Turning off the Lights: How Dark is Dark Matter?

We consider current observational constraints on the electromagnetic charge of dark matter. The velocity dependence of the scattering cross-section through the photon gives rise to qualitatively different constraints than standard dark matter scattering through massive force carriers. In particular, recombination epoch observations of dark matter density perturbations require that $\epsilon$, the ratio of the dark matter to electronic charge, is less than $10^{-6}$ for $m_X = 1 GeV$, rising to $\epsilon < 10^{-4}$ for $m_X = 10 TeV$. Though naively one would expect that dark matter carrying a charge well below this constraint could still give rise to large scattering in current direct detection experiments, we show that charged dark matter particles that could be detected with upcoming experiments are expected to be evacuated from the Galactic disk by the Galactic magnetic fields and supernova shock waves, and hence will not give rise to a signal. Thus dark matter with a small charge is likely not a source of a signal in current or upcoming dark matter direct detection experiments.Comment: 19 pages, 2 figures; v2 - figures fixed, references adde

Sommerfeld Enhancements for Thermal Relic Dark Matter

The annihilation cross section of thermal relic dark matter determines both its relic density and indirect detection signals. We determine how large indirect signals may be in scenarios with Sommerfeld-enhanced annihilation, subject to the constraint that the dark matter has the correct relic density. This work refines our previous analysis through detailed treatments of resonant Sommerfeld enhancement and the effect of Sommerfeld enhancement on freeze out. Sommerfeld enhancements raise many interesting issues in the freeze out calculation, and we find that the cutoff of resonant enhancement, the equilibration of force carriers, the temperature of kinetic decoupling, and the efficiency of self-interactions for preserving thermal velocity distributions all play a role. These effects may have striking consequences; for example, for resonantly-enhanced Sommerfeld annihilation, dark matter freezes out but may then chemically recouple, implying highly suppressed indirect signals, in contrast to naive expectations. In the minimal scenario with standard astrophysical assumptions, and tuning all parameters to maximize the signal, we find that, for force-carrier mass m_phi = 250 MeV and dark matter masses m_X = 0.1, 0.3, and 1 TeV, the maximal Sommerfeld enhancement factors are S_eff = 7, 30, and 90, respectively. Such boosts are too small to explain both the PAMELA and Fermi excesses. Non-minimal models may require smaller boosts, but the bounds on S_eff could also be more stringent, and dedicated freeze out analyses are required. For concreteness, we focus on 4 mu final states, but we also discuss 4 e and other modes, deviations from standard astrophysical assumptions and non-minimal particle physics models, and we outline the steps required to determine if such considerations may lead to a self-consistent explanation of the PAMELA or Fermi excesses.Comment: 31 pages, published versio

Study of CP violation in Λc+\Lambda_c^+ decay

In this paper, we study CP violation in $\Lambda_c^+\to BP$ and $\Lambda_c^+\to BV$ decays, where $B,P$ and $V$ denote a light spin-1/2 baryon, pseudoscalar and a vector meson respectively. In these processes the $T$ odd CP violating triple-product (TP) correlations are examined. The genuine CP violating observables which are composed of the helicity amplitudes occurring in the angular distribution are constructed. Experimentally, by performing a full angular analysis it is shown how one may extract the helicity amplitudes and then obtain the TP asymmetries. We estimate the TP asymmetries in \lam decays to be negligible in the standard model making these processes an excellent place to look for new physics. Taking a two Higgs doublet model, as an example of new physics, we show that large TP asymmetries are possible in these decays. Finally, we discuss how BES-III and Super $\tau$-Charm experiments will be sensitive to these CP violating signals in $\Lambda_c^+$ decays.Comment: 7 pages, 2 tables. Journal reference is adde

An Updated Search of Steady TeV γ−\gamma-Ray Point Sources in Northern Hemisphere Using the Tibet Air Shower Array

