3,153 research outputs found

    Manufacturing bricks with fly ash and advanced coal combustion by-products

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    U.S. Department of Energy, National Energy Technology Laboratory, Cooperative Agreement No. DE FC26 998FT40028 with the West Virginia University Research Corporation-Combustion By-products Recycling Consortium.Ope

    Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes

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    Infection of human peripheral blood cells by SARS-CoV-2 has been debated because immune cells lack mRNA expression of both angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease type 2 (TMPRSS2). Herein we demonstrate that resting primary monocytes harbor abundant cytoplasmic ACE2 and TMPRSS2 protein and that circulating exosomes contain significant ACE2 protein. Upon ex vivo TLR4/7/8 stimulation, cytoplasmic ACE2 was quickly translocated to the monocyte cell surface independently of ACE2 transcription, while TMPRSS2 surface translocation occurred in conjunction with elevated mRNA expression. The rapid translocation of ACE2 to the monocyte cell surface was blocked by the endosomal trafficking inhibitor endosidin 2, suggesting that endosomal ACE2 could be derived from circulating ACE2-containing exosomes. TLR-stimulated monocytes concurrently expressing ACE2 and TMPRSS2 on the cell surface were efficiently infected by SARS-CoV-2, which was significantly mitigated by remdesivir, TMPRSS2 inhibitor camostat, and anti-ACE2 antibody. Mass cytometry showed that ACE2 surface translocation in peripheral myeloid cells from patients with severe COVID-19 correlated with its hyperactivation and PD-L1 expression. Collectively, TLR4/7/8-induced ACE2 translocation with TMPRSS2 expression makes circulating monocytes permissive to SARS-CoV-2 infection

    Measurements of the Cross Section for e+e- -> hadrons at Center-of-Mass Energies from 2 to 5 GeV

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    We report values of R=σ(e+ehadrons)/σ(e+eμ+μ)R = \sigma(e^+e^-\to {hadrons})/\sigma(e^+e^-\to\mu^+\mu^-) for 85 center-of-mass energies between 2 and 5 GeV measured with the upgraded Beijing Spectrometer at the Beijing Electron-Positron Collider.Comment: 5 pages, 3 figure

    Observation of a near-threshold enhancement in th p pbar mass spectrum from radiative J/psi-->gamma p pbar decays

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    We observe a narrow enhancement near 2mp in the invariant mass spectrum of ppbar pairs from radiative J/psi-->gamma ppbar decays. The enhancement can be fit with either an S- or P-wave Breit Wigner fuction. In the case of the S-wave fit, the peak mass is below the 2mp threshold and the full width is less than 30 MeV. These mass and width values are not consistent with the properties of any known meson resonance.Comment: 5 pages, 4 figures, submitted to Phys. Rev. Let

    \psi(2S) Decays into \J plus Two Photons

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    Using \gamma \gamma J/\psi, J/\psi \ra e^+ e^- and μ+μ\mu^+ \mu^- events from a sample of 14.0×10614.0\times 10^6 \psip decays collected with the BESII detector, the branching fractions for \psip\ra \pi^0\J, \eta\J, and \psi(2S)\ar\gamma\chi_{c1},\gamma\chi_{c2}\ar\gamma\gamma\jpsi are measured to be B(\psip\ra \pi^0\J) = (1.43\pm0.14\pm0.13)\times 10^{-3}, B(\psip\ra \eta\J) = (2.98\pm0.09\pm0.23)%, B(\psi(2S)\ar\gamma\chi_{c1}\ar\gamma\gamma\jpsi) = (2.81\pm0.05\pm 0.23)%, and B(\psi(2S)\ar\gamma\chi_{c2}\ar\gamma\gamma\jpsi) = (1.62\pm0.04\pm 0.12)%.Comment: 7 pages, 6 figures. submitted to Phys. Rev.

    First Measurement of the Branching Fraction of the Decay psi(2S) --> tau tau

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    The branching fraction of the psi(2S) decay into tau pair has been measured for the first time using the BES detector at the Beijing Electron-Positron Collider. The result is Bττ=(2.71±0.43±0.55)×103B_{\tau\tau}=(2.71\pm 0.43 \pm 0.55) \times 10^{-3}, where the first error is statistical and the second is systematic. This value, along with those for the branching fractions into e+e- and mu+mu of this resonance, satisfy well the relation predicted by the sequential lepton hypothesis. Combining all these values with the leptonic width of the resonance the total width of the psi(2S) is determined to be (252±37)(252 \pm 37) keV.Comment: 9 pages, 2 figure

    Measurements of ψ(2S)\psi(2S) decays into Vector- Tensor final states

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    Decays of the ψ(2S)\psi(2S) into vector plus tensor meson final states have been studied with 14 million ψ(2S)\psi(2S) events collected with the BESII detector. Branching fractions of \psi(2S) \rt \omega f_{2}(1270), ρa2(1320)\rho a_2(1320), K(892)0Kˉ2(1430)0+c.c.K^*(892)^0\bar{K}^*_2(1430)^0+c.c. and ϕf2(1525)\phi f_2^{\prime}(1525) are determined. They improve upon previous BESI results and confirm the violation of the "12%" rule for ψ(2S)\psi(2S) decays to VT channels with higher precision.Comment: 7 pages, 7 figures and 2 table
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