Carotid intima media thickness and low high-density lipoprotein (HDL) in South Asian immigrants: could dysfunctional HDL be the missing link?

IntroductionSouth Asian immigrants (SAIs) in the US exhibit higher prevalence of coronary artery disease (CAD) and its risk factors compared with other ethnic populations. Conventional CAD risk factors do not explain the excess CAD risk; therefore there is a need to identify other markers that can predict future risk of CAD in high-risk SAIs. The objective of the current study is to assess the presence of sub-clinical CAD using common carotid artery intima-media thickness (CCA-IMT), and its association with metabolic syndrome (MS) and pro-inflammatory/dysfunctional HDL (Dys-HDL).Material and methodsA community-based study was conducted on 130 first generation SAIs aged 35-65 years. Dys-HDL was determined using the HDL inflammatory index. Analysis was completed using logistic regression and Fisher's exact test.ResultsSub-clinical CAD using CCA-IMT ≥ 0.8 mm (as a surrogate marker) was seen in 31.46%. Age and gender adjusted CCA-IMT was significantly associated with type 2 diabetes (p = 0.008), hypertension (p = 0.012), high-sensitivity C-reactive protein (p < 0.001) and homocysteine (p = 0.051). Both the presence of MS and Dys-HDL was significantly correlated with CCA-IMT, even after age and gender adjustment. The odds of having Dys-HDL with CCA-IMT were 5 times (95% CI: 1.68, 10.78).ConclusionsThere is a need to explore and understand non-traditional CAD risk factors with a special focus on Dys-HDL, knowing that SAIs have low HDL levels. This information will not only help to stratify high-risk asymptomatic SAI groups, but will also be useful from a disease management point of view

Steady-State Analysis of Load Balancing with Coxian-22 Distributed Service Times

This paper studies load balancing for many-server ($N$ servers) systems. Each server has a buffer of size $b-1,$ and can have at most one job in service and $b-1$ jobs in the buffer. The service time of a job follows the Coxian-2 distribution. We focus on steady-state performance of load balancing policies in the heavy traffic regime such that the normalized load of system is $\lambda = 1 - N^{-\alpha}$ for $0<\alpha<0.5.$ We identify a set of policies that achieve asymptotic zero waiting. The set of policies include several classical policies such as join-the-shortest-queue (JSQ), join-the-idle-queue (JIQ), idle-one-first (I1F) and power-of-$d$-choices (Po$d$) with $d=O(N^\alpha\log N)$. The proof of the main result is based on Stein's method and state space collapse. A key technical contribution of this paper is the iterative state space collapse approach that leads to a simple generator approximation when applying Stein's method

Ozone predictabilities due to meteorological uncertainties in the Mexico City basin using ensemble forecasts

The purpose of the present study is to investigate the sensitivity of ozone (O&lt;sub&gt;3&lt;/sub&gt;) predictions in the Mexico City Metropolitan Area (MCMA) to meteorological initial uncertainties and planetary boundary layer (PBL) parameterization schemes using state-of-the-art meteorological and photochemical prediction models through ensemble forecasts. The simulated periods (3, 9, 15 and 29 March 2006) represent four typical meteorological episodes ("South-Venting", "O&lt;sub&gt;3&lt;/sub&gt;-North", "O&lt;sub&gt;3&lt;/sub&gt;-South" and "Convection-North", respectively) in the Mexico City basin during the MCMA-2006/MILAGRO campaign. Our results demonstrate that the uncertainties in meteorological initial conditions have significant impacts on O&lt;sub&gt;3&lt;/sub&gt; predictions, including peak time O&lt;sub&gt;3&lt;/sub&gt; concentrations ([O&lt;sub&gt;3&lt;/sub&gt;]), horizontal and vertical O&lt;sub&gt;3&lt;/sub&gt; distributions, and temporal variations. The ensemble spread of the simulated peak [O&lt;sub&gt;3&lt;/sub&gt;] averaged over the city's ambient monitoring sites can reach up to 10 ppb. The increasing uncertainties in meteorological fields during peak O&lt;sub&gt;3&lt;/sub&gt; period contribute to the largest unpredictability in O&lt;sub&gt;3&lt;/sub&gt; simulations, while the impacts of wind speeds and PBL height on [O&lt;sub&gt;3&lt;/sub&gt;] are more straightforward and important. The magnitude of the ensemble spreads varies with different PBL schemes and meteorological episodes. The uncertainties in O&lt;sub&gt;3&lt;/sub&gt; predictions caused by PBL schemes mainly come from their ability to represent the mixing layer height; but overall, these uncertainties are smaller than those from the uncertainties in meteorological initial conditions

Vertical distributions of non-methane hydrocarbons and halocarbons in the lower troposphere over northeast China

Vertical distributions of air pollutants are crucial for understanding the key processes of atmospheric transport and for evaluating chemical transport models. In this paper, we present measurements of non-methane hydrocarbons (NMHCs) and halocarbons obtained from an intensive aircraft study over northeast (NE) China in summer 2007. Most compounds exhibited a typical negative profile of decreasing mixing ratios with increasing altitude, although the gradients differed with different species. Three regional plumes with enhanced VOC mixing ratios were discerned and characterized. An aged plume transported from the northern part of the densely populated North China Plain (NCP; i.e. Beijing-Tianjin area) showed relatively higher levels of HCFC-22, 1,2-dichloroethane (1,2-DCE) and toluene. In comparison, the plume originating from Korea had higher abundances of CFC-12, tetrachloroethene (C2Cl4) and methyl chloride (CH3Cl), while regional air masses from NE China contained more abundant light alkanes. By comparing these results with the earlier PEM-West B (1994) and TRACE-P (2001) aircraft measurements, continuing declining trends were derived for methyl chloroform (CH3CCl3), tetrachloromethane (CCl4) and C2Cl4 over the greater China-northwestern Pacific region, indicating the accomplishment of China in reducing these compounds under the Montreal protocol. However, the study also provided evidence for the continuing emissions of several halocarbons in China in 2007, such as CFCs (mainly from materials in stock) and HCFCs. © 2011 Elsevier Ltd

