427 research outputs found
Generalized orientations and the Bloch invariant
Abstract. For compact hyperbolic 3-manifolds we lift the Bloch invariant defined by Neumann and Yang to an integral class in K3(C). Applying the Borel and the Bloch regulators, one gets back the volume and the Chern-Simons invariant of the manifold. We also discuss the non-compact case, in which there appears a Z/2-ambiguity
Observation of Three-dimensional Long-range Order in Smaller Ion Coulomb Crystals in an rf Trap
Three-dimensional long-range ordered structures in smaller and
near-spherically symmetric Coulomb crystals of ^{40}Ca^+ ions confined in a
linear rf Paul trap have been observed when the number of ions exceeds ~1000
ions. This result is unexpected from ground state molecular dynamics (MD)
simulations, but found to be in agreement with MD simulations of metastable ion
configurations. Previously, three-dimensional long-range ordered structures
have only been reported in Penning traps in systems of ~50,000 ions or more.Comment: 5 pages; 4 figures; to appear in Phys. Rev. Lett.; changed content
Human anti-CD30 recombinant antibodies by guided phage antibody selection using cell panning
In various clinical studies, Hodgkin’s patients have been treated with anti-CD30 immunotherapeutic agents and have shown promising responses. One of the problems that appeared from these studies is the development of an immune response against the non-human therapeutics, which limits repeated administration and reduces efficacy. We have set out to make a recombinant, human anti-CD30 single-chain variable fragment (scFv) antibody, which may serve as a targeting moiety with reduced immunogenicity and more rapid tumour penetration in similar clinical applications. Rather than selecting a naive phage antibody library on recombinant CD30 antigen, we used guided selection of a murine antibody in combination with panning on the CD30-positive cell line L540. The murine monoclonal antibody Ki-4 was chosen as starting antibody, because it inhibits the shedding of the extracellular part of the CD30 antigen. This makes the antibody better suited for CD30-targeting than most other anti-CD30 antibodies. We have previously isolated the murine Ki-4 scFv by selecting a mini-library of hybridoma-derived phage scFv-antibodies via panning on L540 cells. Here, we report that phage display technology was successfully used to obtain a human Ki-4 scFv version by guided selection. The murine variable heavy (VH) and light (VL) chain genes of the Ki-4 scFv were sequentially replaced by human V gene repertoires, while retaining only the major determinant for epitope-specificity: the heavy-chain complementarity determining region 3 (CDR3) of murine Ki-4. After two rounds of chain shuffling and selection by panning on L540 cells, a fully human anti-CD30 scFv was selected. It competes with the parental monoclonal antibody Ki-4 for binding to CD30, inhibits the shedding of the extracellular part of the CD30 receptor from L540 cells and is thus a promising candidate for the generation of anti-CD30 immunotherapeutics. © 2000 Cancer Research Campaig
A family case of fertile human 45,X,psu dic(15;Y) males
We report on a familial case including four male probands from three generations with a 45,X,psu dic(15;Y)(p11.2;q12) karyotype. 45,X is usually associated with a female phenotype and only rarely with maleness, due to translocation of small Y chromosomal fragments to autosomes. These male patients are commonly infertile because of missing azoospermia factor regions from the Y long arm. In our familial case we found a pseudodicentric translocation chromosome, that contains almost the entire chromosomes 15 and Y. The translocation took place in an unknown male ancestor of our probands and has no apparent effect on fertility and phenotype of the carrier. FISH analysis demonstrated the deletion of the pseudoautosomal region 2 (PAR2) from the Y chromosome and the loss of the nucleolus organizing region (NOR) from chromosome 15. The formation of the psu dic(15;Y) chromosome is a reciprocal event to the formation of the satellited Y chromosome (Yqs). Statistically, the formation of 45,X,psu dic(15;Y) (p11.2;q12) is as likely as the formation of Yqs. Nevertheless, it has not been described yet. This can be explained by the dicentricity of this translocation chromosome that usually leads to mitotic instability and meiotic imbalances. A second event, a stable inactivation of one of the two centromeres is obligatory to enable the transmission of the translocation chromosome and thus a stably reduced chromosome number from father to every son in this family
The Density of States in High-Tc Superconductors Vortices
We calculated the electronic structure of a vortex in a pseudogapped
superconductor within a model featuring strong correlations. With increasing
strength of the correlations, the BCS core states are suppressed and the
spectra in and outside the core become similar. If the correlations are
short-range, we find new core states in agreement with the observations in
YBaCuO and BiSrCaCuO. Our results point to a common phenomenology for these two
systems and indicate that normal-state correlations survive below Tc without
taking part in the overall phase coherence.Comment: REVTeX 4, 5 pages, 2 EPS figures. Some changes to the text; new
figures; references update
FAPRI 2004 U.S. and World Agricultural Outlook
Crop Production/Industries, Livestock Production/Industries,
KO-Homology and Type I String Theory
We study the classification of D-branes and Ramond-Ramond fields in Type I
string theory by developing a geometric description of KO-homology. We define
an analytic version of KO-homology using KK-theory of real C*-algebras, and
construct explicitly the isomorphism between geometric and analytic
KO-homology. The construction involves recasting the Cl(n)-index theorem and a
certain geometric invariant into a homological framework which is used, along
with a definition of the real Chern character in KO-homology, to derive
cohomological index formulas. We show that this invariant also naturally
assigns torsion charges to non-BPS states in Type I string theory, in the
construction of classes of D-branes in terms of topological KO-cycles. The
formalism naturally captures the coupling of Ramond-Ramond fields to background
D-branes which cancel global anomalies in the string theory path integral. We
show that this is related to a physical interpretation of bivariant KK-theory
in terms of decay processes on spacetime-filling branes. We also provide a
construction of the holonomies of Ramond-Ramond fields in Type II string theory
in terms of topological K-chains.Comment: 40 pages; v4: Clarifying comments added, more detailed proof of main
isomorphism theorem given; Final version to be published in Reviews in
Mathematical Physic
FAPRI 2001 U.S. and World Agricultural Outlook
Crop Production/Industries, Livestock Production/Industries,
FAPRI 2005 U.S. and World Agricultural Outlook
Crop Production/Industries, Livestock Production/Industries,
FAPRI 2002 World Agricultural Outlook
Crop Production/Industries, Livestock Production/Industries,
- …