Performance Management in Local Government: The Application of System Dynamics to Promote Data Use

The purpose of this article is to demonstrate how system dynamics can be used to enrich performance management in local government, focusing specifically on how the development of conceptual and simulation system dynamic models can foster a shared view of the relevant system among stakeholders to overcome factors that limit data use. Responding to this purpose, we present a normative case study on how key drivers can be used to foster a shared view of the residential refuse collection system for supporting policy and process changes. A major finding from our research, however, is that performance management cannot overlook the broader forces of citizenship outcomes that impact the community

Teaching Public Administration Abroad through the Fulbright Specialist Program

The purpose of this article is to promote the benefits of the Fulbright Specialist Program—which was created in 2001 as a short-term complement to the Fulbright Scholar Program—and to encourage more public administration scholars to consider teaching abroad. After providing an overview of the Fulbright Specialist Program and the collaborative teaching approach we used for the preparation and delivery of instructional materials, it presents a number of lessons learned from the perspective of the Fulbright Specialist and the host institution for maximizing the experience of teaching abroad. This article also is dedicated to the work of Fulbright, which has pursued its mission to increase mutual understanding between the people of the United States and the people of other countries for 65 years.The purpose of this article is to promote the benefits of the Fulbright Specialist Program—which was created in 2001 as a short-term complement to the Fulbright Scholar Program—and to encourage more public administration scholars to consider teaching abroad. After providing an overview of the Fulbright Specialist Program and the collaborative teaching approach we used for the preparation and delivery of instructional materials, it presents a number of lessons learned from the perspective of the Fulbright Specialist and the host institution for maximizing the experience of teaching abroad. This article also is dedicated to the work of Fulbright, which has pursued its mission to increase mutual understanding between the people of the United States and the people of other countries for 65 years

Introduction to a Symposium on Broadening the Application of Performance Management

The Italian Academy of Management (Accademia Italiana di Economia Aziendale (AIDEA)), which was founded in Bologna during July 1813, is one of the oldest academic societies in the world. On the occasion of celebrating its bicentenary, the AIDEA held a conference in Lecce, Italy, during September 2013 for AIDEA members and international scholars to present their research within six major areas: Economia Aziendale, Ragioneria ed Economia Aziendale in Italia, Accounting, Management & Organization, Public Management, and Banking & Finance. The theme of the conference—The Firm’s Role in the Economy: Does a Growth-Oriented Business Model Exist?—was in response to the global crisis that has raised new questions and challenges that scholars are trying to resolve, including how academic and professional studies can provide strategies on helping firms and markets contribute to economic growth. In order to support the conference theme, the performance management track focused in part on how organizational and interinstitutional performance management within the context of public administration can support sustainable economic and community growth

RE-ENGINEERING ATLAS SYSTEMS WITH WATLAS

The ATLAS language is a legacy language that currently runs on OpenVMS systems. Here, we describe a Windows-based system for re-engineering existing ATLAS applications, transforming them into equivalent C# source code that can be compiled and executed on Windows. ATLAS is used for developing testing programs that interact with avionics systems connected to a test station. ATLAS utilizes automated test equipment to issue commands and interrogate results in response to direct stimulus and signals from the unit under test. Windows-based ATLAS, or WATLAS, is composed of a Rascal-based transpiler, a "pre" and "post" processor, the target environment framework, and a Windows-based CASS Station simulator to execute the transpiled target source code. The thesis also provides an overview of the legacy CASS station and the ATLAS language, motivation for development of WATLAS, and a review of some of the competing technologies in this information technology space. Finally, a working prototype with minimal functionality will demonstrate the viability of this approach

