3,153 research outputs found
Manufacturing bricks with fly ash and advanced coal combustion by-products
U.S. Department of Energy, National Energy Technology Laboratory, Cooperative Agreement No. DE FC26 998FT40028 with the West Virginia University Research Corporation-Combustion By-products Recycling Consortium.Ope
Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes
Infection of human peripheral blood cells by SARS-CoV-2 has been debated because immune cells lack mRNA expression of both angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease type 2 (TMPRSS2). Herein we demonstrate that resting primary monocytes harbor abundant cytoplasmic ACE2 and TMPRSS2 protein and that circulating exosomes contain significant ACE2 protein. Upon ex vivo TLR4/7/8 stimulation, cytoplasmic ACE2 was quickly translocated to the monocyte cell surface independently of ACE2 transcription, while TMPRSS2 surface translocation occurred in conjunction with elevated mRNA expression. The rapid translocation of ACE2 to the monocyte cell surface was blocked by the endosomal trafficking inhibitor endosidin 2, suggesting that endosomal ACE2 could be derived from circulating ACE2-containing exosomes. TLR-stimulated monocytes concurrently expressing ACE2 and TMPRSS2 on the cell surface were efficiently infected by SARS-CoV-2, which was significantly mitigated by remdesivir, TMPRSS2 inhibitor camostat, and anti-ACE2 antibody. Mass cytometry showed that ACE2 surface translocation in peripheral myeloid cells from patients with severe COVID-19 correlated with its hyperactivation and PD-L1 expression. Collectively, TLR4/7/8-induced ACE2 translocation with TMPRSS2 expression makes circulating monocytes permissive to SARS-CoV-2 infection
Measurements of the Cross Section for e+e- -> hadrons at Center-of-Mass Energies from 2 to 5 GeV
We report values of for 85 center-of-mass energies between
2 and 5 GeV measured with the upgraded Beijing Spectrometer at the Beijing
Electron-Positron Collider.Comment: 5 pages, 3 figure
Observation of a near-threshold enhancement in th p pbar mass spectrum from radiative J/psi-->gamma p pbar decays
We observe a narrow enhancement near 2mp in the invariant mass spectrum of
ppbar pairs from radiative J/psi-->gamma ppbar decays. The enhancement can be
fit with either an S- or P-wave Breit Wigner fuction. In the case of the S-wave
fit, the peak mass is below the 2mp threshold and the full width is less than
30 MeV. These mass and width values are not consistent with the properties of
any known meson resonance.Comment: 5 pages, 4 figures, submitted to Phys. Rev. Let
\psi(2S) Decays into \J plus Two Photons
Using \gamma \gamma J/\psi, J/\psi \ra e^+ e^- and events
from a sample of \psip decays collected with the BESII
detector, the branching fractions for \psip\ra \pi^0\J, \eta\J, and
\psi(2S)\ar\gamma\chi_{c1},\gamma\chi_{c2}\ar\gamma\gamma\jpsi are measured
to be B(\psip\ra \pi^0\J) = (1.43\pm0.14\pm0.13)\times 10^{-3}, B(\psip\ra
\eta\J) = (2.98\pm0.09\pm0.23)%,
B(\psi(2S)\ar\gamma\chi_{c1}\ar\gamma\gamma\jpsi) = (2.81\pm0.05\pm 0.23)%,
and B(\psi(2S)\ar\gamma\chi_{c2}\ar\gamma\gamma\jpsi) = (1.62\pm0.04\pm
0.12)%.Comment: 7 pages, 6 figures. submitted to Phys. Rev.
First Measurement of the Branching Fraction of the Decay psi(2S) --> tau tau
The branching fraction of the psi(2S) decay into tau pair has been measured
for the first time using the BES detector at the Beijing Electron-Positron
Collider. The result is ,
where the first error is statistical and the second is systematic. This value,
along with those for the branching fractions into e+e- and mu+mu of this
resonance, satisfy well the relation predicted by the sequential lepton
hypothesis. Combining all these values with the leptonic width of the resonance
the total width of the psi(2S) is determined to be keV.Comment: 9 pages, 2 figure
Measurements of decays into Vector- Tensor final states
Decays of the into vector plus tensor meson final states have been
studied with 14 million events collected with the BESII detector.
Branching fractions of \psi(2S) \rt \omega f_{2}(1270), ,
and are
determined. They improve upon previous BESI results and confirm the violation
of the "12%" rule for decays to VT channels with higher precision.Comment: 7 pages, 7 figures and 2 table
Distribution of Organochlorine Pesticides in a Sediment Profile of the Pearl River Estuary
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