Adverse drug reactions in hospitalized children in Germany are decreasing: results of a nine year cohort-based comparison

published_or_final_versio

Personal preferences for Personalised Trials among patients with chronic diseases: an empirical Bayesian analysis of a conjoint survey.

OBJECTIVE: To describe individual patient preferences for Personalised Trials and to identify factors and conditions associated with patient preferences. DESIGN: Each participant was presented with 18 conjoint questions via an online survey. Each question provided two choices of Personalised Trials that were defined by up to eight attributes, including treatment types, clinician involvement, study logistics and trial burden on a patient. SETTING: Online survey of adults with at least two common chronic conditions in the USA. PARTICIPANTS: A nationally representative sample of 501 individuals were recruited from the Chronic Illness Panel by Harris Poll Online. Participants were recruited from several sources, including emails, social media and telephone recruitment of the target population. MAIN OUTCOME MEASURES: The choice of Personalised Trial design that the participant preferred with each conjoint question. RESULTS: There was large variability in participants\u27 preferences for the design of Personalised Trials. On average, they preferred certain attributes, such as a short time commitment and no cost. Notably, a population-level analysis correctly predicted 62% of the conjoint responses. An empirical Bayesian analysis of the conjoint data, which supported the estimation of individual-level preferences, improved the accuracy to 86%. Based on estimates of individual-level preferences, patients with chronic pain preferred a long study duration (p≤0.001). Asthma patients were less averse to participation burden in terms of data-collection frequency than patients with other conditions (p=0.002). Patients with hypertension were more cost-sensitive (p\u3c0.001). CONCLUSION: These analyses provide a framework for elucidating individual-level preferences when implementing novel patient-centred interventions. The data showed that patient preference in Personalised Trials is highly variable, suggesting that individual differences must be accounted for when marketing Personalised Trials. These results have implications for advancing precise interventions in Personalised Trials by indicating when rigorous scientific principles, such as frequent monitoring, is feasible in a substantial subset of patients

Design and baseline data from the vanguard of the Comparison of Depression Interventions after Acute Coronary Syndrome (CODIACS) randomized controlled trial

This paper describes the rationale and design of the vanguard for the Comparison of Depression Interventions after Acute Coronary Syndrome (CODIACS), a multicenter, randomized, controlled trial of a patient preference‐based, stepped care protocol for persistent depressive symptoms after acute coronary syndrome (ACS). The overall aim of the vanguard phase was to determine whether the patient-preference, stepped care protocol, which is based on the intervention used in the recent Coronary Psychosocial Evaluation Studies (COPES) trial, was feasible in patients with recent ACS who were recruited from 5 geographically diverse sites. Innovative design features of this trial include randomization to either initial patient-preference of treatment or to a referred care arm in which the primary care provider decided upon care. Additionally, delivery of psychotherapy was accomplished by telephone, or webcam, depending upon patient preference. The vanguard phase provides estimates of eligibility and screening/enrollment ratios, patient acceptance of screening, and retention. In this report, we describe the innovative features and the baseline results of the vanguard phase of CODIACS. The data from this vanguard study will be used to finalize planning for a large, phase III clinical trial designed to evaluate the effect of treatment on depressive symptoms, coronary events, and death

Centralized, Stepped, Patient Preference–Based Treatment for Patients With Post–Acute Coronary Syndrome Depression

IMPORTANCE: Controversy remains about whether depression can be successfully managed after acute coronary syndrome (ACS) and the costs and benefits of doing so. OBJECTIVE: To determine the effects of providing post-ACS depression care on depressive symptoms and health care costs. DESIGN: Multicenter randomized controlled trial. SETTING: Patients were recruited from 2 private and 5 academic ambulatory centers across the United States. PARTICIPANTS: A total of 150 patients with elevated depressive symptoms (Beck Depression Inventory [BDI] score ≥10) 2 to 6 months after an ACS, recruited between March 18, 2010, and January 9, 2012. INTERVENTIONS: Patients were randomized to 6 months of centralized depression care (patient preference for problem-solving treatment given via telephone or the Internet, pharmacotherapy, both, or neither), stepped every 6 to 8 weeks (active treatment group; n = 73), or to locally determined depression care after physician notification about the patient's depressive symptoms (usual care group; n = 77). MAIN OUTCOME MEASURES: Change in depressive symptoms during 6 months and total health care costs. RESULTS: Depressive symptoms decreased significantly more in the active treatment group than in the usual care group (differential change between groups, -3.5 BDI points; 95% CI, -6.1 to -0.7; P = .01). Although mental health care estimated costs were higher for active treatment than for usual care, overall health care estimated costs were not significantly different (difference adjusting for confounding, -$325; 95$2639 to $1989; P = .78). CONCLUSIONS: For patients with post-ACS depression, active treatment had a substantial beneficial effect on depressive symptoms. This kind of depression care is feasible, effective, and may be cost-neutral within 6 months; therefore, it should be tested in a large phase 3 pragmatic trial. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01032018