The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis

<p>Abstract</p> <p>Background</p> <p>The process of malignant transformation, progression and metastasis of melanoma is poorly understood. Gene expression profiling of human cancer has allowed for a unique insight into the genes that are involved in these processes. Thus, we have attempted to utilize this approach through the analysis of a series of primary, non-metastatic cutaneous tumors and metastatic melanoma samples.</p> <p>Methods</p> <p>We have utilized gene microarray analysis and a variety of molecular techniques to compare 40 metastatic melanoma (MM) samples, composed of 22 bulky, macroscopic (replaced) lymph node metastases, 16 subcutaneous and 2 distant metastases (adrenal and brain), to 42 primary cutaneous cancers, comprised of 16 melanoma, 11 squamous cell, 15 basal cell skin cancers. A Human Genome U133 Plus 2.0 array from Affymetrix, Inc. was utilized for each sample. A variety of statistical software, including the Affymetrix MAS 5.0 analysis software, was utilized to compare primary cancers to metastatic melanomas. Separate analyses were performed to directly compare only primary melanoma to metastatic melanoma samples. The expression levels of putative oncogenes and tumor suppressor genes were analyzed by semi- and real-time quantitative RT-PCR (qPCR) and Western blot analysis was performed on select genes.</p> <p>Results</p> <p>We find that primary basal cell carcinomas, squamous cell carcinomas and thin melanomas express dramatically higher levels of many genes, including <it>SPRR1A/B</it>, <it>KRT16/17</it>, <it>CD24</it>, <it>LOR</it>, <it>GATA3</it>, <it>MUC15</it>, and <it>TMPRSS4</it>, than metastatic melanoma. In contrast, the metastatic melanomas express higher levels of genes such as <it>MAGE</it>, <it>GPR19</it>, <it>BCL2A1</it>, <it>MMP14</it>, <it>SOX5</it>, <it>BUB1</it>, <it>RGS20</it>, and more. The transition from non-metastatic expression levels to metastatic expression levels occurs as melanoma tumors thicken. We further evaluated primary melanomas of varying Breslow's tumor thickness to determine that the transition in expression occurs at different thicknesses for different genes suggesting that the "transition zone" represents a critical time for the emergence of the metastatic phenotype. Several putative tumor oncogenes (<it>SPP-1</it>, <it>MITF</it>, <it>CITED-1</it>, <it>GDF-15</it>, <it>c-Met</it>, <it>HOX </it>loci) and suppressor genes (<it>PITX-1</it>, <it>CST-6</it>, <it>PDGFRL</it>, <it>DSC-3</it>, <it>POU2F3</it>, <it>CLCA2</it>, <it>ST7L</it>), were identified and validated by quantitative PCR as changing expression during this transition period. These are strong candidates for genes involved in the progression or suppression of the metastatic phenotype.</p> <p>Conclusion</p> <p>The gene expression profiling of primary, non-metastatic cutaneous tumors and metastatic melanoma has resulted in the identification of several genes that may be centrally involved in the progression and metastatic potential of melanoma. This has very important implications as we continue to develop an improved understanding of the metastatic process, allowing us to identify specific genes for prognostic markers and possibly for targeted therapeutic approaches.</p

Cystatin A, a Potential Common Link for Mutant Myocilin Causative Glaucoma

Myocilin (MYOC) is a 504 aa secreted glycoprotein induced by stress factors in the trabecular meshwork tissue of the eye, where it was discovered. Mutations in MYOC are linked to glaucoma. The glaucoma phenotype of each of the different MYOC mutation varies, but all of them cause elevated intraocular pressure (IOP). In cells, forty percent of wild-type MYOC is cleaved by calpain II, a cysteine protease. This proteolytic process is inhibited by MYOC mutants. In this study, we investigated the molecular mechanisms by which MYOC mutants cause glaucoma. We constructed adenoviral vectors with variants Q368X, R342K, D380N, K423E, and overexpressed them in human trabecular meshwork cells. We analyzed expression profiles with Affymetrix U133Plus2 GeneChips using wild-type and null viruses as controls. Analysis of trabecular meshwork relevant mechanisms showed that the unfolded protein response (UPR) was the most affected. Search for individual candidate genes revealed that genes that have been historically connected to trabecular meshwork physiology and pathology were altered by the MYOC mutants. Some of those had known MYOC associations (MMP1, PDIA4, CALR, SFPR1) while others did not (EDN1, MGP, IGF1, TAC1). Some, were top-changed in only one mutant (LOXL1, CYP1B1, FBN1), others followed a mutant group pattern. Some of the genes were new (RAB39B, STC1, CXCL12, CSTA). In particular, one selected gene, the cysteine protease inhibitor cystatin A (CSTA), was commonly induced by all mutants and not by the wild-type. Subsequent functional analysis of the selected gene showed that CSTA was able to reduce wild-type MYOC cleavage in primary trabecular meshwork cells while an inactive mutated CSTA was not. These findings provide a new molecular understanding of the mechanisms of MYOC-causative glaucoma and reveal CSTA, a serum biomarker for cancer, as a potential biomarker and drug for the treatment of MYOC-induced glaucoma