The Abbey of the Dunes (Koksijde) and Noordduinen: the environmental link restored

The Abbey of the Dunes (Ten Duinen) at Koksijde, founded in the 12th century and abandoned around 1600, forms the subject of a land use planning project realized by the Flemish Land Agency (Vlaamse Landmaatschappij). Initially the project focussed on the museum and the integration of the abbey ruins in an open-air museum. However the site presented an opportunity to involve the Noordduinen, bordering on the abbey park, in a nature restoration project. The key intention was to restore the landscape connection between the abbey and the dunes, as it was in the Middle Ages. The proposed actions consist of breaking up a road, deviation of the traffic, upgrading the abbey park and start of a nature restoration project in the Noordduinen. The main bottlenecks were deviation of the traffic, excavation and preservation of archaeological finds and intensive recreational use of the Noordduinen. Continuous consultation and deliberation with all involved authorities and with the local inhabitants of Koksijde resulted in a plan supported by the majority of the community

A perturbative analysis of tachyon condensation

Tachyon condensation in the open bosonic string is analyzed using a perturbative expansion of the tachyon potential around the unstable D25-brane vacuum. Using the leading terms in the tachyon potential, Pad\'e approximants can apparently give the energy of the stable vacuum to arbitrarily good accuracy. Level-truncation approximations up to level 10 for the coefficients in the tachyon potential are extrapolated to higher levels and used to find approximants for the full potential. At level 14 and above, the resulting approximants give an energy less than -1 in units of the D25-brane tension, in agreement with recent level-truncation results by Gaiotto and Rastelli. The extrapolated energy continues to decrease below -1 until reaching a minimum near level 26, after which the energy turns around and begins to approach -1 from below. Within the accuracy of this method, these results are completely consistent with an energy which approaches -1 as the level of truncation is taken to be arbitrarily large.Comment: 8 pages, 3 eps figures, Latex; v2: typo correcte

Organic layers on silicon result in a unique hybrid fet

A Field-Effect Transistor (FET) is presented that combines the conventional lay-out of the silicon substrate (channel and source and drain connections) with a Si-C linked organic gate insulator contacted via an organic, conducting polymer. It is shown that this hybrid device combines the excellent electrical behavior of the silicon substrate and the ease of use and good properties of organic insulators and contacting materials.\ud Keywords: organic monolayer, FET, conducting polyme

MarkerMiner 1.0: a new application for phylogenetic marker development using angiosperm transcriptomes

Premise of the study: Targeted sequencing using next-generation sequencing (NGS) platforms offers enormous potential for plant systematics by enabling economical acquisition of multilocus data sets that can resolve difficult phylogenetic problems. However, because discovery of single-copy nuclear (SCN) loci from NGS data requires both bioinformatics skills and access to high-performance computing resources, the application of NGS data has been limited. Methods and Results: We developed MarkerMiner 1.0, a fully automated, open-access bioinformatic workflow and application for discovery of SCN loci in angiosperms. Our new tool identified as many as 1993 SCN loci from transcriptomic data sampled as part of four independent test cases representing marker development projects at different phylogenetic scales. Conclusions: MarkerMiner is an easy-to-use and effective tool for discovery of putative SCN loci. It can be run locally or via the Web, and its tabular and alignment outputs facilitate efficient downstream assessments of phylogenetic utility, locus selection, intron-exon boundary prediction, and primer or probe development

Calcium puffs are generic InsP₃-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses

Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling. We characterized Ca2+ puffs in six cell types that expressed differing ratios of the three inositol 1,4,5-trisphosphate receptor isoforms. The amplitudes, spatial spreads and kinetics of the events were similar in each of the cell types. The resemblance of Ca2+ puffs in these cell types suggests that they are a generic elementary Ca2+ signal and, furthermore, that the different inositol 1,4,5-trisphosphate isoforms are functionally redundant at the level of subcellular Ca2+ signalling. Hormonal stimulation of SH-SY5Y neuroblastoma cells and HeLa cells for several hours downregulated inositol 1,4,5-trisphosphate expression and concomitantly altered the properties of the Ca2+ puffs. The amplitude and duration of Ca2+ puffs were substantially reduced. In addition, the number of Ca2+ puff sites active during the onset of a Ca2+ wave declined. The consequence of the changes in Ca2+ puff properties was that cells displayed a lower propensity to trigger regenerative Ca2+ waves. Therefore, Ca2+ puffs underlie inositol 1,4,5-trisphosphate signalling in diverse cell types and are focal points for regulation of cellular responses

