285 research outputs found
Apoptosis and proliferation in the trigeminal placode
The neurogenic trigeminal placode develops from the crescent-shaped panplacodal primordium which delineates the neural plate anteriorly. We show that, in Tupaia belangeri, the trigeminal placode is represented by a field of focal ectodermal thickenings which over time changes positions from as far rostral as the level of the forebrain to as far caudal as opposite rhombomere 3. Delamination proceeds rostrocaudally from the ectoderm adjacent to the rostral midbrain, and contributes neurons to the trigeminal ganglion as well as to the ciliary ganglion/oculomotor complex. Proliferative events are centered on the field prior to the peak of delamination. They are preceded, paralleled and, finally, outnumbered by apoptotic events which proceed rostrocaudally from non-delaminating to delaminating parts of the field. Apoptosis persists upon regression of the placode, thereby exhibiting a massive “wedge” of apoptotic cells which includes the postulated position of the “ventrolateral postoptic placode” (Lee et al. in Dev Biol 263:176–190, 2003), merges with groups of lens-associated apoptotic cells, and disappears upon lens detachment. In conjunction with earlier work (Washausen et al. in Dev Biol 278:86–102, 2005) our findings suggest that apoptosis contributes repeatedly to the disintegration of the panplacodal primordium, to the elimination of subsets of premigratory placodal neuroblasts, and to the regression of placodes
Quantum spin models with exact dimer ground states
Inspired by the exact solution of the Majumdar-Ghosh model, a family of
one-dimensional, translationally invariant spin hamiltonians is constructed.
The exchange coupling in these models is antiferromagnetic, and decreases
linearly with the separation between the spins. The coupling becomes
identically zero beyond a certain distance. It is rigorously proved that the
dimer configuration is an exact, superstable ground state configuration of all
the members of the family on a periodic chain. The ground state is two-fold
degenerate, and there exists an energy gap above the ground state. The
Majumdar-Ghosh hamiltonian with two-fold degenerate dimer ground state is just
the first member of the family.
The scheme of construction is generalized to two and three dimensions, and
illustrated with the help of some concrete examples. The first member in two
dimensions is the Shastry-Sutherland model. Many of these models have
exponentially degenerate, exact dimer ground states.Comment: 10 pages, 8 figures, revtex, to appear in Phys. Rev.
Complete Genome Sequences of Paenibacillus Larvae Phages BN12, Dragolir, Kiel007, Leyra, Likha, Pagassa, PBL1c, and Tadhana
We present here the complete genomes of eight phages that infect Paenibacillus larvae, the causative agent of American foulbrood in honeybees. Phage PBL1c was originally isolated in 1984 from a P. larvae lysogen, while the remaining phages were isolated in 2014 from bee debris, honeycomb, and lysogens from three states in the USA
Elementary excitations in the gapped phase of a frustrated S=1/2 spin ladder: from spinons to the Haldane triplet
We use the variational matrix-product ansatz to study elementary excitations
in the S=1/2 ladder with additional diagonal coupling, equivalent to a single
S=1/2 chain with alternating exchange and next-nearest neighbor interaction. In
absence of alternation the elementary excitation consists of two free S=1/2
particles ("spinons") which are solitons in the dimer order. When the
nearest-neighbor exchange alternates, the "spinons" are confined into one S=1
excitation being a soliton in the generalized string order. Variational results
are found to be in a qualitative agreement with the exact diagonalization data
for 24 spins. We argue that such an approach gives a reasonably good
description in a wide range of the model parameters.Comment: RevTeX, 13 pages, 11 embedded figures, uses psfig and multico
An extended massless phase and the Haldane phase in a spin-1 isotropic antiferromagnetic chain
We study the phase transition of isotropic spin-1 models in the vicinity of
the Uimin-Lai-Sutherland model by using the SU(3)_1 WZW model with certain
marginal perturbations. The unstable RG trajectory by a marginally relevant
perturbation generates a mass gap for the Haldane phase, and thus the
universality class of the transition from the massless phase to the Haldane
phase at ULS point becomes the BKT type. Our results support recent numerical
studies by F\'ath and S\'olyom. In the massless phase, we calculate logarithmic
finite-size corrections of the energy for the SU(\nu)-symmetric and asymmetric
models.Comment: 19 pages, RevTe
Nuclear Magnetic Relaxation in the Haldane-Gap Antiferromagnet Ni(C_2_H_8_N_2_)_2_NO_2_(ClO_4_)
A new theory is proposed to interpret nuclear spin-lattice relaxation-time
(T_1_) measurements on the spin-1 quasi-one-dimensional Heisenberg
antiferromagnet Ni(C_2_H_8_N_2_)_2_NO_2_(ClO_4_) (NENP). While Sagi and Affleck
pioneeringly discussed this subject in terms of field-theoretical languages,
there is no theoretical attempt yet to explicitly simulate the novel
observations of 1/T_1_ reported by Fujiwara et al.. By means of modified spin
waves, we solve the minimum of 1/T_1_ as a function of an applied field,
pending for the past decade.Comment: to be published in J. Phys. Soc. Jpn. 73, No. 4 (2004
Discovery and characterization of small molecules that target the Ral GTPase
The Ras-like GTPases RalA and B are important drivers of tumor growth and metastasis. Chemicals that block Ral function would be valuable as research tools and for cancer therapeutics. Here, we used protein structure analysis and virtual screening to identify drug-like molecules that bind a site on the GDP-form of Ral. Compounds RBC6, RBC8 and RBC10 inhibited Ral binding to its effector RalBP1, Ral-mediated cell spreading in murine fibroblasts and anchorage-independent growth of human cancer cell lines. Binding of RBC8 derivative BQU57 to RalB was confirmed by isothermal titration calorimetry, surface plasma resonance and 15N-HSQC NMR. RBC8 and BQU57 show selectivity for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA. Our results show the utility of structure-based discovery for development of therapeutics for Ral-dependent cancers
The spectral gap for some spin chains with discrete symmetry breaking
We prove that for any finite set of generalized valence bond solid (GVBS)
states of a quantum spin chain there exists a translation invariant
finite-range Hamiltonian for which this set is the set of ground states. This
result implies that there are GVBS models with arbitrary broken discrete
symmetries that are described as combinations of lattice translations, lattice
reflections, and local unitary or anti-unitary transformations. We also show
that all GVBS models that satisfy some natural conditions have a spectral gap.
The existence of a spectral gap is obtained by applying a simple and quite
general strategy for proving lower bounds on the spectral gap of the generator
of a classical or quantum spin dynamics. This general scheme is interesting in
its own right and therefore, although the basic idea is not new, we present it
in a system-independent setting. The results are illustrated with an number of
examples.Comment: 48 pages, Plain TeX, BN26/Oct/9
Multi-plateau magnetization curves of one-dimensional Heisenberg ferrimagnets
Ground-state magnetization curves of ferrimagnetic Heisenberg chains of
alternating spins and are numerically investigated. Calculating several
cases of , we conclude that the spin- chain generally exhibits
magnetization plateaux even at the most symmetric point. In the double- or
more-plateau structure, the initial plateau is generated on a classical basis,
whereas the higher ones are based on a quantum mechanism.Comment: 6 pages, 6 figures embedded, to appear in Phys. Rev. B 01 August 200
- …