Using the data taken from Tibet II High Density (HD) Array (1997 February-1999 September) and Tibet-III array (1999 November-2005 November), our previous northern sky survey for TeV $\gamma-$ray point sources has now been updated by a factor of 2.8 improved statistics. From $0.0^{\circ}$ to $60.0^{\circ}$ in declination (Dec) range, no new TeV $\gamma-$ray point sources with sufficiently high significance were identified while the well-known Crab Nebula and Mrk421 remain to be the brightest TeV $\gamma-$ray sources within the field of view of the Tibet air shower array. Based on the currently available data and at the 90% confidence level (C.L.), the flux upper limits for different power law index assumption are re-derived, which are approximately improved by 1.7 times as compared with our previous reported limits.Comment: This paper has been accepted by hepn

AI protein structure prediction-based modeling and mutagenesis of a protostome receptor and peptide ligands reveal key residues for their interaction

The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. Despite the progress, molecular mechanisms governing LK peptide–receptor interactions remain to be elucidated. Previously, we identified a precursor protein for Aplysia leucokinin-like peptides (ALKs) that contains the greatest number of amidated peptides among LK precursors in all species identified so far. Here, we identified the first ALK receptor from Aplysia, ALKR. We used cell-based IP1 activation assays to demonstrate that two ALK peptides with the most copies, ALK1 and ALK2, activated ALKR with high potencies. Other endogenous ALK-derived peptides bearing the FXXWX-amide motif also activated ALKR to various degrees. Our examination of cross-species activity of ALKs with the Anopheles LK receptor was consistent with a critical role for the FXXWX-amide motif in receptor activity. Furthermore, we showed, through alanine substitution of ALK1, the highly conserved phenylalanine (F), tryptophan (W), and C-terminal amidation were each essential for receptor activation. Finally, we used an artificial intelligence– based protein structure prediction server (Robetta) and Autodock Vina to predict the ligand-bound conformation of ALKR. Our model predicted several interactions (i.e., hydrophobic interactions, hydrogen bonds, and amide-pi stacking) between ALK peptides and ALKR, and several of our substitution and mutagenesis experiments were consistent with the predicted model. In conclusion, our results provide important information defining possible interactions between ALK peptides and their receptors. The workflow utilized here may be useful for studying other ligand–receptor interactions for a neuropeptide signaling system, particularly in protostomes

Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro

Although peroxisome proliferator-activated receptor gamma (PPARγ) agonist have been shown to inhibit hepatocellular carcinoma (HCC) development, the role of PPARγ in hepatocarcinogenesis remains unclear. We investigated the therapeutic efficacy of PPAR

A possible signature of new physics at BES-III

The recent observations of the purely leptonic decay \Ds \to \mu^+ \nu_{\mu} and $\tau^+\nu_{\tau}$ at CLEO-c and $B$ factory may allow a possible contribution from a charged Higgs boson. One such measurement of the decay constant $f_{D_s}$ differs from the most precise unquenched lattice QCD calculation by 4 $\sigma$ level. Meanwhile, the measured ratio, {\cal BR}(\Ds \to \mu^+ \nu_{\mu}) / {\cal BR}(\Dp \to \mu^+ \nu_{\mu}), is larger than the standard model prediction at 2.0$\sigma$ level. We discuss that the precise measurement of the ratio {\cal BR}(\Ds \to \mu^+ \nu_{\mu}) / {\cal BR}(\Dp \to \mu^+ \nu_{\mu}) at BES-III will shed light on the presence of new intermediate particles by comparing the theoretical predictions, especially, the predictions of high precise unquenched lattice QCD calculation.Comment: 5 pages, 3 figures, mini-review, accepted by Chinese Physics C (HEP & NP

BCAR1 Protein Plays Important Roles in Carcinogenesis and Predicts Poor Prognosis in Non-Small-Cell Lung Cancer

