Ein Web-basierter Computergraphik-Kurs im Baukastensystem

Aus der Zusammenfassung: 'Dieses Beispiel eines interaktiven Online-Kurses zeigt, wie virtuelle Experimente die traditionellen Lehrmethoden im Bereich der Computergraphik sinnvoll ergänzen. Das Zusammenspiel von Java und dem World-Wide-Web erlaubt die einheitliche Integration von hypertextuellen Vorlesungstexten, interaktiven Visualisierungen, virtuellen Experimenten, Programmierübungen und Programmierschnittstellen in eine unbeschränkt nutzbare virtuelle Lernumgebung

Improved homology-driven computational validation of protein-protein interactions motivated by the evolutionary gene duplication and divergence hypothesis

<p>Abstract</p> <p>Background</p> <p>Protein-protein interaction (PPI) data sets generated by high-throughput experiments are contaminated by large numbers of erroneous PPIs. Therefore, computational methods for PPI validation are necessary to improve the quality of such data sets. Against the background of the theory that most extant PPIs arose as a consequence of gene duplication, the sensitive search for homologous PPIs, i.e. for PPIs descending from a common ancestral PPI, should be a successful strategy for PPI validation.</p> <p>Results</p> <p>To validate an experimentally observed PPI, we combine FASTA and PSI-BLAST to perform a sensitive sequence-based search for pairs of interacting homologous proteins within a large, integrated PPI database. A novel scoring scheme that incorporates both quality and quantity of all observed matches allows us (1) to consider also tentative paralogs and orthologs in this analysis and (2) to combine search results from more than one homology detection method. ROC curves illustrate the high efficacy of this approach and its improvement over other homology-based validation methods.</p> <p>Conclusion</p> <p>New PPIs are primarily derived from preexisting PPIs and not invented <it>de novo</it>. Thus, the hallmark of true PPIs is the existence of homologous PPIs. The sensitive search for homologous PPIs within a large body of known PPIs is an efficient strategy to separate biologically relevant PPIs from the many spurious PPIs reported by high-throughput experiments.</p

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes

Theory and Practice of Geometric Modeling

This book originates from the lectures given at the international conference “Theory and Practice of Geometric Modelling”, Blaubeuren, FRG, October 3-7, 1988, that brought together leading experts from universities, system developers, and system users, to discuss new concepts and future trends in geometric modelling. The book covers a variety of topics on an advanced level and is organized as follows. Part A contains new algorithms and techniques for modelling objects that are bounded by free form surfaces. Part B focuses on surface/surface intersections, new types of blending surfaces and speed ups for ray tracing. Part C contains some new geometric tools. Part D discusses different representation schemes in solid modelling, conversions between these different schemes, and some applications. Part E covers some issues of product modelling, automatic tolerancing, high level specification of solid models (constraints, features) and the need for better user interfaces

A Real-Time Sound Rendering Algorithm for Complex Scenes

We present a novel output-sensitive algorithm for sound rendering of complex scenes, i.e. scenes that contain a large amount of sound sources

10th Annual Report 1996 Interactive Graphics Systems Lab (WSI/GRIS)

s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3.3 Recommendation for course combinations . . . . . . . . . . . . . . . . 10 4 Research Activities 11 4.1 Scientific Visualization . . . . . . . . . . . . . . . . . . . . . . . . . . 11 4.2 Particle Systems and Physical Based Modeling . . . . . . . . . . . . . 15 4.3 Modeling and Visualization of Clothes . . . . . . . . . . . . . . . . . 17 4.4 Global Illumination Techniques . . . . . . . . . . . . . . . . . . . . . 19 4.5 Terrain-Modelling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 4.6 Triangulation, Meshgeneration and Meshreduction . . . . . . . . . . 26 4.7 Web-based Graphics Education . . . . . . . . . . . . . . . . . . . . . 31 4.8 Modeling and finite element analysis of the human mandible . . . . . 35 4.9 MEDStation: A PACS Workstation with Integrated CASE tool . . . 38 4.10 Projects and integrated applications of the MEDStation: . . . . . . . 44 4.11 Adaptivity in Direct-Manipulative Graphical Use..

Generation of Multiresolution Models from CAD - Data for Real Time Rendering

. A mesh refinement and a mesh simplification algorithm are presented. Both algorithms guarantee a user-defined error tolerance and deliver a multiresolution model. After the computation of the multiresolution model triangulation of the surface patches at variable resolutions can be incrementally generated on-the-fly at rendering time. The resulting triangulations form hierarchical Delaunay triangulations in parameter space. 1 Introduction and Previous work The visualization of large CAD-models, like cars, trains, aero planes, etc. becomes a major challenge in the context of virtual reality. In most experiments a number of such models have to be visualized and animated simultaneously. Examples are the optimization of the cabin of a train or the optimization of a driver&apos;s position in a car. To examine the panorama in such a place, not only the train or car themselves have to be visualized but also other cars, pedestrians, buildings, etc. Despite the performance of modern graphics hardw..

Real-Time Caustics

We present a new algorithm to render caustics. The algorithm discretizes the specular surfaces into sample points. Each of the sample points is treated as a pinhole camera that projects an image of the incoming light onto the diffuse receiver surfaces. Anti-aliasing is performed by considering the local surface curvature at the sample points to filter the projected images. The algorithm can be implemented using programmable texture mapping hardware. It allows to render caustics in fully dynamic scenes in real-time on current PC hardware