V, current consumption 0,7 mA and overall dimensions 8x4x3 mm provides soft processing of the audio signal in analog microelectronic equipment. Given its design, technological and electrical parameters