Dynamical chiral symmetry breaking and a critical mass

On a bounded, measurable domain of non-negative current-quark mass, realistic models of QCD's gap equation can simultaneously admit two inequivalent dynamical chiral symmetry breaking (DCSB) solutions and a solution that is unambiguously connected with the realisation of chiral symmetry in the Wigner mode. The Wigner solution and one of the DCSB solutions are destabilised by a current-quark mass and both disappear when that mass exceeds a critical value. This critical value also bounds the domain on which the surviving DCSB solution possesses a chiral expansion. This value can therefore be viewed as an upper bound on the domain within which a perturbative expansion in the current-quark mass around the chiral limit is uniformly valid for physical quantities. For a pseudoscalar meson constituted of equal mass current-quarks, it corresponds to a mass m_{0^-}~0.45GeV. In our discussion we employ properties of the two DCSB solutions of the gap equation that enable a valid definition of in the presence of a nonzero current-mass. The behaviour of this condensate indicates that the essentially dynamical component of chiral symmetry breaking decreases with increasing current-quark mass.Comment: 9 pages, 7 figures. Minor wording change

Soliton with a Pion Field in the Global Color Symmetry Model

We calculate the property of the global color symmetry model soliton with the pion field being included explicitly. The calculated results indicate that the pion field provides a strong attraction so that the eigen-energy of a quark and the mass of a soliton reduce drastically, in contrast to those with only the sigma field.Comment: 15 pages, 2 figure

New Method for Numerically Solving the Chemical Potential Dependence of the Dressed Quark Propagator

Based on the rainbow approximation of Dyson-Schwinger equation and the assumption that the inverse dressed quark propagator at finite chemical potential is analytic in the neighborhood of $\mu=0$, a new method for obtaining the dressed quark propagator at finite chemical potential $\mu$ from the one at zero chemical potential is developed. Using this method the dressed quark propagator at finite chemical potential can be obtained directly from the one at zero chemical potential without the necessity of numerically solving the corresponding coupled integral equations by iteration methods. A comparison with previous results is given.Comment: Revtex, 14 pages, 5 figure

Dielectric Behavior of Nonspherical Cell Suspensions

Recent experiments revealed that the dielectric dispersion spectrum of fission yeast cells in a suspension was mainly composed of two sub-dispersions. The low-frequency sub-dispersion depended on the cell length, whereas the high-frequency one was independent of it. The cell shape effect was qualitatively simulated by an ellipsoidal cell model. However, the comparison between theory and experiment was far from being satisfactory. In an attempt to close up the gap between theory and experiment, we considered the more realistic cells of spherocylinders, i.e., circular cylinders with two hemispherical caps at both ends. We have formulated a Green function formalism for calculating the spectral representation of cells of finite length. The Green function can be reduced because of the azimuthal symmetry of the cell. This simplification enables us to calculate the dispersion spectrum and hence access the effect of cell structure on the dielectric behavior of cell suspensions.Comment: Preliminary results have been reported in the 2001 March Meeting of the American Physical Society. Accepted for publications in J. Phys.: Condens. Matte

A climatology of the F-layer equivalent winds derived from ionosonde measurements over two decades along the 120°-150°E sector

International audienceThe vertical equivalent winds (VEWs) at the F-layer are analyzed along the 120°-150°E longitude sector with an emphasis on their latitudinal dependence. The VEWs are derived from the monthly median data of fourteen ionosonde stations over two decades. The results show that the VEWs have considerable dependences on the magnetic latitude with an approximate symmetry about the magnetic equator. They are mostly controlled by the electric field drifts in the magnetic equatorial region, and shift to be mostly contributed by neutral winds at mid-latitudes. The relative contribution of the two dynamic factors is regulated by the magnetic dip in addition to their own magnitudes. The VEWs generally have opposite directions and different magnitudes between lower and higher latitudes. At solar minimum, the magnitudes of VEWs are only between -20 and 20m/s at lower latitudes, while at higher latitudes they tend to increase with latitudes, typically having magnitudes between 20-40m/s. At solar maximum, the VEWs are reduced by about 10-20m/s in magnitudes during some local times at higher latitudes. A tidal analysis reveals that the relative importance of major tidal components is also different between lower and higher latitudes. The VEWs also depend on local time, season and solar activity. At higher latitudes, the nighttime VEWs have larger magnitude during post-midnight hours and so do the daytime ones before midday. The VEWs tend to have an inverse relationship with solar activity not only at night, but also by day, which is different from the meridional winds predicted by the HWM93 model. The latitudinal dependence of VEWs has two prevailing trends: one is a maximum at the highest latitudes (as far as the latitudes concerned in the present work); the other is a mid-latitude maximum. These two latitudinal trends are mostly dependent on season, while they depend relatively weakly on local time and solar activity. The latitudinal gradients of VEWs also show a tendency of a mid-latitude maximum, except that there are much stronger latitudinal gradients at southern higher mid-latitudes in some seasons. The gradients during daytime are much smaller at solar maximum than minimum, whereas they are generally comparable at night under both solar activity levels