Association of N-terminal pro-brain natriuretic peptide with cognitive function and depression in elderly people with type 2 diabetes

<p>Background: Type 2 diabetes mellitus is associated with risk of congestive heart failure (CHF), cognitive dysfunction and depression. CHF itself is linked both to poor cognition and depression. The ventricular N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of CHF, suggesting potential as a marker for cognitive impairment and/or depression. This was tested in the Edinburgh Type 2 Diabetes Study (ET2DS).</p> <p>Methodology and Principal Findings: Cross-sectional analysis of 1066 men and women aged 60–75 with type 2 diabetes. Results from seven neuropsychological tests were combined in a standardised general cognitive ability factor, ‘g’. A vocabulary-based test estimated pre-morbid cognitive ability. The Hospital Anxiety and Depression Scale (HADS) assessed possible depression. After adjustment for age and sex, raised plasma NT-proBNP was weakly associated with lower ‘g’ and higher depression scores (ß −0.09, 95% CI −0.13 to −0.03, p = 0.004 and ß 0.08, 95% CI 0.04 to 0.12, p<0.001, respectively). Comparing extreme quintiles of NT-proBNP, subjects in the highest quintile were more likely to have reduced cognitive ability (within the lowest tertile of ‘g’) and ‘possible’ depression (HADS depression ≥8) (OR 1.80; 95% CI: 1.20, 2.70; p = 0.005 and OR 2.18; 95% CI: 1.28, 3.71; p = 0.004, respectively). Associations persisted when pre-morbid ability was adjusted for, but as expected were no longer statistically significant following the adjustment for diabetes-related and vascular co-variates (β −0.02, 95% CI −0.07 to 0.03, p>0.05 for ‘g’; β 0.03, 95% CI −0.02 to 0.07, p>0.05 for depression scores).</p> <p>Conclusion: Raised plasma NT-proBNP was weakly but statistically significantly associated with poorer cognitive function and depression. The prospective phases of the ET2DS will help determine whether or not NT-proBNP can be considered a risk marker for subsequent cognitive impairment and incident depression and whether it provides additional information over and above traditional risk factors for these conditions.</p&gt

Discovery of 15-second oscillations in Hubble Space Telescope observations of WZ Sagittae following the 2001 outburst

We report the discovery of 15-s oscillations in ultraviolet observations of WZ Sge obtained with the Hubble Space Telescope approximately one month after the peak of the 2001 outburst. This is the earliest detection of oscillations in WZ Sge following an outburst and the first time that a signal near 15 s has been seen to be dominant. The oscillations are quite strong (amplitude about 5%), but not particularly coherent. In one instance, the oscillation period changed by 0.7 s between successive observations separated by less than 1 hour. We have also found evidence for weaker signals with periods near 6.5 s in some of our data. We discuss the implications of our results for the models that have been proposed to account for the 28-s oscillations seen in quiescence. If the periods of the 15-s oscillations can be identified with the periods of revolution of material rotating about the white dwarf, the mass of the white dwarf must satisfy M_WD > 0.71 M_sun. The corresponding limit for the 6.5-s signals is M_WD > 1.03 M_sun.Comment: accepted for publication in ApJ Letters; 13 pages, 4 postscript figures; new version corrects a few typos and matches version that will appear in ApJ

The Computational Complexity of Knot and Link Problems

We consider the problem of deciding whether a polygonal knot in 3-dimensional Euclidean space is unknotted, capable of being continuously deformed without self-intersection so that it lies in a plane. We show that this problem, {\sc unknotting problem} is in {\bf NP}. We also consider the problem, {\sc unknotting problem} of determining whether two or more such polygons can be split, or continuously deformed without self-intersection so that they occupy both sides of a plane without intersecting it. We show that it also is in NP. Finally, we show that the problem of determining the genus of a polygonal knot (a generalization of the problem of determining whether it is unknotted) is in {\bf PSPACE}. We also give exponential worst-case running time bounds for deterministic algorithms to solve each of these problems. These algorithms are based on the use of normal surfaces and decision procedures due to W. Haken, with recent extensions by W. Jaco and J. L. Tollefson.Comment: 32 pages, 1 figur

Hubble Space Telescope Observations of UV Oscillations in WZ Sagittae During the Decline from Outburst

