309 research outputs found
On the Prior Sensitivity of Thompson Sampling
The empirically successful Thompson Sampling algorithm for stochastic bandits
has drawn much interest in understanding its theoretical properties. One
important benefit of the algorithm is that it allows domain knowledge to be
conveniently encoded as a prior distribution to balance exploration and
exploitation more effectively. While it is generally believed that the
algorithm's regret is low (high) when the prior is good (bad), little is known
about the exact dependence. In this paper, we fully characterize the
algorithm's worst-case dependence of regret on the choice of prior, focusing on
a special yet representative case. These results also provide insights into the
general sensitivity of the algorithm to the choice of priors. In particular,
with being the prior probability mass of the true reward-generating model,
we prove and regret upper bounds for the
bad- and good-prior cases, respectively, as well as \emph{matching} lower
bounds. Our proofs rely on the discovery of a fundamental property of Thompson
Sampling and make heavy use of martingale theory, both of which appear novel in
the literature, to the best of our knowledge.Comment: Appears in the 27th International Conference on Algorithmic Learning
Theory (ALT), 201
Efficient approximate thompson sampling for search query recommendation
Query suggestions have been a valuable feature for e-commerce sites in helping shoppers refine their search intent. In this paper, we develop an algorithm that helps e-commerce sites like eBay mingle the output of different recommendation al-gorithms. Our algorithm is based on âThompson Samplingâ â a technique designed for solving multi-arm bandit prob-lems where the best results are not known in advance but instead are tried out to gather feedback. Our approach is to treat query suggestions as a competition among data re-sources: we have many query suggestion candidates compet-ing for limited space on the search results page. An âarmâ is played when a query suggestion candidate is chosen for display, and our goal is to maximize the expected reward (user clicks on a suggestion). Our experiments have shown promising results in using the click-based user feedback to drive success by enhancing the quality of query suggestions
Structure and Melting of Two-Species Charged Clusters in a Parabolic Trap
We consider a system of charged particles interacting with an unscreened
Coulomb repulsion in a two-dimensional parabolic confining trap. The static
charge on a portion of the particles is twice as large as the charge on the
remaining particles. The particles separate into a shell structure with those
of greater charge situated farther from the center of the trap. As we vary the
ratio of the number of particles of the two species, we find that for certain
configurations, the symmetry of the arrangement of the inner cluster of
singly-charged particles matches the symmetry of the outer ring of
doubly-charged particles. These matching configurations have a higher melting
temperature and a higher thermal threshold for intershell rotation between the
species than the nonmatching configurations.Comment: 4 pages, 6 postscript figure
Yield conditions for deformation of amorphous polymer glasses
Shear yielding of glassy polymers is usually described in terms of the
pressure-dependent Tresca or von Mises yield criteria. We test these criteria
against molecular dynamics simulations of deformation in amorphous polymer
glasses under triaxial loading conditions that are difficult to realize in
experiments. Difficulties and ambiguities in extending several standard
definitions of the yield point to triaxial loads are described. Two
definitions, the maximum and offset octahedral stresses, are then used to
evaluate the yield stress for a wide range of model parameters. In all cases,
the onset of shear is consistent with the pressure-modified von Mises
criterion, and the pressure coefficient is nearly independent of many
parameters. Under triaxial tensile loading, the mode of failure changes to
cavitation.Comment: 9 pages, 8 figures, revte
»Filozofija i krĆĄÄanstvo« »Philosophia et christianita«
This work was undertaken during T.L. Stephensâs PhD studentship, supported by the Central England Natural Environmental Research Council (NERC) Training Alliance (CENTA) [award reference: 1503848]. The authors would like to thank Nicolas Le Corvec and an anonymous reviewer for their helpful comments during the reviewing process. Additionally we would like to thank Craig Magee, Atsushi Yamaji, and an anonymous reviewer for their constructive reviews on an earlier version of the manuscript.Peer reviewedPublisher PD
Hard-core Yukawa model for two-dimensional charge stabilized colloids
The hyper-netted chain (HNC) and Percus-Yevick (PY) approximations are used
to study the phase diagram of a simple hard-core Yukawa model of
charge-stabilized colloidal particles in a two-dimensional system. We calculate
the static structure factor and the pair distribution function over a wide
range of parameters. Using the statics correlation functions we present an
estimate for the liquid-solid phase diagram for the wide range of the
parameters.Comment: 7 pages, 9figure
Brownian motion exhibiting absolute negative mobility
We consider a single Brownian particle in a spatially symmetric, periodic
system far from thermal equilibrium. This setup can be readily realized
experimentally. Upon application of an external static force F, the average
particle velocity is negative for F>0 and positive for F<0 (absolute negative
mobility).Comment: 4 pages, 3 figures, to be published in PR
DepQBF 6.0: A Search-Based QBF Solver Beyond Traditional QCDCL
We present the latest major release version 6.0 of the quantified Boolean
formula (QBF) solver DepQBF, which is based on QCDCL. QCDCL is an extension of
the conflict-driven clause learning (CDCL) paradigm implemented in state of the
art propositional satisfiability (SAT) solvers. The Q-resolution calculus
(QRES) is a QBF proof system which underlies QCDCL. QCDCL solvers can produce
QRES proofs of QBFs in prenex conjunctive normal form (PCNF) as a byproduct of
the solving process. In contrast to traditional QCDCL based on QRES, DepQBF 6.0
implements a variant of QCDCL which is based on a generalization of QRES. This
generalization is due to a set of additional axioms and leaves the original
Q-resolution rules unchanged. The generalization of QRES enables QCDCL to
potentially produce exponentially shorter proofs than the traditional variant.