Objective: Our previous study suggested the potential clinical implications of BCAR1 in non-small-cell lung cancer (NSCLC) (Mol Diagn Ther. 2011. 15(1): 31–40). Herein, we aim to evaluate the predictive power of BCAR1 as a marker for poor prognosis in NSCLC cases, verify the carcinogenic roles of BCAR1 in the A549 lung adenocarcinoma cell line, and testify to the BCAR1/phospho-p38 axis. Methods: Between January 2006 and June 2010, there were a total of 182 patients with NSCLC (151 cases with available follow up data, and 31 cases lost to follow-up due to the invalid contact information). We inspected BCAR1, phospho-BCAR1(Tyr410), phospho-p38(Thr180/Tyr182) and p38 expression in NSCLC tissues and matched adjacent normal tissues by immunoblotting and IHC. After BCAR1-RNA interference in A549 cells, we inspected the protein expression (BCAR1, phospho-BCAR1, phospho-p38 and p38) and performed cell biology experiments (cell growth, migration and cycle). Results: BCAR1 was overexpressed in NSCLC tissues (177/182) and cell lines (A549 and Calu-3). However, it was not detected in the normal adjacent tissue in 161 of the 182 cases. Higher BCAR1 levels were strongly associated with more poorly differentiated NSCLC and predicted poorer prognosis. BCAR1 knockdown caused cell growth arrest, cell migration inhibition and cell cycle arrest of A549 cells. Overexpression of BCAR1 was associated with activation of p38 in NSCLC cases, and BCAR1 knockdown caused reduction of phospho-p38 levels in A549 cells

Oscillating Asymmetric Dark Matter

We study the dynamics of dark matter (DM) particle-antiparticle oscillations within the context of asymmetric DM. Oscillations arise due to small DM number-violating Majorana-type mass terms, and can lead to recoupling of annihilation after freeze-out and washout of the DM density. We derive the density matrix equations for DM oscillations and freeze-out from first principles using nonequilibrium field theory, and our results are qualitatively different than in previous studies. DM dynamics exhibits particle-vs-antiparticle "flavor" effects, depending on the interaction type, analogous to neutrino oscillations in a medium. "Flavor-sensitive" DM interactions include scattering or annihilation through a new vector boson, while "flavor-blind" interactions include scattering or s-channel annihilation through a new scalar boson, or annihilation to pairs of bosons. In particular, we find that flavor-sensitive annihilation does not recouple when coherent oscillations begin, and that flavor-blind scattering does not lead to decoherence.Comment: 23 pages, 4 figures, A typo fixed, References adde

Comparison of Double Kissing Crush Versus Culotte Stenting for Unprotected Distal Left Main Bifurcation Lesions Results From a Multicenter, Randomized, Prospective DKCRUSH-III Study

ObjectivesThe study aimed to investigate the difference in major adverse cardiac event (MACE) at 1-year after double kissing (DK) crush versus Culotte stenting for unprotected left main coronary artery (UPLMCA) distal bifurcation lesions.BackgroundDK crush and Culotte stenting were reported to be effective for treatment of coronary bifurcation lesions. However, their comparative performance in UPLMCA bifurcation lesions is not known.MethodsA total of 419 patients with UPLMCA bifurcation lesions were randomly assigned to DK (n = 210) or Culotte (n = 209) treatment. The primary endpoint was the occurrence of a MACE at 1 year, including cardiac death, myocardial infarction, and target vessel revascularization (TVR). In-stent restenosis (ISR) at 8 months was secondary endpoint, and stent thrombosis (ST) served as a safety endpoint. Patients were stratified by SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery) and NERS (New Risk Stratification) scores.ResultsPatients in the Culotte group had significant higher 1-year MACE rate (16.3%), mainly driven by increased TVR (11.0%), compared with the DK group (6.2% and 4.3%, respectively; all p < 0.05). ISR rate in side branch was 12.6% in the Culotte group and 6.8% in the DK group (p = 0.037). Definite ST rate was 1.0% in the Culotte group and 0% in the DK group (p = 0.248). Among patients with bifurcation angle ≥70°, NERS score ≥20, and SYNTAX score ≥23, the 1-year MACE rate in the DK group (3.8%, 9.2%, and 7.1%, respectively) was significantly different to those in the Culotte group(16.5%, 20.4%, and 18.9%, respectively; all p < 0.05).ConclusionsCulotte stenting for UPLMCA bifurcation lesions was associated with significantly increased MACEs, mainly due to the increased TVR. (Double Kissing [DK] Crush Versus Culotte Stenting for the Treatment of Unprotected Distal Left Main Bifurcation Lesions: DKCRUSH-III, a Multicenter Randomized Study Comparing Double-Stent Techniques; ChiCTR-TRC-00000151