52 research outputs found
Peanutâinduced anaphylaxis in children and adolescents: Data from the European Anaphylaxis Registry
Background Peanut allergy has a rising prevalence in high-income countries, affecting 0.5%-1.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents. Methods Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food-induced anaphylaxis cases in a tertiary paediatric allergy centre. Results 3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; p = .001), asthma comorbidity (47% vs. 35%; p < .001), relevant cofactors (29% vs. 22%; p = .004) and biphasic reactions (10% vs. 4%; p = .001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; p = .001). Self-administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs. 26%; p = .003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; p = .004). Conclusions The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first-line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition
Graph Transformation in Molecular Biology
In the beginning, one of the main fields of application of graph transformation was biology, and more specifically morphology. Later, however, it was like if the biological applications had been left aside by the graph transformation community, just to be moved back into the mainstream these very last years with a new interest in molecular biology. In this paper, we review several fields of application of graph grammars in molecular biology, including: the modeling higherdimensional structures of biomolecules, the description of biochemical reactions, the analysis of metabolic pathways, and their potential use in computational systems biology
Generalised Quantum TheoryâBasic Idea and General Intuition: A Background Story and Overview
Organisationskultur. Eine Konkretisierung aus systemtheoretischer Perspektive
KĂŒhl S. Organisationskultur. Eine Konkretisierung aus systemtheoretischer Perspektive. Managementforschung. 2018;28(1):7-35.Die Bestimmung des VerhĂ€ltnisses von InformalitĂ€t und Organisationskultur bereitet in der Organisationstheorie Schwierigkeiten. Das liegt daran, dass der Begriff InformalitĂ€t hĂ€ufig stillschweigend durch den Begriff der Organisationskultur ersetzt wurde, ohne dass dafĂŒr eine prĂ€zise, abgrenzungsscharfe Definition vorgenommen worden wĂ€re. Unter RĂŒckgriff auf Ăberlegungen von Dario RodrĂguez argumentiert dieser Artikel, dass die beiden Begriffe Organisationskultur und InformalitĂ€t das gleiche PhĂ€nomen bezeichnen: die nichtentschiedenen EntscheidungsprĂ€missen einer Organisation. Dabei wird systematisch zwischen âunentscheidbaren EntscheidungsprĂ€missenâ und âprinzipiell entscheidbaren, aber nicht entschiedenen EntscheidungsprĂ€missenâ unterschieden. Es wird gezeigt, wie sich mit einer prĂ€zisen Bestimmung ĂŒber das Konzept der EntscheidungsprĂ€missen Ordnung in die âwilden Merkmallistenâ der Literatur sowohl ĂŒber InformalitĂ€t als auch Organisationskultur bringen lĂ€sst und empirische PhĂ€nomene genauer erfasst werden können
STUDIES ON THE ROOT DEVELOPMENT OF HERBAGE PLANTS. III. The influence of cutting treatments on the root, stubble and herbage production of Aperennial ryegrass sward.
Looking at proteins: representations, folding, packing, and design. Biophysical Society National Lecture, 1992.
Looking at proteins is an active process of interpretation and selection, emphasizing some features and deleting others. Multiple representations are needed, for such purposes as showing motions or conveying both the chain connectivity and the three-dimensional shape simultaneously. In studying and comparing protein structures, ideas are suggested about the determinants of tertiary structure and of folding (e.g., that Greek key beta barrels may fold up two strands at a time). The design and synthesis of new proteins "from scratch" provides a route toward the experimental testing of such ideas. It has also been a fruitful new perspective from which to look at structures, requiring such things as statistics on very narrowly defined structural categories and explicit attention to "negative design" criteria that actively block unwanted alternatives (e.g., reverse topology of a helix bundle, or edge-to-edge aggregation of beta sheets). Recently, the field of protein design has produced a rather unexpected general result: apparently we do indeed know enough to successfully design proteins that fold into approximately correct structures, but not enough to design unique, native-like structures. The degree of order varies considerably, but even the best designed material shows multiple conformations by NMR, more similar to a "molten globule" folding intermediate than to a well ordered native tertiary structure. In response to this conclusion, we are now working on systems that test useful questions with approximate structures (such as determining which factors most influence the choice of helix-bundle topology) and also analyzing how natural proteins achieve unique core conformations (e.g., for side chains on the interior side of a beta sheet, illustrated in the kinemages)
Theorie und Praxis der Jugendhilfe und Jugendsozialarbeit
Theorie und Praxis der Jugendhilfe und Jugendsozialarbeit. - In: Die Jugend / Helga Reimann ... (Hrsg.). - 2., völlig neu bearb. Aufl. - Opladen : Westdt. Verl., 1987. - S. 219-242. - (WV studium ; 133). - [1. Aufl. 1975
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