Astronomy and astrophysics abstracts: literature 1985, part 1

Astronomy and Astrophysics Abstracts aims to present a comprehensive documen­ tation of the literature concerning all aspects of astronomy, astrophysics, and their border fields. It is devoted to the recording, summarizing, and indexing of the relevant publications throughout the world. Astronomy and Astrophysics Abstracts is prepared by a special department of the Astronomisches Rechen-Institut under the auspices of the International Astronomical Union. Volume 39 records literature published in 1985 and received before August 15, 1985. Some older documents which we received late and which are not surveyed in earlier volumes are included too. We acknowledge with thanks contributions of our colleagues all over the world. We also express our gratitude to all organiza­ tions, observatories, and publishers which provide us with complimentary copies of their publications. On account of the introduction of an object index the scope of index information will be considerably enlarged beginning with this volume. In connection with the subject index an additional source to satisfy the needs of retrieval is opened up. Starting with Volume 33, all the recording, correction, and data processing work was done by means of computers. The recording was done by our technical staff members Ms. Helga Ballmann, Ms. Mona El-Choura, Ms. Monika Kohl, Ms. Sylvia Matyssek. Ms. Karin Burkhardt, Ms. Susanne Schlotelburg, and Mr. Stefan Wagner supported our task by careful proofreading. It is a pleasure to thank them all for their encouragement. Heidelberg, September 1985 The Editors Contents Introduction . . . . . . . . . . .

Astronomy and astrophysics abstracts: literature 1982, part 1

Astronomy and Astrophysics Abstracts, which has appeared in semi-annual volumes since 1969, is devoted to the recording, summarizing and indexing of astronomical publications throughout the world. It is prepared under the auspices of the International Astronomical Union (according to a resolution adopted at the 14th General Assembly in 1970). Astronomy and Astrophysics Abstracts aims to present a comprehensive documenta­ tion of literature in all fields of astronomy and astrophysics. Every effort will be made to ensure that the average time interval between the date of receipt of the original literature and publication of the abstracts will not exceed eight months. This time interval is near to that achieved by monthly abstracting journals, compared to which our system of accumu­ lating abstracts for about six months offers the advantage of greater convenience for the user. Volume 31 contains literature published in 1982 and received before July 15, 1982; some older literature which was received late and which is not recorded in earlier volumes is also included. We acknowledge with thanks contributions to this volume by Dr. J. Bouska, Prague, who surveyed journals and publications in Czech and supplied us with abstracts in English

Astronomy and astrophysics abstracts: literature 1983, part 2

Astronomy and Astrophysics Abstracts aims to present a comprehensive documen­ tation of the literature concerning all aspects of astronomy, astrophysics, and their border fields. It is devoted to the recording, summarizing, and indexing of the relevant publications throughout the world. Astronomy and Astrophysics Abstracts is prepared by a special department of the Astronomisches Rechen-Institut under the auspices of the International Astronomical Union. Volume 34 records literature published in 1983 and received before February 17, 1984. Some older documents which we received late and which are not surveyed in earlier volumes are included too. We acknowledge with thanks contributions of our colleagues all over the world. We also express our gratitude to all organiza­ tions, observatories, and publishers which provide us with complimentary copies of their publications. Starting with Volume 33, all the recording, correction, and data processing work was done by means of computers. The recording was done by our technical staff members Ms. Helga Ballmann, Ms. Mona El-Choura and Ms. Monika Kohl. Mr. Martin Schlotelburg and Mr. Ulrich Oberall supported our task by careful proofreading. It is a pleasure to thank them all for their encouragement. Heidelberg, March 1984 The Editors Contents Introduction . . . . . . . . . . . . Concordance Relation: ICSU-AB-AAA 3 Abbreviations 10 Periodicals, Proceedings, Books, Activities 001 Periodicals . . . . . . . . . . . 15 002 Bibliographical Publications, Documentation, Catalogues, Atlases 50 003 Books ...... . 58 004 History of Astronomy 67 005 Biography . . 71 006 Personal Notes 73 007 Obituaries . .