Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs

Background and Purpose-N-Methyl-D-aspartate (NMDA) elicits neuronally mediated cerebral arteriolar vasodilation that is reduced by ischemia/reperfusion (I/R). This sequence has been preserved by pretreatment with the ATP-sensitive potassium (K-ATP) channel opener aprikalim, although the mechanism was unclear. In the heart, mitochondrial K-ATP channels (mitoK(ATP)) are involved in the ischemic preconditioning-like effect of K+ channel openers. We determined whether the selective mitoK(ATP) channel opener diazoxide preserves the vascular dilation to NMDA after I/R. Methods-Pial arteriolar diameters were determined with the use of closed cranial window/intravital microscopy in anesthetized piglets. Vascular responses to NMDA were assessed before and 1 hour after 10 minutes of global cerebral ischemia induced by raising intracranial pressure. Subgroups received 1 of the following pretreatments before I/R: vehicle; 1 to 10 mu mol/L diazoxide; and coapplication of 100 mu mol/L 5-hydroxydecanoic acid (5-HD), a K-ATP antagonist with diazoxide. Results-NMDA-induced dose-dependent pial arteriolar dilation was not affected by diazoxide treatment only but was severely attenuated by I/R, In contrast, diazoxide dose-dependently preserved the NMDA vascular response after I/R; at 10 mu mol/L, diazoxide arteriolar responses were unaltered by I/R. The effect of diazoxide was antagonized by coapplication of 5-HD with diazoxide. Percent preservation of 100 mu mol/L NMDA-induced vasodilation after I/R was 53 +/- 19% (mean +/- SEM, n = 8) in vehicle-treated controls versus 55 +/- 10%, 85 +/- 5%, and 99 +/- 15% in animals pretreated with 1, 5, and 10 mu mol/L diazoxide (n = 8, n = 8, and n = 12, respectively) and 60 +/- 15% in the group treated with 5-HD+diazoxide (n = 5). Conclusions-The mitoK(ATP) channel opener diazoxide in vivo preserves neuronal function after I/R, shown by pial arteriolar responses to NMDA, in a dose-dependent manner. Thus, activation of mitoK(ATP) channels may play a role in mediating the protective effect of other K+ channel openers

Local stability implies global stability for the 2-dimensional Ricker map

Consider the difference equation $x_{k+1}=x_k e^{\alpha-x_{n-d}}$ where $\alpha$ is a positive parameter and d is a non-negative integer. The case d = 0 was introduced by W.E. Ricker in 1954. For the delayed version d >= 1 of the equation S. Levin and R. May conjectured in 1976 that local stability of the nontrivial equilibrium implies its global stability. Based on rigorous, computer aided calculations and analytical tools, we prove the conjecture for d = 1.Comment: for associated C++ program, mathematica worksheet and output, see http://www.math.u-szeged.hu/~krisztin/ricke

Nonequilibrium phase transition in a driven Potts model with friction

We consider magnetic friction between two systems of $q$-state Potts spins which are moving along their boundaries with a relative constant velocity $v$. Due to the interaction between the surface spins there is a permanent energy flow and the system is in a steady state which is far from equilibrium. The problem is treated analytically in the limit $v=\infty$ (in one dimension, as well as in two dimensions for large-$q$ values) and for $v$ and $q$ finite by Monte Carlo simulations in two dimensions. Exotic nonequilibrium phase transitions take place, the properties of which depend on the type of phase transition in equilibrium. When this latter transition is of first order, a sequence of second- and first-order nonequilibrium transitions can be observed when the interaction is varied.Comment: 13 pages, 9 figures, one journal reference adde

Cerebral Microcirculatory Responses of Insulin-Resistant Rats are Preserved to Physiological and Pharmacological Stimuli

AbstractWe study a programming language with a built-in ground type for real numbers. In order for the language to be sufficiently expressive but still sequential, we consider a construction proposed by Boehm and Cartwright. The non-deterministic nature of the construction suggests the use of powerdomains in order to obtain a denotational semantics for the language. We show that the construction cannot be modelled by the Plotkin or Smyth powerdomains, but that the Hoare powerdomain gives a computationally adequate semantics. As is well known, Hoare semantics can be used in order to establish partial correctness only. Since computations on the reals are infinite, one cannot decompose total correctness into the conjunction of partial correctness and termination as is traditionally done. We instead introduce a suitable operational notion of strong convergence and show that total correctness can be proved by establishing partial correctness (using denotational methods) and strong convergence (using operational methods). We illustrate the technique with a representative example

Scaling properties at the interface between different critical subsystems: The Ashkin-Teller model

We consider two critical semi-infinite subsystems with different critical exponents and couple them through their surfaces. The critical behavior at the interface, influenced by the critical fluctuations of the two subsystems, can be quite rich. In order to examine the various possibilities, we study a system composed of two coupled Ashkin-Teller models with different four-spin couplings epsilon, on the two sides of the junction. By varying epsilon, some bulk and surface critical exponents of the two subsystems are continuously modified, which in turn changes the interface critical behavior. In particular we study the marginal situation, for which magnetic critical exponents at the interface vary continuously with the strength of the interaction parameter. The behavior expected from scaling arguments is checked by DMRG calculations.Comment: 10 pages, 9 figures. Minor correction

Generalization gradients along the angularity dimension in pigeons following differential training with one or two salient features.

Dept. of Psychology. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1973 .F37. Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.A.)--University of Windsor (Canada), 1973

Lack of HIV testing and dissatisfaction with HIV testing and counselling among men having sex with men in Hungary.

Background: Using data from a large internet-based survey of European men having sex with men (MSM), we assessed factors associated with HIV testing and reasons for dissatisfaction with HIV testing and counselling among Hungarian MSM. Methods: A total of 2052 Hungarian MSM provided evaluable data for the European MSM Internet Survey (EMIS) in 2010. χ2 tests and Poisson regression with a robust variance estimator were used to assess factors associated with HIV testing and dissatisfaction with HIV testing and counselling. Results: A total of 42.1% of MSM reported never being testing for HIV. Over one-half of men (54.1%) who reported condomless anal intercourse (CAI) in the prior 12 months with a person of unknown or sero-discordant HIV status reported no lifetime HIV testing. The factor most strongly associated with dissatisfaction with HIV testing and counselling was test site with increased dissatisfaction with inpatient hospital settings vs. community-based organizations. Both lack of HIV testing and dissatisfaction with testing were independently associated with MSM who reported that no one, or only a few people, knew they were attracted to men. Conclusions: Lack of HIV testing was strongly associated with CAI. MSM reported that community-based organizations better supported confidentiality and were more respectful during HIV testing

Exotic complex Hadamard matrices, and their equivalence

In this paper we use a design theoretical approach to construct new, previously unknown complex Hadamard matrices. Our methods generalize and extend the earlier results of de la Harpe--Jones and Munemasa--Watatani and offer a theoretical explanation for the existence of some sporadic examples of complex Hadamard matrices in the existing literature. As it is increasingly difficult to distinguish inequivalent matrices from each other, we propose a new invariant, the fingerprint of complex Hadamard matrices. As a side result, we refute a conjecture of Koukouvinos et al. on (n-8)x(n-8) minors of real Hadamard matrices.Comment: 10 pages. To appear in Cryptography and Communications: Discrete Structures, Boolean Functions and Sequence