We present an overview of the features implemented in DepQBF and report on
experimental results which demonstrate the effectiveness of generalized QRES in
QCDCL.Comment: 12 pages + appendix; to appear in the proceedings of CADE-26, LNCS,
Springer, 201
Transition Between Ground State and Metastable States in Classical 2D Atoms
Structural and static properties of a classical two-dimensional (2D) system
consisting of a finite number of charged particles which are laterally confined
by a parabolic potential are investigated by Monte Carlo (MC) simulations and
the Newton optimization technique. This system is the classical analog of the
well-known quantum dot problem. The energies and configurations of the ground
and all metastable states are obtained. In order to investigate the barriers
and the transitions between the ground and all metastable states we first
locate the saddle points between them, then by walking downhill from the saddle
point to the different minima, we find the path in configurational space from
the ground state to the metastable states, from which the geometric properties
of the energy landscape are obtained. The sensitivity of the ground-state
configuration on the functional form of the inter-particle interaction and on
the confinement potential is also investigated
Derivation, validation, and clinical relevance of a pediatric sepsis phenotype with persistent hypoxemia, encephalopathy, and shock
OBJECTIVES: Untangling the heterogeneity of sepsis in children and identifying clinically relevant phenotypes could lead to the development of targeted therapies. Our aim was to analyze the organ dysfunction trajectories of children with sepsis-associated multiple organ dysfunction syndrome (MODS) to identify reproducible and clinically relevant sepsis phenotypes and determine if they are associated with heterogeneity of treatment effect (HTE) to common therapies.
DESIGN: Multicenter observational cohort study.
SETTING: Thirteen PICUs in the United States.
PATIENTS: Patients admitted with suspected infections to the PICU between 2012 and 2018.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: We used subgraph-augmented nonnegative matrix factorization to identify candidate trajectory-based phenotypes based on the type, severity, and progression of organ dysfunction in the first 72 hours. We analyzed the candidate phenotypes to determine reproducibility as well as prognostic, therapeutic, and biological relevance. Overall, 38,732 children had suspected infection, of which 15,246 (39.4%) had sepsis-associated MODS with an in-hospital mortality of 10.1%. We identified an organ dysfunction trajectory-based phenotype (which we termed persistent hypoxemia, encephalopathy, and shock) that was highly reproducible, had features of systemic inflammation and coagulopathy, and was independently associated with higher mortality. In a propensity score-matched analysis, patients with persistent hypoxemia, encephalopathy, and shock phenotype appeared to have HTE and benefit from adjuvant therapy with hydrocortisone and albumin. When compared with other high-risk clinical syndromes, the persistent hypoxemia, encephalopathy, and shock phenotype only overlapped with 50%-60% of patients with septic shock, moderate-to-severe pediatric acute respiratory distress syndrome, or those in the top tier of organ dysfunction burden, suggesting that it represents a nonsynonymous clinical phenotype of sepsis-associated MODS.
CONCLUSIONS: We derived and validated the persistent hypoxemia, encephalopathy, and shock phenotype, which is highly reproducible, clinically relevant, and associated with HTE to common adjuvant therapies in children with sepsis
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