Spectrum of pheochromocytoma in the 131 I-MIBG era

131 I-metaiodobenzylguanidine ( 131 I-MIBG) scintigraphy allows for both functional diagnosis and anatomical localization of pheochromocytoma. The spectrum of pheochromocytoma since the routine use of preoperative 131 I-MIBG scan was studied. From 1980 to 1986, a total of 34 patients were primarily diagnosed and treated at the University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. There were 16 males and 18 females. The mean age was 38 years and 4 patients (11.8%) were under 18 years of age. Six patients (17.6%) had family history of pheochromocytoma or multiple endocrine neoplasia (MEN) II syndrome. The presenting symptoms were hypertension in 29 patients (85.3%); attacks of headache, palpitation, sweating, and flushing in 4 (11.8%), and 1 patient presented with a neck mass. Plasma catecholamines were elevated in 97% of patients while urinary catecholamines and metabolites were elevated in 93.5%. 131 I-MIBG was accurate in 82.3%, partly positive in 11.8%, and false-negative in 5.9% of patients. CT scan was accurate in 80%, partly positive in 10%, but failed to show the tumor in another 10% of patients. At operation, extraadrenal lesions were found in 38.2% of the patients and among these, one-third were extraabdominal. Multiple tumors occurred in 5 (14.7%), and bilateral adrenal lesions occurred in 4 patients (11.8%). Malignancy was diagnosed in 3 patients (8.8%) after an average follow-up period of 2 years. We conclude that the use of routine preoperative 131 I-MIBG scanning improves localization of pheochromocytoma and earlier diagnosis is possible in patients with MEN II syndrome. Multiple tumors, extraadrenal and extraabdominal lesions occur more often than commonly believed. The low rate of confirmed malignancy is probably related to the short period of follow-up. La scintigraphie à l' 131 I-MIBG permet de diagnostiquer et de localiser les phéochromocytomes. Toute la gamme de types de phéochromocytomes reconnu depuis l'utilisation préopératoire systématique de la scintigraphie à l' 131 I-MIBG est présentée. Entre 1980 et 1986, 34 patients ont été explorés et traités au Centre Médical de l'Université de Michigan, Ann Arbor, Michigan. Il y avait 16 hommes et 18 femmes. L'âge moyen était de 38 ans, et 4 patients (11.8%) avaient moins de 18 ans. Six patients (17.6%) avaient des antécédents familiaux de phéochromocytome ou de néoplasmes endocrines multiples (MEN) du type II. Les symptômes amenant à consulter étaient l'hypertension chez 29 patients (85.3%), des crises de céphalées, des palpitations et un flush chez 4 patients (11.8%); un patient présentait une masse cervicale. Les catécholamines plasmatiques étaient élevées chez 97% des patients alors que les catécholamines et leurs métabolites étaient en quantité élevée chez 93.5% des patients. La scintigraphie à l' 131 I-MIBG était positive chez 82.3%, partiellement positive chez 11.8%, et faussement négative chez 5.9% des patients. La tomodensitométrie était positive chez 80%, partiellement positive chez 10%, et faussement négative chez 10% des patients. A l'intervention, des lésions extra-surrénales étaient présentes dans 38.2% des cas, et parmi celles-ci, un tiers étaient extra-abdominales. Les tumeurs étaient multiples dans 5 cas (14.7%), et bilatérales surrénales dans 4 cas (11.8%). Une tumeur maligne était diagnostiquée chez 3 patients (8.8%), après une période de suivi de 2 ans en moyenne. Nous concluons que l'utilisation systématique de la scintigraphie à l' 131 I-MIBG améliore la localisation des phéochromocytomes, permettant un diagnostic plus précoce chez les patients présentant un syndrome MEN II. La multiplicité tumorale et les localisations extra-médullosurrénales ou extra-abdominales se voient beaucoup plus fréquemment qu'on le pensait auparavant. Le taux de malignité peu élevé était probablement en rapport avec la courte période de suivi. La escintigrafía con 131 I-MIBG permite tanto la localización anatómica como el diagnóstico funcional del feocromocitoma. Las características o espectro del feocromocitoma a partir del uso rutinario de 131 I-MIBG han sido estudiadas.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41282/1/268_2005_Article_BF01655447.pd

Sadržaj toksičnih i esencijalnih metala u ljekovitom bilju koje raste u onečišćenim i neonečišćenim područjima u Makedoniji

The aim of this study was to determine and compare Ba, Cr, Cd, Fe, Sr, Pb, and Zn content in medicinal herbs Urtica dioica L., Taraxacum officinale, and Matricaria recutita growing in polluted and unpolluted areas of the Republic of Macedonia. The metal content was determined using inductively coupled plasma atomic emission spectroscopy (ICP-AES). In the unpolluted area of Mt. Plačkovica the metal content in Taraxacum officinale was in the descending order: Fe>Sr>Zn>Ba>Cr, while Pb and Cd were below the limit of detection. In the polluted area of Veles, the order was as follows: Fe>Zn>Sr>Pb>Ba>Cd>Cr. Our results suggest that quality assurance and monitoring of toxic metals is needed for plants intended for human use and consumption. Medicinal plants should be picked in areas free of any contamination sources.Cilj je ovoga istraživanja bio utvrditi i usporediti sadržaj Ba, Cr, Cd, Fe, Sr, Pb i Zn u ljekovitom bilju Urtica dioica L., Taraxacum offi cinale i Matricaria recutita koje raste u onečišćenome odnosno neonečišćenome području u Republici Makedoniji. Sadržaj metala utvrdili smo s pomoću atomske emisijske spektroskopije induktivno spregnutom plazmom (engl. inductively coupled plasma atomic emission spectroscopy, krat. ICP-AES). U neonečišćenome području planine Plačkovice, sadržaj metala u Taraxacum offi cinale kretao se kako slijedi: Fe>Sr>Zn>Ba>Cr, dok su Pb i Cd bili ispod granice detekcije. U onečišćenome području blizu talionice olova i cinka u Velesu redoslijed je bio ovakav: Fe>Zn>Sr>Pb>Ba>Cd>Cr. Naši rezultati upućuju na potrebu za osiguranjem kakvoće i praćenjem razina toksičnih metala u biljaka namijenjenih ljudskoj uporabi. Ljekovito bilje valja brati u područjima bez izvora onečišćenja

