212 research outputs found
Tectonomagmatic Evolution of Southwestern Laurentia: Insights from Zircon U-Pb Geochronology and Hafnium Isotopic Composition of the Red Bluff Granite Suite, West Texas, USA
We provide laser ablation–multicollector–inductively coupled plasma–mass spectrometry (LA-MC-ICP-MS) and high-precision chemical abrasion–isotope dilution–thermal ionization mass spectrometry (CA-ID-TIMS) U-Pb ages and Hf isotopic compositions of zircons from the Red Bluff Granite Suite and mafic dikes in the Franklin Mountains of El Paso, Texas, USA. Granitoids exposed in the Franklin Mountains were previously divided into five magmatic stages based on cross-cutting relationships. Major and trace element compositions showed that these granitoids are ferroan, alkaline, and A2 type. Homogeneity in the whole-rock geochemistry suggests that the granite stages are genetically related and share similar petrogenetic histories. Weighted mean zircon 206Pb/238U dates from the older magmatic stage 1 alkali-feldspar quartz syenite and stage 2 alkali-feldspar granite are 1112.36 ± 0.35 and 1112.46 ± 0.37 Ma, respectively. The weighted mean εHf(t) values varying from +5.3 to +7.2 are similar to those of other regional ca. 1.1 Ga magmatic rocks throughout southwestern Laurentia. Geochemical characteristics, petrological modeling, and enriched Hf isotopic composition suggest fractional crystallization of a basaltic magma that was produced by melting of an enriched mantle reservoir. However, zircon inheritance ages of ca. 1.3 Ga and 1.26–1.15 Ga are consistent with a minor contribution from felsic crustal basement. Our data and regional geology are consistent with a post-collisional slab break-off that facilitated asthenospheric upwelling and partial melting of the enriched mantle, possibly subcontinental lithospheric mantle, extending from Llano Uplift, Texas, in the southeast to California to the northwest. Magma thus generated upon differentiation produced ferroan and A-type granitoids
Persistent Currents in Multichannel Interacting Systems
Persistent currents of disordered multichannel mesoscopic rings of spinless
interacting fermions threaded by a magnetic flux are calculated using exact
diagonalizations and self-consistent Hartree-Fock methods. The validity of the
Hartree-Fock approximation is controled by a direct comparison with the exact
results on small clusters. For sufficiently large disorder
(diffusive regime), the effect of repulsive interactions on the current
distribution is to slightly decrease its width (mean square current) but to
{\it increase} its mean value (mean current). This effect is stronger in the
case of a long range repulsion. Our results suggest that the coupling between
the chains is essential to understand the large currents observed
experimentally.Comment: Revised version, uuencoded compressed file including fig
Single parameter scaling in one-dimensional localization revisited
The variance of the Lyapunov exponent is calculated exactly in the
one-dimensional Anderson model with random site energies distributed according
to the Cauchy distribution. We find a new significant scaling parameter in the
system, and derive an exact analytical criterion for single parameter scaling
which differs from the commonly used condition of phase randomization. The
results obtained are applied to the Kronig-Penney model with the potential in
the form of periodically positioned -functions with random strength.Comment: Phys. Rev. Lett. 84, 2678 (2000
Sublocalization, superlocalization, and violation of standard single parameter scaling in the Anderson model
We discuss the localization behavior of localized electronic wave functions
in the one- and two-dimensional tight-binding Anderson model with diagonal
disorder. We find that the distributions of the local wave function amplitudes
at fixed distances from the localization center are well approximated by
log-normal fits which become exact at large distances. These fits are
consistent with the standard single parameter scaling theory for the Anderson
model in 1d, but they suggest that a second parameter is required to describe
the scaling behavior of the amplitude fluctuations in 2d. From the log-normal
distributions we calculate analytically the decay of the mean wave functions.
