Ab initio study of the formation of transparent carbon under pressure

A body-centered tetragonal carbon (bct-Carbon) allotrope has been predicted to be a transparent carbon polymorph obtained under pressure. The structural transition pathways from graphite to diamond, M-Carbon, and bct-Carbon are simulated and the lowest activation barrier is found for the graphite-bct transition. Furthermore, bct-Carbon has higher shear strength than diamond due to its perpendicular graphene-like structure. Our results provide a possible explanation for the formation of a transparent carbon allotrope via the cold compression of graphite. We also verify that this allotrope is hard enough to crack diamond.Comment: [email protected] or [email protected]

Dependence of the decoherence of polarization states in phase-damping channels on the frequency spectrum envelope of photons

We consider the decoherence of photons suffering in phase-damping channels. By exploring the evolutions of single-photon polarization states and two-photon polarization-entangled states, we find that different frequency spectrum envelopes of photons induce different decoherence processes. A white frequency spectrum can lead the decoherence to an ideal Markovian process. Some color frequency spectrums can induce asymptotical decoherence, while, some other color frequency spectrums can make coherence vanish periodically with variable revival amplitudes. These behaviors result from the non-Markovian effects on the decoherence process, which may give rise to a revival of coherence after complete decoherence.Comment: 7 pages, 4 figures, new results added, replaced by accepted versio

Attacking practical quantum key distribution system with wavelength dependent beam splitter and multi-wavelength sources

Unconditional security of quantum key distribution protocol can be guaranteed by the basic property of quantum mechanics. Unfortunately, the practical quantum key distribution system always have some imperfections, and the practical system may be attacked if the imperfection can be controlled by the eavesdropper Eve. Applying the fatal security loophole introduced by the imperfect beam splitter's wavelength dependent optical property, we propose wavelength-dependent attacking model, which can be applied to almost all practical quantum key distribution systems with the passive state modulation and photon state detection after the practical beam splitter. Utilizing our attacking model, we experimentally demonstrate the attacking system based on practical polarization encoding quantum key distribution system with almost 100% success probability. Our result demonstrate that all practical devices require tightened security inspection for avoiding side channel attacks in practical quantum key distribution experimental realizations

Extranuclear Estrogen Receptors Mediate the Neuroprotective Effects of Estrogen in the Rat Hippocampus

17beta-estradiol (E2) has been implicated to exert neuroprotective effects in the brain following cerebral ischemia. Classically, E2 is thought to exert its effects via genomic signaling mediated by interaction with nuclear estrogen receptors. However, the role and contribution of extranuclear estrogen receptors (ER) is unclear and was the subject of the current study.To accomplish this goal, we employed two E2 conjugates (E2 dendrimer, EDC, and E2-BSA) that can interact with extranuclear ER and exert rapid nongenomic signaling, but lack the ability to interact with nuclear ER due to their inability to enter the nucleus. EDC or E2-BSA (10 microM) was injected icv 60 min prior to global cerebral ischemia (GCI). FITC-tagged EDC or E2-BSA revealed high uptake in the hippocampal CA1 region after icv injection, with a membrane (extranuclear) localization pattern in cells. Both EDC and E2-BSA exerted robust neuroprotection in the CA1 against GCI, and the effect was blocked by the ER antagonist, ICI182,780. EDC and E2-BSA both rapidly enhanced activation of the prosurvival kinases, ERK and Akt, while attenuating activation of the proapoptotic kinase, JNK following GCI, effects that were blocked by ICI182,780. Administration of an MEK or PI3K inhibitor blocked the neuroprotective effects of EDC and E2-BSA. Further studies showed that EDC increased p-CREB and BDNF in the CA1 region in an ERK- and Akt-dependent manner, and that cognitive outcome after GCI was preserved by EDC in an ER-dependent manner.In conclusion, the current study demonstrates that activation of extranuclear ER results in induction of ERK-Akt-CREB-BDNF signaling in the hippocampal CA1 region, which significantly reduces ischemic neuronal injury and preserves cognitive function following GCI. The study adds to a growing literature that suggests that extranuclear ER can have important actions in the brain

Hybrid nature of 0846+51W1: a BL Lac object with a narrow line Seyfert 1 nucleus

We have found a NLS1 nucleus in the extensively studied eruptive BL Lac, 0846+51W1, out of a large sample of NLS1 compiled from the spectroscopic dataset of SDSS DR1. Its optical spectrum can be well decomposed into three components, a power law component from the relativistic jet, a stellar component from the host galaxy, and a component from a typical NLS1 nucleus. The emission line properties of 0846+51W1, FWHM(Hbeta) ~ 1710 km s^-1 and [OIII]5007/Hbeta ~ 0.32 when it was in faint state, fulfil the conventional definition of NLS1. Strong FeII emission is detected in the SDSS spectrum, which is also typical of NLS1s. We try to estimate its central black hole mass using various techniques and find that 0846+51W1 is very likely emitting at a few times 10% L_Edd. We speculate that Seyfert-like nuclei, including NLS1s, might be concealed in a significant fraction of BL Lacs but have not been sufficiently explored due to the fact that, by definition, the optical-UV continuum of such kind of objects are often overwhelmed by the synchrotron emission.Comment: ChJAA accepte

