1,009 research outputs found
Arctic Ice Export Events and Their Potential Impact on Global Climate During the Late Pleistocene
Ice sheets in the North American Arctic and, to a lesser extent, those in northern Eurasia calved large quantities of icebergs that drifted through Fram Strait into the Greenland Sea several times during the late Pleistocene. These icebergs deposited Fe oxide grains (45-250 mum) and coarse lithic clasts \u3e250 mum matched to specific circum-Arctic sources. Four massive Arctic iceberg export events are identified from the Laurentide and the Innuitian ice sheets, between 14 and 34 ka (calendar years) in a sediment core from Fram Strait. These relatively short duration (\u3c1-4 kyr) events contain 3-5 times the background levels of Fe oxide grains. They began suddenly, as indicated by a steep rise in the number of grains matched to an ice sheet source, suggesting rapid purges of ice through Fram Strait, due perhaps to collapse of ice sheets. The larger events from the northwestern Laurentide ice sheet are preceded by events from the Innuitian ice sheet. Despite the chronological uncertainties, the Arctic export events appear to occur prior to Heinrich events
Arctic ice export events and their potential impact on global climate during the late Pleistocene
Ice sheets in the North American Arctic and, to a lesser extent, those in northern Eurasia calved large
quantities of icebergs that drifted through Fram Strait into the Greenland Sea several times during the late
Pleistocene. These icebergs deposited Fe oxide grains (45–250 mm) and coarse lithic clasts >250 mm matched to
specific circum-Arctic sources. Four massive Arctic iceberg export events are identified from the Laurentide and
the Innuitian ice sheets, between 14 and 34 ka (calendar years) in a sediment core from Fram Strait. These
relatively short duration (<1–4 kyr) events contain 3–5 times the background levels of Fe oxide grains. They
began suddenly, as indicated by a steep rise in the number of grains matched to an ice sheet source, suggesting
rapid purges of ice through Fram Strait, due perhaps to collapse of ice sheets. The larger events from the
northwestern Laurentide ice sheet are preceded by events from the Innuitian ice sheet. Despite the chronological
uncertainties, the Arctic export events appear to occur prior to Heinrich events
Gaze Restriction and Reactivation of Place-bound Content Drive Eye Movements During Mental Imagery
When we imagine a picture, we move our eyes even though the picture is physically not present. These eye movements provide information about the ongoing process of mental imagery. Eye movements unfold over time, and previous research has shown that the temporal gaze dynamics of eye movements in mental imagery have unique properties, which are unrelated to those in perception. In mental imagery, refixations of previously fixated locations happen more often and in a more systematic manner than in perception. The origin of these unique properties remains unclear. We tested how the temporal structure of eye movements is influenced by the complexity of the mental image. Participants briefly saw and then maintained a pattern stimulus, consisting of one (easy condition) to four black segments (most difficult condition). When maintaining a simple pattern in imagery, participants restricted their gaze to a narrow area, and for more complex stimuli, eye movements were more spread out to distant areas. At the same time, fewer refixations were made in imagery when the stimuli were complex. The results show that refixations depend on the imagined content. While fixations of stimulus-related areas reflect the so-called ‘looking at nothing’ effect, gaze restriction emphasizes differences between mental imagery and perception
Improving the chance of cure of follicular lymphoma by combining immunotherapy and radioimmunotherapy based on anti-CD20 antibodies?
Detecting Generalized Synchronization Between Chaotic Signals: A Kernel-based Approach
A unified framework for analyzing generalized synchronization in coupled
chaotic systems from data is proposed. The key of the proposed approach is the
use of the kernel methods recently developed in the field of machine learning.
Several successful applications are presented, which show the capability of the
kernel-based approach for detecting generalized synchronization. It is also
shown that the dynamical change of the coupling coefficient between two chaotic
systems can be captured by the proposed approach.Comment: 20 pages, 15 figures. massively revised as a full paper; issues on
the choice of parameters by cross validation, tests by surrogated data, etc.