For short distances from the localization center we find stretched exponential
localization ("sublocalization") in both, 1d and 2d. In 1d, for large
distances, the mean wave functions depend on the number of configurations N
used in the averaging procedure and decay faster that exponentially
("superlocalization") converging to simple exponential behavior only in the
asymptotic limit. In 2d, in contrast, the localization length increases
logarithmically with the distance from the localization center and
sublocalization occurs also in the second regime. The N-dependence of the mean
wave functions is weak. The analytical result agrees remarkably well with the
numerical calculations.Comment: 12 pages with 9 figures and 1 tabl
Anderson-localization versus delocalization of interacting fermions in one dimension
Using the density matrix renormalization group algorithm, we investigate the
lattice model for spinless fermions in one dimension in the presence of a
strong interaction and disorder. The phase sensitivity of the ground state
energy is determined with high accuracy for systems up to a size of 60 lattice
constants. This quantity is found to be log-normally distributed. The
fluctuations grow algebraically with system size with a universal exponent of
~2/3 in the localized region of the phase diagram. Surprizingly, we find, for
an attractive interaction, a delocalized phase of finite extension. The
boundary of this delocalized phase is determined.Comment: 5 pages, 6 figures, revte
Surgical management of dural arteriovenous fistulas with transosseous arterial feeders involving the jugular bulb
Dural arteriovenous fistulas located in the vicinity of the jugular foramen are complex vascular malformations and belong to the most challenging skull base lesions to treat. The authors comprehensively analyze multiple features in a series of dural arteriovenous fistulas with transosseous arterial feeders involving the jugular bulb. Four patients who underwent surgery via the transcondylar approach to treat dural arteriovenous fistulas around the jugular foramen were retrospectively reviewed. Previously, endovascular treatment was attempted in all patients. The success of the surgical treatment was examined with postoperative angiography. Complete obliteration of the dural arteriovenous fistulas (DAVFs) was achieved in three patients, and significant flow reduction in one individual. All patients had a good postoperative outcome, and only one experienced mild hypoglossal nerve palsy. Despite extensive bone drilling, an occipitocervical fusion was necessary in only one patient with bilateral lesions. The use of an individually tailored transcondylar approach to treat dural arteriovenous fistulas at the region of the jugular foramen is most effective. This approach allows for complete obliteration of the connecting arterial feeders, and removal of bony structures containing pathological vessels
Internal Jugular Vein Cross-Sectional Area Enlargement Is Associated with Aging in Healthy Individuals.
Internal jugular vein (IJV) narrowing has been implicated in central nervous system pathologies, however normal physiological age- and gender-related IJV variance in healthy individuals (HIs) has not been adequately assessed.We assessed the relationship between IJV cross-sectional area (CSA) and aging.This study involved 193 HIs (63 males and 130 females) who received 2-dimensional magnetic resonance venography at 3T. The minimum CSA of the IJVs at cervical levels C2/C3, C4, C5/C6, and C7/T1 was obtained using a semi-automated contouring-thresholding technique. Subjects were grouped by decade. Pearson and partial correlation (controlled for cardiovascular risk factors, including hypertension, heart disease, smoking and body mass index) and analysis of variance analyses were used, with paired t-tests comparing side differences.Mean right IJV CSA ranges were: in males, 41.6 mm2 (C2/C3) to 82.0 mm2 (C7/T1); in females, 38.0 mm2 (C2/C3) to 62.3 mm2 (C7/T1), while the equivalent left side ranges were: in males, 28.0 mm2 (C2/C3) to 52.2 mm2 (C7/T1); in females, 27.2 mm2 (C2/C3) to 47.8 mm2 (C7/T1). The CSA of the right IJVs was significantly larger (p<0.001) than the left at all cervical levels. Controlling for cardiovascular risk factors, the correlation between age and IJV CSA was more robust in males than in the females for all cervical levels.In HIs age, gender, hand side and cervical location all affect IJV CSA. These findings suggest that any definition of IJV stenosis needs to account for these factors
Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells
Small molecules have been shown to be potent and selective probes to understand cell physiology. Here, we show that imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines compose a class of compounds that target essential, conserved cellular processes. Using validated chemogenomic assays in Saccharomyces cerevisiae, we discovered that two closely related compounds, an imidazo[1,2-a]pyridine and -pyrimidine that differ by a single atom, have distinctly different mechanisms of action in vivo. 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine was toxic to yeast strains with defects in electron transport and mitochondrial functions and caused mitochondrial fragmentation, suggesting that compound 13 acts by disrupting mitochondria. By contrast, 2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine acted as a DNA poison, causing damage to the nuclear DNA and inducing mutagenesis. We compared compound 15 to known chemotherapeutics and found resistance required intact DNA repair pathways. Thus, subtle changes in the structure of imidazo-pyridines and -pyrimidines dramatically alter both the intracellular targeting of these compounds and their effects in vivo. Of particular interest, these different modes of action were evident in experiments on human cells, suggesting that chemical–genetic profiles obtained in yeast are recapitulated in cultured cells, indicating that our observations in yeast can: (1) be leveraged to determine mechanism of action in mammalian cells and (2) suggest novel structure–activity relationships
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