Archaea produce lower yields of N2O than bacteria during aerobic ammonia oxidation in soil

Acknowledgments The authors are members of the Nitrous Oxide Research Alliance (NORA), a Marie Skłodowska-Curie ITN and research project under the EU's seventh framework program (FP7). GN is funded by the AXA Research Fund. The authors would like to thank Dr Nicholas Morley for assistance with gas chromatography, Dr Robin Walker and the SRUC Craibstone Estate (Aberdeen) for access to the agricultural plots and Dr Thomas Cornulier for statistical advice.Peer reviewedPublisher PD

Nitrous oxide production by ammonia oxidizers : Physiological diversity, niche differentiation and potential mitigation strategies

Funding Information: This work was financially supported by the AXA Research Fund (GWN), a Royal Society University Research Fellowship UF150571 (CGR) and all authors are members of the Nitrous Oxide Research Alliance (NORA), a Marie Skłodowska‐Curie ITN and research project under the EU's seventh framework programme (FP7).Peer reviewedPostprin

Genome Sequence of “Candidatus Nitrosocosmicus franklandus” C13, a Terrestrial Ammonia-Oxidizing Archaeon

“Candidatus Nitrosocosmicus franklandus” C13 is an ammonia-oxidizing archaeon (AOA) isolated from soil. Its complete genome is 2.84 Mb and possesses predicted AOA metabolic pathways for energy generation and carbon dioxide fixation but no typical surface layer (S-layer) proteins, only one ammonium transporter, and divergent A-type ATP synthase genes

Co/Ni element ratio in the galactic cosmic rays between 0.8 and 4.3 GeV/nucleon

In a one-day balloon flight of the Trans-Iron Galactic Element Recorder (TIGER) in 1997, the instrument achieved excellent charge resolution for elements near the Fe peak, permitting a new measurement of the element ratio Co/Ni. The best fit to the data, extrapolated to the top of the atmosphere, gives an upper limit for this ratio of 0.093±0.037 over the energy interval 0.8 to 4.3 GeV/nucleon; because a Co peak is not seen in the data, this result is given as an upper limit. Comparing this upper limit with calculations by Webber & Gupta suggests that at the source of these cosmic rays a substantial amount of the electron-capture isotope 59Ni survived. This conclusion is in conflict with the clear evidence from ACE/CRIS below 0.5 GeV/nucleon that there is negligible 59Ni surviving at the source. Possible explanations for this apparent discrepancy are discussed

The Phosphorus/Sulfur Abundance Ratio as a Test of Galactic Cosmic-Ray Source Models

Galactic cosmic-ray (GCR) elemental abundances display a fractionation compared to solar-system values that appears ordered by atomic properties such as the first ionization potential (FIP) or condensation temperature (volatility). Determining which parameter controls the observed fractionation is crucial to distinguish between GCR origin models. The Cosmic-Ray Isotope Spectrometer (CRIS) instrument on board NASA's Advanced Composition Explorer (ACE) spacecraft can measure the abundances of several elements that break the general correlation between FIP and volatility (e.g., Na, P, K, Cu, Zn, Ga, and Ge). Phosphorus is a particularly interesting case as it is a refractory (high condensation temperature) element with a FIP value nearly identical to that of its semi-volatile neighbor, sulfur. Using a leaky-box galactic propagation model we find that the P/S and Na/Mg ratios in the GCR source favor volatility as the controlling parameter