Non-perturbative structure of the polarized nucleon sea

We investigate the flavour and quark-antiquark structure of the polarized nucleon by calculating the parton distribution functions of the nucleon sea using the meson cloud model. We find that the SU(2) flavor symmetry in the light antiquark sea and quark-antiquark symmetry in the strange quark sea are broken, {\it i.e.} \Delta\ubar < \Delta \dbar and \Delta s < \Delta \sbar. The polarization of the strange sea is found to be positive, which is in contradiction to previous analyses. We predict a much larger quark-antiquark asymmetry in the polarized strange quark sea than that in the unpolarized strange quark sea. Our results for both polarized light quark sea and polarized strange quark sea are consistent with the recent HERMES data.Comment: RevTex, 17 pages plus 8 PS figure

Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors

This work is licensed under a Creative Commons Attribution 4.0 International License.The blood-brain barrier (BBB) poses a major obstacle by preventing potential therapeutic agents from reaching their intended brain targets at sufficient concentrations. While transient disruption of the BBB has been used to enhance chemotherapeutic efficacy in treating brain tumors, limitations in terms of magnitude and duration of BBB disruption exist. In the present study, the preliminary safety and efficacy profile of HAV6, a peptide that binds to the external domains of cadherin, to transiently open the BBB and improve the delivery of a therapeutic agent, was evaluated in a murine brain tumor model. Transient opening of the BBB in response to HAV6 peptide administration was quantitatively characterized using both a gadolinium magnetic resonance imaging (MRI) contrast agent and adenanthin (Ade), the intended therapeutic agent. The effects of HAV6 peptide on BBB integrity and the efficacy of concurrent administration of HAV6 peptide and the small molecule inhibitor, Ade, in the growth and progression of an orthotopic medulloblastoma mouse model using human D425 tumor cells was examined. Systemic administration of HAV6 peptide caused transient, reversible disruption of BBB in mice. Increases in BBB permeability produced by HAV6 were rapid in onset and observed in all regions of the brain examined. Concurrent administration of HAV6 peptide with Ade, a BBB impermeable inhibitor of Peroxiredoxin-1, caused reduced tumor growth and increased survival in mice bearing medulloblastoma. The rapid onset and transient nature of the BBB modulation produced with the HAV6 peptide along with its uniform disruption and biocompatibility is well-suited for CNS drug delivery applications, especially in the treatment of brain tumors

Genomic analysis of the domestication and post-Spanish conquest evolution of the llama and alpaca

Background Despite their regional economic importance and being increasingly reared globally, the origins and evolution of the llama and alpaca remain poorly understood. Here we report reference genomes for the llama, and for the guanaco and vicuña (their putative wild progenitors), compare these with the published alpaca genome, and resequence seven individuals of all four species to better understand domestication and introgression between the llama and alpaca. Results Phylogenomic analysis confirms that the llama was domesticated from the guanaco and the alpaca from the vicuña. Introgression was much higher in the alpaca genome (36%) than the llama (5%) and could be dated close to the time of the Spanish conquest, approximately 500 years ago. Introgression patterns are at their most variable on the X-chromosome of the alpaca, featuring 53 genes known to have deleterious X-linked phenotypes in humans. Strong genome-wide introgression signatures include olfactory receptor complexes into both species, hypertension resistance into alpaca, and fleece/fiber traits into llama. Genomic signatures of domestication in the llama include male reproductive traits, while in alpaca feature fleece characteristics, olfaction-related and hypoxia adaptation traits. Expression analysis of the introgressed region that is syntenic to human HSA4q21, a gene cluster previously associated with hypertension in humans under hypoxic conditions, shows a previously undocumented role for PRDM8 downregulation as a potential transcriptional regulation mechanism, analogous to that previously reported at high altitude for hypoxia-inducible factor 1α. Conclusions The unprecedented introgression signatures within both domestic camelid genomes may reflect post-conquest changes in agriculture and the breakdown of traditional management practices

Superconductivity at 53.5 K in GdFeAsO1-delta

Here we report the fabrication and superconductivity of the iron-based arsenic-oxide GdFeAsO1-delta compound with oxygen-deficiency, which has an onset resistivity transition temperature at 53.5 K. This material has a same crystal structure as the newly discovered high-Tc ReFeAsO1-delta family (Re = rare earth metal) and a further reduced crystal lattice, while the Tc starts to decrease compared with the SmFeAsO1-delta system

In silico analysis and verification of S100 gene expression in gastric cancer

<p>Abstract</p> <p>Background</p> <p>The S100 protein family comprises 22 members whose protein sequences encompass at least one EF-hand Ca²⁺binding motif. They were involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. However, the expression status of S100 family members in gastric cancer was not known yet.</p> <p>Methods</p> <p>Combined with analysis of series analysis of gene expression, virtual Northern blot and microarray data, the expression levels of S100 family members in normal and malignant stomach tissues were systematically investigated. The expression of S100A3 was further evaluated by quantitative RT-PCR.</p> <p>Results</p> <p>At least 5 S100 genes were found to be upregulated in gastric cance by in silico analysis. Among them, four genes, including S100A2, S100A4, S100A7 and S100A10, were reported to overexpressed in gastric cancer previously. The expression of S100A3 in eighty patients of gastric cancer was further examined. The results showed that the mean expression levels of S100A3 in gastric cancer tissues were 2.5 times as high as in adjacent non-tumorous tissues. S100A3 expression was correlated with tumor differentiation and TNM (Tumor-Node-Metastasis) stage of gastric cancer, which was relatively highly expressed in poorly differentiated and advanced gastric cancer tissues (<it>P </it>< 0.05).</p> <p>Conclusion</p> <p>To our knowledge this is the first report of systematic evaluation of S100 gene expressions in gastric cancers by multiple in silico analysis. The results indicated that overexpression of S100 gene family members were characteristics of gastric cancers and S100A3 might play important roles in differentiation and progression of gastric cancer.</p