25 research outputs found
Modifiable risk factors associated with bone deficits in childhood cancer survivors
<p>Abstract</p> <p>Background</p> <p>To determine the prevalence and severity of bone deficits in a cohort of childhood cancer survivors (CCS) compared to a healthy sibling control group, and the modifiable factors associated with bone deficits in CCS.</p> <p>Methods</p> <p>Cross-sectional study of bone health in 319 CCS and 208 healthy sibling controls. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry (DXA). Generalized estimating equations were used to compare measures between CCS and controls. Among CCS, multivariable logistic regression was used to evaluate odds ratios for BMD Z-score ≤ -1.</p> <p>Results</p> <p>All subjects were younger than 18 years of age. Average time since treatment was 10.1 years (range 4.3 - 17.8 years). CCS were 3.3 times more likely to have whole body BMD Z-score ≤ -1 than controls (95% CI: 1.4-7.8; p = 0.007) and 1.7 times more likely to have lumbar spine BMD Z-score ≤ -1 than controls (95% CI: 1.0-2.7; p = 0.03). Among CCS, hypogonadism, lower lean body mass, higher daily television/computer screen time, lower physical activity, and higher inflammatory marker IL-6, increased the odds of having a BMD Z-score ≤ -1.</p> <p>Conclusions</p> <p>CCS, less than 18 years of age, have bone deficits compared to a healthy control group. Sedentary lifestyle and inflammation may play a role in bone deficits in CCS. Counseling CCS and their caretakers on decreasing television/computer screen time and increasing activity may improve bone health.</p
Evaluation of an Immunoradiometric Assay for Bone Alkaline Phosphatase Mass Concentration in Human Sera
Peer Reviewe
An Immunoblotting Procedure Following Agarose Gel Electrophoresis for Subclass Typing of IgG Paraproteins in Human Sera
Peer Reviewe
Zur analytischen und diagnostischen Validität biochemischer Marker des Knochenstoffwechsels
Zur analytischen und diagnostischen Validität biochemischer Marker des Knochenstoffwechsels
Concentration of the Cross-Linked Carboxyterminal Telopeptide of type I Collagen in Serum of Young Growing Rats Fed a Low Calcium and Vitamin D-Deficient Diet
Optimisation of a New Continuous UV Assay for the Determination of Blood Coagulation Factor XIII Activity in Human Plasma
Peer Reviewe