are added as well as additional examples and figure
Neurofilament light chain, a biomarker for polyneuropathy in systemic amyloidosis
OBJECTIVE: To study serum neurofilament light chain (sNfL) in amyloid light chain (AL) amyloidosis patients with and without polyneuropathy (PNP) and to corroborate previous observations that sNfL is increased in hereditary transthyretin-related (ATTRv) amyloidosis patients with PNP. METHODS: sNfL levels were assessed retrospectively in patients with AL amyloidosis with and without PNP (AL/PNP+ and AL/PNP-, respectively), patients with ATTRv amyloidosis and PNP (ATTRv/PNP+), asymptomatic transthyretin (TTR) gene mutation carriers (TTRv carriers) and healthy controls. Healthy controls (HC) were age- and sex-matched to both AL/PNP- (HC/AL) and TTRv carriers (HC/TTRv). The single-molecule array (Simoa) assay was used to assess sNfL levels. RESULTS: sNfL levels were increased both in 10 AL/PNP+ patients (p  I) had the highest sNfL levels compared to patients with early PNP (PND-score I) (p = .05). sNfL levels did not differ between TTRv carriers and HC/TTRv individuals. In the group comprising all healthy controls and in the group of TTRv carriers, sNfL levels correlated with age. CONCLUSION: sNfL levels are increased in patients with PNP in both AL and ATTRv amyloidosis and are related to severity of PNP in ATTRv amyloidosis. sNfL is a promising biomarker to detect PNP, not only in ATTRv but also in AL amyloidosis
Ultrafast optical generation of coherent phonons in CdTe1-xSex quantum dots
We report on the impulsive generation of coherent optical phonons in
CdTe0.68Se0.32 nanocrystallites embedded in a glass matrix. Pump probe
experiments using femtosecond laser pulses were performed by tuning the laser
central energy to resonate with the absorption edge of the nanocrystals. We
identify two longitudinal optical phonons, one longitudinal acoustic phonon and
a fourth mode of a mixed longitudinal-transverse nature. The amplitude of the
optical phonons as a function of the laser central energy exhibits a resonance
that is well described by a model based on impulsive stimulated Raman
scattering. The phases of the coherent phonons reveal coupling between
different modes. At low power density excitations, the frequency of the optical
coherent phonons deviates from values obtained from spontaneous Raman
scattering. This behavior is ascribed to the presence of electronic impurity
states which modify the nanocrystal dielectric function and, thereby, the
frequency of the infrared-active phonons
LISA observations of massive black hole mergers: event rates and issues in waveform modelling
The observability of gravitational waves from supermassive and
intermediate-mass black holes by the forecoming Laser Interferometer Space
Antenna (LISA), and the physics we can learn from the observations, will depend
on two basic factors: the event rates for massive black hole mergers occurring
in the LISA best sensitivity window, and our theoretical knowledge of the
gravitational waveforms. We first provide a concise review of the literature on
LISA event rates for massive black hole mergers, as predicted by different
formation scenarios. Then we discuss what (in our view) are the most urgent
issues to address in terms of waveform modelling. For massive black hole binary
inspiral these include spin precession, eccentricity, the effect of high-order
Post-Newtonian terms in the amplitude and phase, and an accurate prediction of
the transition from inspiral to plunge. For black hole ringdown, numerical
relativity will ultimately be required to determine the relative quasinormal
mode excitation, and to reduce the dimensionality of the template space in
matched filtering.Comment: 14 pages, 2 figures. Added section with conclusions and outlook.
Matches version to appear in the proceedings of 10th Annual Gravitational
Wave Data Analysis Workshop (GWDAW 10), Brownsville, Texas, 14-17 Dec 200
Is Mislocalization during saccades related to the position of the saccade target within the image or to the gaze position at the end of the saccade?
A stimulus that is flashed around the time of a saccade tends to be mislocalized in the direction of the saccade target. Our question is whether the mislocalization is related to the position of the saccade target within the image or to the gaze position at the end of the saccade. We separated the two with a visual illusion that influences the perceived distance to the target of the saccade and thus saccade endpoint without affecting the perceived position of the saccade target within the image. We asked participants to make horizontal saccades from the left to the right end of the shaft of a Müller-Lyer figure. Around the time of the saccade, we flashed a bar at one of five possible positions and asked participants to indicate its location by touching the screen. As expected, participants made shorter saccades along the fins-in (<->) configuration than along the fins-out (>-<) configuration of the figure. The illusion also influenced the mislocalization pattern during saccades, with flashes presented with the fins-out configuration being perceived beyond flashes presented with the fins-in configuration. The difference between the patterns of mislocalization for bars flashed during the saccade for the two configurations corresponded quantitatively with a prediction based on compression towards the saccade endpoint considering the magnitude of the effect of the illusion on saccade amplitude. We conclude that mislocalization is related to the eye position at the end of the saccade, rather than to the position of the saccade target within the image
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