O3/O7 Orientifold Truncations and Very Special Quaternionic-Kaehler Geometry

We study the orientifold truncation that arises when compactifying type II string theory on Calabi-Yau orientifolds with O3/O7-planes, in the context of supergravity. We look at the N=2 to N=1 reduction of the hypermultiplet sector of N=2 supergravity under the truncation, for the case of very special quaternionic-Kaehler target space geometry. We explicitly verify the Kaehler structure of the truncated spaces, and we study the truncated isometry algebra. For symmetric special quaternionic spaces, we give a complete overview of the spaces one finds after truncation. We also find new examples of dual Kaehler spaces, that give rise to flat potentials in N=1 supergravity.Comment: 25 pages, LaTeX, v2:curvature tensor of the dual symmetric spaces calculated, section 7 expanded, references added, v3:few typos fixed, version to appear in Class.Quantum Gravit

Heritability estimates of the novel trait 'suppressed in ovo virus infection' in honey bees (Apis mellifera)

Honey bees are under pressure due to abnormal high colony death rates, especially during the winter. The infestation by the Varroa destructor mite and the viruses that this ectoparasite transmits are generally considered as the bees' most important biological threats. Almost all efforts to remedy this dual infection have so far focused on the control of the Varroa mite alone and not on the viruses it transmits. In the present study, the sanitary control of breeding queens was conducted on eggs taken from drone brood for 4 consecutive years (2015-2018). The screening was performed on the sideline of an ongoing breeding program, which allowed us to estimate the heritabilities of the virus status of the eggs. We used the term 'suppressed in ovo virus infection' (SOV) for this novel trait and found moderate heritabilities for the presence of several viruses simultaneously and for the presence of single viral species. Colonies that expressed the SOV trait seemed to be more resilient to virus infections as a whole with fewer and less severe Deformed wing virus infections in most developmental stages, especially in the male caste. The implementation of this novel trait into breeding programs is recommended

Multilinear Wavelets: A Statistical Shape Space for Human Faces

We present a statistical model for $3$D human faces in varying expression, which decomposes the surface of the face using a wavelet transform, and learns many localized, decorrelated multilinear models on the resulting coefficients. Using this model we are able to reconstruct faces from noisy and occluded $3$D face scans, and facial motion sequences. Accurate reconstruction of face shape is important for applications such as tele-presence and gaming. The localized and multi-scale nature of our model allows for recovery of fine-scale detail while retaining robustness to severe noise and occlusion, and is computationally efficient and scalable. We validate these properties experimentally on challenging data in the form of static scans and motion sequences. We show that in comparison to a global multilinear model, our model better preserves fine detail and is computationally faster, while in comparison to a localized PCA model, our model better handles variation in expression, is faster, and allows us to fix identity parameters for a given subject.Comment: 10 pages, 7 figures; accepted to ECCV 201

A machine learning pipeline for discriminant pathways identification

Motivation: Identifying the molecular pathways more prone to disruption during a pathological process is a key task in network medicine and, more in general, in systems biology. Results: In this work we propose a pipeline that couples a machine learning solution for molecular profiling with a recent network comparison method. The pipeline can identify changes occurring between specific sub-modules of networks built in a case-control biomarker study, discriminating key groups of genes whose interactions are modified by an underlying condition. The proposal is independent from the classification algorithm used. Three applications on genomewide data are presented regarding children susceptibility to air pollution and two neurodegenerative diseases: Parkinson's and Alzheimer's. Availability: Details about the software used for the experiments discussed in this paper are provided in the Appendix