1,713 research outputs found
The effect of silicon on the glass forming ability of the Cu47Ti34Zr11Ni8 bulk metallic glass forming alloy during processing of composites
Composites of the Cu47Ti34Zr11Ni8 bulk metallic glass, reinforced with up to 30 vol % SiC particles are synthesized and characterized. Results based on x-ray diffraction, optical microscopy, scanning Auger microscopy, and differential scanning calorimetry (DSC) are presented. During processing of the composites, a TiC layer forms around the SiC particles and Si diffuses into the Cu47Ti34Zr11Ni8 matrix stabilizing the supercooled liquid against crystallization. The small Si addition between 0.5 and 1 at. % increases the attainable maximum thickness of glassy ingots from 4 mm for Cu–Ti–Zr–Ni alloys to 7 mm for Cu–Ti–Zr–Ni–Si alloys. DSC analyses show that neither the thermodynamics nor the kinetics of the alloy are affected significantly by the Si addition. This suggests that Si enhances the glass forming ability by chemically passivating impurities such as oxygen and carbon that cause heterogeneous nucleation in the melt
Mechanical properties of Zr_(57)Nb_5Al_(10)Cu_(15.4)Ni_(12.6) metallic glass matrix particulate composites
To increase the toughness of a metallic glass with the nominal composition Zr_(57)Nb_5Al_(10)Cu_(15.4)Ni_(12.6), it was used as the matrix in particulate composites reinforced with W, WC, Ta, and SiC. The composites were tested in compression and tension experiments. Compressive strain to failure increased by more than 300% compared with the unreinforced Zr_(57)Nb_5Al_(10)Cu_(15.4)Ni_(12.6), and energy to break of the tensile samples increased by more than 50%. The increase in toughness came from the particles restricting shear band propagation, promoting the generation of multiple shear bands and additional fracture surface area. There was direct evidence of viscous flow of the metallic glass matrix within the confines of the shear bands
Processing of carbon-fiber-reinforced Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 bulk metallic glass composites
Carbon-fiber-reinforced bulk metallic glass composites are produced by infiltrating liquid Zr41.2Ti13.8Cu12.5Ni10.0Be22.5 into carbon fiber bundles with diameter of the individual fiber of 5 mum. Reactive wetting occurs by the formation of a ZrC layer around the fibers. This results in a composite with a homogeneous fiber distribution. The volume fraction of the fibers is about 50% and the density of the composite amounts to 4.0 g/cm(^3)
Editorial: Manipulation of gut microbiota as a key target to intervene on the onset and progression of digestive system diseases
Editorial on the Research Topic
Manipulation of gut microbiota as a key target to intervene on the
onset and progression of digestive system disease
Elevation of ventricular defibrillation threshold in dogs by antiarrhythmic drugs
Effects of antiarrhythmic drugs upon the threshold delivered energy (TDE) and threshold peak current (TPC) for electrical ventricular defibrillation by damped sinusoidal shocks were investigated in 25 pentobarbital-anesthetized dogs. TDE and TPC were increased by the three antiarrhythmic drugs tested. Bolus injections produced a transient rise, and continuous infusions produced a steady rise in defibrillation threshold. The maximal percent elevations in mean defibrillation threshold during the 60 minutes after intravenous drug treatment in groups of n = 5 dogs were: Treatment % increase in TDE % increase in TPC Lidocaine bolus (3 mg/kg) 48 26 Lidocaine (0.5 mg/Kg/min) 99 45 Quinidine bolus (50 mg/Kg) 172 70 Diphenylhydantoin (1 mg/Kg/min) 83 35 Controls 1 4 Accordingly, individuals receiving antiarrhythmic drugs whose hearts nonetheless fibrillate may require greater electric shock strength for defibrillation
Dielectric properties of condensed systems composed of fragments
The dielectric properties of molecules or nanostructures are usually modified
in a complex manner, when assembled into a condensed phase. We propose a
first-principles method to compute polarizabilities of sub-entities of solids
and liquids, which accounts for multipolar interactions at all orders, and is
applicable to any semiconductor or insulator. The method only requires the
evaluation of induced fields in the condensed phase, with no need of multiple
calculations for each constituent. As an example, we present results for the
molecular polarizabilities of water in a wide pressure and temperature range.
We found that at ambient conditions, the dipole-induced-dipole approximation is
sufficiently accurate and the Clausius-Mossotti relation may be used, e.g. to
obtain molecular polarizabilities from experimental refractive indexes. However
with increasing pressure this approximation becomes unreliable and in the case
of ice X the Clausius-Mossotti relation is not valid.Comment: 16 pages, 4 figures, 1 tabl
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Treatability study on the use of by-product sulfur in Kazakhstan for the stabilization of hazardous and radioactive wastes
The Republic of Kazakhstan generates significant quantities of excess sulfur from the production and refining of petroleum reserves. In addition, the country also produces hazardous, and radioactive wastes which require treatment/stabilization. In an effort to find secondary uses for the elemental sulfur, and simultaneously produce a material which could be used to encapsulate, and reduce the dispersion of harmful contaminants into the environment, BNL evaluated the use of the sulfur polymer cement (SPC) produced from by-product sulfur in Kazakhstan. This thermoplastic binder material forms a durable waste form with low leaching properties and is compatible with a wide range of waste types. Several hundred kilograms of Kazakhstan sulfur were shipped to the U.S. and converted to SPC (by reaction with 5 wt% organic modifiers) for use in this study. A phosphogypsum sand waste generated in Kazakhstan during the purification of phosphate fertilizer was selected for treatment. Waste loading of 40 wt% were easily achieved. Waste form performance testing included compressive strength, water immersion, and Accelerated Leach Testing. 14 refs., 7 figs., 6 tabs
A targeted gene panel that covers coding, non-coding and short tandem repeat regions improves the diagnosis of patients with neurodegenerative diseases
Genetic testing for neurodegenerative diseases (NDs) is highly challenging because of genetic heterogeneity and overlapping manifestations. Targeted-gene panels (TGPs), coupled with next-generation sequencing (NGS), can facilitate the profiling of a large repertoire of ND-related genes. Due to the technical limitations inherent in NGS and TGPs, short tandem repeat (STR) variations are often ignored. However, STR expansions are known to cause such NDs as Huntington\u27s disease and spinocerebellar ataxias type 3 (SCA3). Here, we studied the clinical utility of a custom-made TGP that targets 199 NDs and 311 ND-associated genes on 118 undiagnosed patients. At least one known or likely pathogenic variation was found in 54 patients; 27 patients demonstrated clinical profiles that matched the variants; and 16 patients whose original diagnosis were refined. A high concordance of variant calling were observed when comparing the results from TGP and whole-exome sequencing of four patients. Our in-house STR detection algorithm has reached a specificity of 0.88 and a sensitivity of 0.82 in our SCA3 cohort. This study also uncovered a trove of novel and recurrent variants that may enrich the repertoire of ND-related genetic markers. We propose that a combined comprehensive TGPs-bioinformatics pipeline can improve the clinical diagnosis of NDs
Sporobolus stapfianus: Insights into desiccation tolerance in the resurrection grasses from linking transcriptomics to metabolomics
Predominant clusters of SDATs that share distinct patterns of abundance during dehydration: A. Predominant patterns of abundance for transcripts in clusters that exhibited increased abundance during dehydration. B. Predominant patterns of abundance for transcripts in clusters that exhibited a decreased abundance during dehydration. (PDF 226 kb
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