Two-Thirds of Smear-Positive Tuberculosis Cases in the Community Were Undiagnosed in Northwest Ethiopia: Population Based Cross-Sectional Study

Background: Tuberculosis (TB) case detection rate remains low in Ethiopia. One of the underlying reasons is the emphasis on passive case finding strategy which may seriously underestimate the burden of the disease. Estimating the prevalence of smear-positive pulmonary TB through active case finding at population level can help assessing the degree to which passive case detection is successful. Methods and findings: This is population based cross-sectional study. The study population was all individuals aged $14 years. Interviews using a uniform questionnaire were done initially to identify individuals with chronic cough ($15 days) and the two sputum (spot and morning) samples were gathered for standard smear microscopy. A total of 23,590 individuals aged $14 years were interviewed and 984 had a chronic cough for$15 days. Of 831 individuals who provided two sputum samples for acid fast bacilli (AFB), 41 had positive smears. A total of 22 smear-positive TB cases detected through passive case finding were on anti-TB treatment. The prevalence of new smear-positive TB was 174 per 100,000 in persons aged $14 years (95$45 years [AOR: 2.26, 95 % CI (1.12–4.59). Conclusions: The study revealed that about two-thirds of patients with active TB remain undiagnosed and thus untreated. This may indicate the need for strengthening case detection at the community level. Furthermore, the high burden of T

Comapison of carcass characteristics of Boran and Arsi-Bale goats under different durations of feedlot management

The objective of this study was to assess the carcass characteristics of two goat breed types under different durations of feedlot management. Forty eight yearling intact male Borana (n=24) and Arsi-Bale (n=24) goats were used in a 2 x 3 factorial arrangement, the factors being breed-type (Borana and Arsi-bale) and feeding days (90, 120 and 150). The goats were slaughtered after 18 hours fasting to evaluate the various carcass traits. The carcasses were separated into leg, lion, rack, shoulder and neck and breast and shank primal cuts. The Borana goats possessed heavier live weight, empty body weight, carcass weight and length than the Arsi-Bale goats in the feedlot environment. Dressing percentage varied from 41.0 to 45.9% for both goat breed types. Borana had greater rib eye area than Arsi-Bale goats for 120 (42.9±3.99) and 150 (47.3±1.28) feeding days. Back fat thickness was higher for both breed-types for 150 days feedlot feeding. The highest bone proportion was 30.9% for Arsi-Bale goats while the lowest was 25.7% for Borana goats. The percentage of rack fat of Borana was higher than for the Arsi-Bale goats

Molecular Structure of Poly(methyl methacrylate) Surface II: Effect of Stereoregularity Examined through All-Atom Molecular Dynamics

Utilizing all-atom molecular dynamics (MD), we have analyzed the effect of tacticity and temperature on the surface structure of poly(methyl methacrylate) (PMMA) at the polymer–vacuum interface. We quantify these effects primarily through orientation, measured as the tilt with respect to the surface normal, and the surface number densities of the α-methyl, ester-methyl, carbonyl, and backbone methylene groups. Molecular structure on the surface is a complex interplay between orientation and number densities and is challenging to capture through sum frequency generation (SFG) spectroscopy alone. Independent quantification of the number density and orientation of chemical groups through all-atom MD presents a comprehensive model of stereoregular PMMA on the surface. SFG analysis presented in part I of this joint publication measures the orientation of molecules that are in agreement with MD results. We observe the ester-methyl groups as preferentially oriented, irrespective of tacticity, followed by the α-methyl and carbonyl groups. SFG spectroscopy also points to ester-methyl being dominant on the surface. The backbone methylene groups show a very broad angular distribution, centered along the surface plane. The surface number density ratios of ester-methyl to α-methyl groups show syndiotactic PMMA having the lowest value. Isotactic PMMA has the highest ratios of ester- to α-methyl. These subtle trends in the relative angular orientation and number densities that influence the variation of surface structure with tacticity are highlighted in this article. A more planar conformation of the syndiotactic PMMA along the surface (x–y plane) can be visualized through the trajectories from all-atom MD. Results from conformation tensor calculations for chains with any of their segments contributing to the surface validate the visual observation