Global monitoring of ionospheric weather by GIRO and GNSS data fusion

Prompt and accurate imaging of the ionosphere is essential to space weather services, given a broad spectrum of applications that rely on ionospherically propagating radio signals. As the 3D spatial extent of the ionosphere is vast and covered only fragmentarily, data fusion is a strong candidate for solving imaging tasks. Data fusion has been used to blend models and observations for the integrated and consistent views of geosystems. In space weather scenarios, low latency of the sensor data availability is one of the strongest requirements that limits the selection of potential datasets for fusion. Since remote plasma sensing instrumentation for ionospheric weather is complex, scarce, and prone to unavoidable data noise, conventional 3D-var assimilative schemas are not optimal. We describe a novel substantially 4D data fusion service based on near-real-time data feeds from Global Ionosphere Radio Observatory (GIRO) and Global Navigation Satellite System (GNSS) called GAMBIT (Global Assimilative Model of the Bottomside Ionosphere with Topside estimate). GAMBIT operates with a few-minute latency, and it releases, among other data products, the anomaly maps of the effective slab thickness (EST) obtained by fusing GIRO and GNSS data. The anomaly EST mapping aids understanding of the vertical plasma restructuring during disturbed conditionsPeer ReviewedPostprint (published version

Influence of fly ash blending on hydration and physical behavior of Belite-Alite-Ye'elimite cements

A cement powder, composed of belite, alite and ye’elimite, was blended with 0, 15 and 30 wt% of fly ash and the resulting lended cements were further characterized. During hydration, the presence of fly ash caused the partial inhibition of both AFt degradation and belite reactivity, even after 180 days. The compressive strength of the corresponding mortars increased by increasing the fly ash content (68, 73 and 82 MPa for mortars with 0, 15 and 30 wt% of fly ash, respectively, at 180 curing days), mainly due to the diminishing porosity and pore size values. Although pozzolanic reaction has not been directly proved there are indirect evidences.This work is part of the Ph.D. of D. Londono-Zuluaga funded by Beca Colciencias 646—Doctorado en el exterior and Enlaza Mundos 2013 program grant. Cement and Building materials group (CEMATCO) from National University of Colombia is acknowledged for providing the calorimetric measurements. Funding from Spanish MINECO BIA2017-82391-R and I3 (IEDI-2016-0079) grants, co-funded by FEDER, are acknowledged

An integrated view of theiInfluence of temperature, pressure, and humidity on the stability of trimorphic cysteamine hydrochloride

Understanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after the incident with ritonavir. In the present paper, a comprehensive study of the solid-state phase behavior of cysteamine hydrochloride used in the treatment of nephropathic cystinosis and recently granted orphan designation by the European Commission is presented employing (high-pressure) calorimetry, water vapor sorption, and X-ray diffraction as a function of temperature. A new crystal form (I2/a, form III) has been discovered, and its structure has been solved by X-ray powder diffraction, while two other crystalline forms are already known. The relative thermodynamic stabilities of the commercial form I and of the newly discovered form III have been established; they possess an overall enantiotropic phase relationship, with form I stable at room temperature and form III stable above 37 degrees C. Its melting temperature was found at 67.3 +/- 0.5 degrees C. Cysteamine hydrochloride is hygroscopic and immediately forms a concentrated saturated solution in water with a surprisingly high concentration of 47.5 mol % above a relative humidity of 35%. No hydrate has been observed. A temperature composition phase diagram is presented that has been obtained with the unary pressure temperature phase diagram, measurements, and calculations. For development, form I would be the best form to use in any solid dosage form, which should be thoroughly protected against humidity.Postprint (author's final draft