On the Low Energy Decrease in Galactic Cosmic Ray Secondary/Primary Ratios

Galactic cosmic ray (GCR) secondary/primary ratios such as B/C and (Sc+Ti+V)/Fe are commonly used to determine the mean amount of interstellar material through which cosmic rays travel before escaping from the Galaxy (Λ_(esc)). These ratios are observed to be energy-dependent, with a relative maximum at ~1 GeV/nucleon, implying a corresponding peak in Λ_(esc). The decrease in Λ_(esc) at energies above 1 GeV/nucleon is commonly taken to indicate that higher energy cosmic rays escape more easily from the Galaxy. The decrease in Λ_(esc) at energies <1 GeV/nuc is more controversial; suggested possibilities include the effects of a galactic wind or the effects of distributed acceleration of cosmic rays as they pass through the interstellar medium. We consider two possible explanations for the low energy decrease in Λ_(esc) and attempt to fit the combined, high-resolution measurements of secondary/primary ratios from ~0.1 to 35 GeV/nuc made with the CRIS instrument on ACE and the C2 experiment on HEAO-3. The first possibility, which hypothesizes an additional, local component of low-energy cosmic rays that has passed through very little material, is found to have difficulty simultaneously accounting for the abundance of both B and the Fe-secondaries. The second possibility, suggested by Soutoul and Ptuskin, involves a new form for Λ_(esc) motivated by their diffusion-convection model of cosmic rays in the Galaxy. Their suggested form for Λ_(esc)(E) is found to provide an excellent fit to the combined ACE and HEAO data sets

Constraints on cosmic-ray acceleration and transport from isotope observations

Observations from the Cosmic Ray Isotope Spectrometer (CRIS) on ACE have been used to derive constraints on the locations, physical conditions, and time scales for cosmic-ray acceleration and transport. The isotopic composition of Fe, Co, and Ni is very similar to that of solar system material, indicating that cosmic rays contain contributions from supernovae of both Type II and Type Ia. The electron-capture primary ^(59)Ni produced in supernovae has decayed, demonstrating that a time ≳10^5 yr elapses before acceleration of the bulk of the cosmic rays and showing that most of the accelerated material is derived from old stellar or interstellar material rather than from fresh supernova ejecta

Constraints on the nucleosynthesis of refractory nuclides in galactic cosmic rays

Abundances of the isotopes of the refractory elements Ca, Fe, Co, and Ni in the galactic cosmic-ray source are compared with corresponding abundances in solar-system matter. For the 12 nuclides considered, relative abundances agree to within a factor of 2, and typically within 20–30%. In addition, comparisons of cosmic-ray abundances with model calculations of supernova yields are used to argue that cosmic rays contain contributions from stars with a broad range of masses. Based on these and other results we suggest that cosmic rays probably represent a sample of contemporary interstellar matter, at least for refractory species

FiberGLAST: a scintillating fiber approach to the GLAST mission

FiberGLAST is a scintillating fiber gamma-ray detector designed for the GLAST mission. The system described below provides superior effective area and field of view for modest cost and risk. An overview of the FiberGLAST instrument is presented, as well as a more detailed description of the principle elements of the primary detector volume. The triggering and readout electronics are described, and Monte Carlo Simulations of the instrument performance are presented

Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy

Genetic variation may mediate the increased risk of cardiovascular disease (CVD) in chemotherapy-treated testicular cancer (TC) patients compared to the general population. Involved single nucleotide polymorphisms (SNPs) might differ from known CVD-associated SNPs in the general population. We performed an explorative genome-wide association study (GWAS) in TC patients. TC patients treated with platinum-based chemotherapy between 1977 and 2011, age ≤55 years at diagnosis, and ≥3 years relapse-free follow-up were genotyped. Association between SNPs and CVD occurrence during treatment or follow-up was analyzed. Data-driven Expression Prioritized Integration for Complex Trait (DEPICT) provided insight into enriched gene sets, i.e., biological themes. During a median follow-up of 11 years (range 3-37), CVD occurred in 53 (14%) of 375 genotyped patients. Based on 179 SNPs associated at p ≤ 0.001, 141 independent genomic loci associated with CVD occurrence. Subsequent, DEPICT found ten biological themes, with the RAC2/RAC3 network (linked to endothelial activation) as the most prominent theme. Biology of this network was illustrated in a TC cohort (n = 60) by increased circulating endothelial cells during chemotherapy. In conclusion, the ten observed biological themes highlight possible pathways involved in CVD in chemotherapy-treated TC patients. Insight in the genetic susceptibility to CVD in TC patients can aid future intervention strategies