The economic impacts of climate change: Evidence from agricultural output and random fluctuations in weather: Comment

In a series of studies employing a variety of approaches, we have found that the potential impact of climate change on US agriculture is likely negative. Deschênes and Greenstone (2007) report dramatically different results based on regressions of agricultural profits and yields on weather variables. The divergence is explained by (1) missing and incorrect weather and climate data in their study; (2) their use of older climate change projections rather than the more recent and less optimistic projections from the Fourth Assessment Report; and (3) difficulties in their profit measure due to the confounding effects of storage

The Upregulation of α2δ-1 Subunit Modulates Activity-Dependent Ca2+ Signals in Sensory Neurons.

As auxiliary subunits of voltage-gated Ca(2+) channels, the α2δ proteins modulate membrane trafficking of the channels and their localization to specific presynaptic sites. Following nerve injury, upregulation of the α2δ-1 subunit in sensory dorsal root ganglion neurons contributes to the generation of chronic pain states; however, very little is known about the underlying molecular mechanisms. Here we show that the increased expression of α2δ-1 in rat sensory neurons leads to prolonged Ca(2+) responses evoked by membrane depolarization. This mechanism is coupled to CaV2.2 channel-mediated responses, as it is blocked by a ω-conotoxin GVIA application. Once initiated, the prolonged Ca(2+) transients are not dependent on extracellular Ca(2+) and do not require Ca(2+) release from the endoplasmic reticulum. The selective inhibition of mitochondrial Ca(2+) uptake demonstrates that α2δ-1-mediated prolonged Ca(2+) signals are buffered by mitochondria, preferentially activated by Ca(2+) influx through CaV2.2 channels. Thus, by controlling channel abundance at the plasma membrane, the α2δ-1 subunit has a major impact on the organization of depolarization-induced intracellular Ca(2+) signaling in dorsal root ganglion neurons

Engineered T cell therapies.

Alongside advancements in gene therapy for inherited immune disorders, the need for effective alternative therapeutic options for other conditions has resulted in an expansion in the field of research for T cell gene therapy. T cells are easily obtained and can be induced to divide robustly ex vivo, a characteristic that allows them to be highly permissible to viral vector-mediated introduction of transgenes. Pioneering clinical trials targeting cancers and infectious diseases have provided safety and feasibility data and important information about persistence of engineered cells in vivo. Here, we review clinical experiences with γ-retroviral and lentiviral vectors and consider the potential of integrating transposon-based vectors as well as specific genome editing with designer nucleases in engineered T cell therapies

AGN-starburst evolutionary connection: a physical interpretation based on radiative feedback

Observations point towards a close connection between nuclear starbursts, active galactic nuclei (AGN), and outflow phenomena. An evolutionary sequence, starting from a dust-obscured ultra-luminous infrared galaxy and eventually leading to an unobscured optical quasar, has been proposed and discussed in the literature. AGN feedback is usually invoked to expel the obscuring gas and dust in a blow-out event, but the underlying physical mechanism remains unclear. We consider AGN feedback driven by radiation pressure on dust, which directly acts on the obscuring dusty gas. We obtain that radiative feedback can potentially disrupt dense gas in the infrared-optically thick regime, and that an increase in the dust-to-gas fraction leads to an increase in the effective Eddington ratio. Thus, the more dusty gas is preferentially expelled by radiative feedback, and the central AGN is prone to efficiently remove its own obscuring dust cocoon. Large amounts of dust imply heavy obscuration but also powerful feedback, suggesting a causal link between dust obscuration and blow-out. In this picture, AGN feedback and starburst phenomena are intrinsically coupled through the production of dust in supernova explosions, leading to a natural interpretation of the observed evolutionary path.WI acknowledges support from the Swiss National Science Foundation and ACF acknowledges support from ERC Advanced Grant 340442

Ultramassive black hole feedback in compact galaxies

Recent observations confirm the existence of ultra-massive black holes (UMBH) in the nuclei of compact galaxies, with physical properties similar to NGC 1277. The nature of these objects poses a new puzzle to the `black hole-host galaxy co-evolution' scenario. We discuss the potential link between UMBH and galaxy compactness, possibly connected via extreme active galactic nucleus (AGN) feedback at early times ($z > 2$). In our picture, AGN feedback is driven by radiation pressure on dust. We suggest that early UMBH feedback blows away all the gas beyond a $\sim$kpc or so, while triggering star formation at inner radii, eventually leaving a compact galaxy remnant. Such extreme UMBH feedback can also affect the surrounding environment on larger scales, e.g. the outflowing stars may form a diffuse stellar halo around the compact galaxy, or even escape into the intergalactic or intracluster medium. On the other hand, less massive black holes will drive less powerful feedback, such that the stars formed within the AGN feedback-driven outflow remain bound to the host galaxy, and contribute to its size growth over cosmic time.Comment: accepted for publication in MNRA

Solving QCD evolution equations in rapidity space with Markovian Monte Carlo

This work covers methodology of solving QCD evolution equation of the parton distribution using Markovian Monte Carlo (MMC) algorithms in a class of models ranging from DGLAP to CCFM. One of the purposes of the above MMCs is to test the other more sophisticated Monte Carlo programs, the so-called Constrained Monte Carlo (CMC) programs, which will be used as a building block in the parton shower MC. This is why the mapping of the evolution variables (eikonal variable and evolution time) into four-momenta is also defined and tested. The evolution time is identified with the rapidity variable of the emitted parton. The presented MMCs are tested independently, with ~0.1% precision, against the non-MC program APCheb especially devised for this purpose.Comment: version compatible with with the erratum in Acta Physica Polonic

A Rule-Based Approach to Analyzing Database Schema Objects with Datalog

Database schema elements such as tables, views, triggers and functions are typically defined with many interrelationships. In order to support database users in understanding a given schema, a rule-based approach for analyzing the respective dependencies is proposed using Datalog expressions. We show that many interesting properties of schema elements can be systematically determined this way. The expressiveness of the proposed analysis is exemplarily shown with the problem of computing induced functional dependencies for derived relations. The propagation of functional dependencies plays an important role in data integration and query optimization but represents an undecidable problem in general. And yet, our rule-based analysis covers all relational operators as well as linear recursive expressions in a systematic way showing the depth of analysis possible by our proposal. The analysis of functional dependencies is well-integrated in a uniform approach to analyzing dependencies between schema elements in general.Comment: Pre-proceedings paper presented at the 27th International Symposium on Logic-Based Program Synthesis and Transformation (LOPSTR 2017), Namur, Belgium, 10-12 October 2017 (arXiv:1708.07854

The species of Sphaerolobium (Fabaceae) in Tasmania

Two species of the globe pea Sphaerolobium occur in Tasmania: Sphaerolobium minus Labill. and S. vimineum Sm. Information on their morphology, distribution and conservation status in the state is discussed based primarily upon Tasmanian Herbarium (HO) records. The leaf morphology of both species is described