1,938 research outputs found
Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans
A cDNA corresponding to a known G protein alpha subunit, the alpha subunit of Go (Go alpha), was isolated and sequenced. The predicted amino acid sequence of C. elegans Go alpha is 80-87% identical to other Go alpha sequences. An mRNA that hybridizes to the C. elegans Go alpha cDNA can be detected on Northern blots. A C. elegans protein that crossreacts with antibovine Go alpha antibody can be detected on immunoblots. A cosmid clone containing the C. elegans Go alpha gene (goa-1) was isolated and mapped to chromosome I. The genomic fragments of three other C. elegans G protein alpha subunit genes (gpa-1, gpa-2, and gpa-3) have been isolated using the polymerase chain reaction. The corresponding cosmid clones were isolated and mapped to disperse locations on chromosome V. The sequences of two of the genes, gpa-1 and gpa-3, were determined. The predicted amino acid sequences of gpa-1 and gpa-3 are only 48% identical to each other. Therefore, they are likely to have distinct functions. In addition they are not homologous enough to G protein alpha subunits in other organisms to be classified. Thus C. elegans has G proteins that are identifiable homologues of mammalian G proteins as well as G proteins that appear to be unique to C. elegans. Study of identifiable G proteins in C. elegans may result in a further understanding of their function in other organisms, whereas study of the novel G proteins may provide an understanding of unique aspects of nematode physiology
Vanishing of Gravitational Particle Production in the Formation of Cosmic Strings
We consider the gravitationally induced particle production from the quantum
vacuum which is defined by a free, massless and minimally coupled scalar field
during the formation of a gauge cosmic string. Previous discussions of this
topic estimate the power output per unit length along the string to be of the
order of ergs/sec/cm in the s-channel. We find that this production
may be completely suppressed. A similar result is also expected to hold for the
number of produced photons.Comment: 10 pages, Plain LaTex. Minor improvements. To appear in PR
The Isgur-Wise function in a relativistic model for system
We use the Dirac equation with a ``(asymptotically free) Coulomb + (Lorentz
scalar) linear '' potential to estimate the light quark wavefunction for mesons in the limit . We use these wavefunctions to
calculate the Isgur-Wise function for orbital and radial
ground states in the phenomenologically interesting range . We find a simple expression for the zero-recoil slope, , where is the energy eigenvalue
of the light quark, which can be identified with the parameter
of the Heavy Quark Effective Theory. This result implies an upper bound of
for the slope . Also, because for a very light quark the size of the meson is determined mainly by the
``confining'' term in the potential , the shape of
is seen to be mostly sensitive to the dimensionless
ratio . We present results for the ranges of
parameters , and
light quark masses and compare to existing
experimental data and other theoretical estimates. Fits to the data give:
,
and [ARGUS
'93]; , and
[CLEO '93]; ${\bar\Lambda_{u,d}}^2/Comment: 22 pages, Latex, 4 figures (not included) available by fax or via
email upon reques
Two Neuronal G Proteins are Involved in Chemosensation of the Caenorhabditis elegans Dauer-Inducing Pheromone
Caenorhabditis elegans uses chemosensation to determine its course of development. Young larvae can arrest as dauer larvae in response to increasing population density, which they measure by a nematode-excreted pheromone, and decreasing food supply. Dauer larvae can resume development in response to a decrease in pheromone and increase in food concentration. We show here that two novel G protein alpha subunits (GPA-2 and GPA-3) show promoter activity in subsets of chemosensory neurons and are involved in the decision to form dauer larvae primarily through the response to dauer pheromone. Dominant activating mutations in these G proteins result in constitutive, pheromone-independent dauer formation, whereas inactivation results in reduced sensitivity to pheromone, and, under certain conditions, an alteration in the response to food. Interactions between gpa-2, gpa-3 and other genes controlling dauer formation suggest that these G proteins may act in parallel to regulate the neuronal decision making that precedes dauer formation
Limitations to Frechet's Metric Embedding Method
Frechet's classical isometric embedding argument has evolved to become a
major tool in the study of metric spaces. An important example of a Frechet
embedding is Bourgain's embedding. The authors have recently shown that for
every e>0 any n-point metric space contains a subset of size at least n^(1-e)
which embeds into l_2 with distortion O(\log(2/e) /e). The embedding we used is
non-Frechet, and the purpose of this note is to show that this is not
coincidental. Specifically, for every e>0, we construct arbitrarily large
n-point metric spaces, such that the distortion of any Frechet embedding into
l_p on subsets of size at least n^{1/2 + e} is \Omega((\log n)^{1/p}).Comment: 10 pages, 1 figur
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