We present a time series analysis of Hubble Space Telescope observations of WZ Sge obtained in 2001 September, October, November and December as WZ Sge declined from its 2001 July superoutburst. Previous analysis of these data showed the temperature of the white dwarf decreased from ~29,000 K to ~18,000 K. In this study we binned the spectra over wavelength to yield ultraviolet light curves at each epoch that were then analyzed for the presence of the well-known 27.87 s and 28.96 s oscillations. We detect the 29 s periodicity at all four epochs, but the 28 s periodicity is absent. The origin of these oscillations has been debated since their discovery in the 1970s and competing hypotheses are based on either white dwarf non-radial g-mode pulsations or magnetically-channelled accretion onto a rotating white dwarf. By analogy with the ZZ Ceti stars, we argue that the non-radial g-mode pulsation model demands a strong dependence of pulse period on the white dwarf's temperature. However, these observations show the 29 s oscillation is independent of the white dwarf's temperature. Thus we reject the white dwarf non-radial g-mode pulsation hypothesis as the sole origin of the oscillations. It remains unclear if magnetically-funnelled accretion onto a rapidly rotating white dwarf (or belt on the white dwarf) is responsible for producing the oscillations. We also report the detection of a QPO with period ~18 s in the September light curve. The amplitudes of the 29 s oscillation and the QPO vary erratically on short timescales and are not correlated with the mean system brightness nor with each other.Comment: 20 pages, 3 figures, 1 table; accepted for publication in Ap

Short-term emission line and continuum variations in Mrk110

We present results of a variability campaign of Mrk110 performed with the 9.2-m Hobby-Eberly Telescope (HET) at McDonald Observatory. The high S/N spectra cover most of the optical range. They were taken from 1999 November through 2000 May. The average interval between the observations was 7.3 days and the median interval was only 3.0 days. Mrk110 is a narrow-line Seyfert 1 galaxy. During our campaign the continuum flux was in a historically low stage. Considering the delays of the emission lines with respect to the continuum variations we could verify an ionization stratification of the BLR. We derived virial masses of the central black hole from the radial distances of the different emission lines and from their widths. The calculated central masses agree within 20%. Furthermore, we identified optical HeI singlet emission lines emitted in the broad-line region. The observed line fluxes agree with theoretical predictions. We show that a broad wing on the red side of the [OIII]5007 line is caused by the HeI singlet line at 5016A.Comment: 11 pages, 16 figures, A&A Latex. Accepted for publication in A&A Main Journa

Identification of a nearby stellar association in the Hipparcos catalog: implications for recent, local star formation

The TW Hydrae Association (~55 pc from Earth) is the nearest known region of recent star formation. Based primarily on the Hipparcos catalog, we have now identified a group of 9 or 10 co-moving star systems at a common distance (~45 pc) from Earth that appear to comprise another, somewhat older, association (``the Tucanae Association''). Together with ages and motions recently determined for some nearby field stars, the existence of the Tucanae and TW Hydrae Associations suggests that the Sun is now close to a region that was the site of substantial star formation only 10-40 million years ago. The TW Hydrae Association represents a final chapter in the local star formation history.Comment: 5 pages incl figs and table

Prospects for the Characterization and Confirmation of Transiting Exoplanets via the Rossiter-McLaughlin Effect

The Rossiter-McLaughlin (RM) effect is the distortion of stellar spectral lines that occurs during eclipses or transits, due to stellar rotation. We assess the future prospects for using the RM effect to measure the alignment of planetary orbits with the spin axes of their parent stars, and to confirm exoplanetary transits. We compute the achievable accuracy for the parameters of interest, in general and for the 5 known cases of transiting exoplanets with bright host stars. We determine the requirements for detecting the effects of differential rotation. For transiting planets with small masses or long periods (as will be detected by forthcoming satellite missions), the velocity anomaly produced by the RM effect can be much larger than the orbital velocity of the star. For a terrestrial planet in the habitable zone of a Sun-like star found by the Kepler mission, it will be difficult to use the RM effect to confirm transits with current instruments, but it still may be easier than measuring the spectroscopic orbit.Comment: 18 pages, 8 figures, one table. Minor changes. Accepted to ApJ, to appear in the Jan 20, 2007 issue (v655

On a Site of X-ray Emission in AE Aquarii

An analysis of recently reported results of XMM-Newton observations of AE Aqr within a hypothesis that the detected X-ray source is located inside the Roche lobe of the white dwarf is presented. I show this hypothesis to be inconsistent with the currently adopted model of mass-transfer in the system. Possible solutions of this problem are briefly discussed.Comment: 4 pages, accepted for publication in ApJ Letter