Ocena stopnia zanieczyszczenia srodowiska siarka i olowiem w poblizu zrodla emisji, na podstawie okreslenia ich akumulacji w iglach sosny zwyczajnej

W latach 1986 i 2004 przeprowadzono badania, których celem było porównanie stopnia zanieczyszczenia środowiska ołowiem oraz dwutlenkiem siarki w okolicach Huty Luccioni. Posłużono się metodą bioindykacyjną, polegającą na określeniu wielkości akumulacji ołowiu oraz dwutlenku siarki w igłach sosny zwyczajnej (Pinus silvestris L.). Uzyskane wyniki badań wskazują na znaczne zmniejszenie się zanieczyszczenia środowiska ołowiem. Nie stwierdzono natomiast istotnych różnic w poziomie zanieczyszczenia siarką. Zarówno w 1986, jak i w 2004, był on wysoki. Zanieczyszczenie środowiska ołowiem i dwutlenkiem siarki w rejonie Huty Luccini było znacznie wyższe w stosunku do pozostałych części Warszawy w obu latach.In 1986 and 2004 research works were carried out to compare the level of environmental pollution with lead and sulfur around the Luccini Steelworks in Warsaw. The method of bioindication, which involves the assesment of lead and sulfur accumulation in Scotch pine needles, was used. The results indicate a substantial decrease in environmental pollution with lead. However, there was no significant difference in the level of pollution with sulfur which remained high in both years. Both years the environmental pollution with sulfur and lead in the area of Luccini Steelworks was much higher as compared with the rest of Warsaw

Biomonitoring for air pollution evaluation of countryside and urban areas

Meeting: World Commission on Environment and Development, Public Hearing, 8, 11 Dec. 1986, Moskva, SURelated to DAP 87-4249 under which IDRC supported the WCED to acquire and duplicate original papers, submissions, tapes and transcripts, became the depository of all original archival materials and received the right to microfiche the collection for broader disseminatio

Anatomy of abscission zone of Betula pendula (Roth.) leaves from trees growing under different levels of pollution

A study was carried out on the leaf abscission zone from birch trees growing on polluted sites (two) and a non-polluted site (one). Samples for anatomical investigation were collected from six trees on each site, during three succeeding vegetation seasons. It was observed that in trees growing at the polluted sites: 1) maturation of the abscission zone was faster, 2) the protective layer was thinner and 3) the formation of leaf scar periderm was delayed in comparison with trees from the non-polluted site. The results obtained suggest that environmental pollution influences the formation of the abscission zone and the protection of the leaf scar

Zawartość wybranych pierwiastków w siewkach linii wsobnych żyta ozimego (Secale cereale L.)

9 inbred lines were chosen for the experiment (L176, L230, CH7, L154, M353, L4, L299, L310, L28) of the winter rye S25 generation (Secale cereale L.). The 5 day-old seedlings of the line were treated with a cadmium sulfate solution at a concentration of 10–6 and 10–4 M for 36 h, and then placed on the Hoagland nutrient. The control materials were comprised of seedlings of the line growing on the same nutrient. The twenty-one day old seedlings were mineralized and the content of the following elements was marked: cadmium, magnesium, zinc, calcium, manganese and potassium, using the Perkin-Elmer1100 atomic absorption spectrophotometer. The lowest content of cadmium amounting to several mg/kg was observed in the control combination. The content of chemical elements in all inbred lines was higher at a lower concentration of cadmium 10–6 M/36 h (with the exception of L230 and L299 line).Do doświadczenia wybrano 9 linii wsobnych (L176, L230, CH7, L154, M353, L4, L299, L310 i L29) pokolenia S25 żyta ozimego (Secale cereale L.). Pięciodniowe siewki linii traktowano roztworem siarczanu kadmu o stężeniach 10-6 i 10-4 M przez 36 h, a następnie przenoszono je na pożywkę. Materiał kontrolny stanowiły siewki linii rosnące na pożywce Hoaglanda. Dwudziestojednodniowe siewki mineralizowano i oznaczono zawartość następujących pierwiastków: kadm, magnez, cynk, wapń, mangan i potas, przy użyciu spektrofotometru absorpcji atomowej firmy Perkin-Elmer1100. Najniższą zawartość kadmu wynoszącą kilka mg/kg zanotowano w kombinacji kontrolnej. Zawartość biogennych pierwiastków była wyższa u wszystkich linii wsobnych żyta w niższym stężeniu kadmu 10-6 M/36 h (z wyjątkiem linii L230 i L299)