Alien Registration- Conners, Michael W. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23895/thumbnail.jp

Nondestructive Evaluation of Hardwood Logs Using Automated Interpretation of CT Images

Knowledge of internal defects within hardwood logs can be useful even prior to a log’s entry into the sawmill. It is in the log yard where the first important decisions are made about processing. First, based upon perceived quality, logs may be sorted as veneer logs or as high-quality sawlogs and sold to domestic veneer mills or for export. Second, roundwood may be bucked into smaller logs to isolate defect areas and to obtain sawlogs with longer sections of clear wood. And third, logs containing metal objects can be identified, thereby preventing headrig saw damage and costly mill down-time

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

Differentiation of early gut endoderm cells into the endocrine cells forming the pancreatic islets of Langerhans depends on a cascade of gene activation events controlled by transcription factors including the basic helix-loop-helix (bHLH) proteins. To delineate this cascade, we began by establishing the position of neurogenin3, a bHLH factor found in the pancreas during fetal development. We detect neurogenin3 immunoreactivity transiently in scattered ductal cells in the fetal mouse pancreas, peaking at embryonic day 15.5. Although not detected in cells expressing islet hormones or the islet transcription factors Isl1, Brn4, Pax6 or PDX1, neurogenin3 is detected along with early islet differentiation factors Nkx6.1 and Nkx2.2, establishing that it is expressed in immature cells in the islet lineage. Analysis of transcription factor-deficient mice demonstrates that neurogenin3 expression is not dependent on neuroD1/BETA2, Mash1, Nkx2.2, Nkx6.1, or Pax6. Furthermore, early expression of neurogenin3 under control of the Pdx1 promoter is alone sufficient to drive early and ectopic differentiation of islet cells, a capability shared by the pancreatic bHLH factor, neuroD1/BETA2, but not by the muscle bHLH factor, MyoD. However, the islet cells produced in these transgenic experiments are overwhelmingly α cells, suggesting that factors other than the bHLH factors are required to deviate from a default α cell fate. These data support a model in which neurogenin3 acts upstream of other islet differentiation factors, initiating the differentiation of endocrine cells, but switching off prior to final differentiation. The ability to uniquely identify islet cell precursors by neurogenin3 expression allows us to determine the position of other islet transcription factors in the differentiation cascade and to propose a map for the islet cell differentiation pathway

Flight Research Using F100 Engine P680063 in the NASA F-15 Airplane

The value of flight research in developing and evaluating gas turbine engines is high. NASA Dryden Flight Research Center has been conducting flight research on propulsion systems for many years. The F100 engine has been tested in the NASA F-15 research airplane in the last three decades. One engine in particular, S/N P680063, has been used for the entire program and has been flown in many pioneering propulsion flight research activities. Included are detailed flight-to-ground facility tests; tests of the first production digital engine control system, the first active stall margin control system, the first performance-seeking control system; and the first use of computer-controlled engine thrust for emergency flight control. The flight research has been supplemented with altitude facility tests at key times. This paper presents a review of the tests of engine P680063, the F-15 airplanes in which it flew, and the role of the flight test in maturing propulsion technology

An Exploratory Study of Aquatic Walking on Symptoms and Functional Limitations in Persons with Knee Osteoarthritis: Part 1

This paper represents Part 1 of a study that explored the effects of an underwater treadmill (UT) walking program on pain and function in adults with knee osteoarthritis (KOA). The Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC), numerical rating scale (NRS), timed up-and-go (TUG), and 10-m walk were assessed in 6 adults (62.7 ±14.2 years) who participated in an 8-week (3x/wk) UT walking intervention based on the Arthritis Foundation’s Walk With Ease (WWE) program. Walking pace was self-selected, and walking duration of each session was increased from 10 to 45 minutes throughout the study. Knee pain and function were assessed pre-control (PRC), pre-intervention (PRI) and post-intervention (PST). NRS improved from PRC and PRI to PST (p = .03, d = .37). WOMAC subscale scores of pain, (d = .36); stiffness (d = .44); pain during daily activities (d = .41); and total scores (d = .42) improved (p \u3c .05) from PRC to PST. Self-selected walking speed increased concurrently with decreased knee pain (NRS) from PRI to PST. The results support the WWE as a model for an UT walking program for improving knee pain in KOA

Clinical guidance on pharmacotherapy for the treatment of attention-deficit hyperactivity disorder (ADHD) for people with intellectual disability.

INTRODUCTION: ADHD causes significant distress and functional impairment in multiple domains of daily life. Therefore, diagnosis and treatment are important to improve the quality of life of people. The pharmacotherapy for ADHD is well established but needs systematic evaluation in Intellectual Disability (ID) populations. AREAS COVERED: This paper reviews the ADHD pharmacological treatment in people with ID using the PRISMA guidance for scoping reviews to help identify the nature and strength of evidence. EXPERT OPINION: In the last 20 years, seven randomized controlled trials have evaluated pharmacotherapies for ADHD in people with ID; five looking at methylphenidate. Generally, studies were underpowered; all but two had less than 25 participants. Of the two larger trials one was single blinded and therefore open to bias. Only two used a parallel-group method, the remainder were mostly short crossover trials; not ideal when measuring behavioral and psychological parameters which are long standing. The remaining evidence is made up of observational studies. Methylphenidate and atomoxetine, particularly at higher doses, have shown clear benefits in people with ID. Most people with ID tolerated ADHD medications well. Benefits were seen in behavioral and/or cognitive domains. The evidence base is limited, though promising, for dexamfetamine, clonidine, and guanfacine

Propulsion Flight Research at NASA Dryden From 1967 to 1997

From 1967 to 1997, pioneering propulsion flight research activities have been conceived and conducted at the NASA Dryden Flight Research Center. Many of these programs have been flown jointly with the United States Department of Defense, industry, or the Federal Aviation Administration. Propulsion research has been conducted on the XB-70, F-111 A, F-111E, YF-12, JetStar, B-720, MD-11, F-15, F- 104, Highly Maneuverable Aircraft Technology, F-14, F/A-18, SR-71, and the hypersonic X-15 airplanes. Research studies have included inlet dynamics and control, in-flight thrust computation, integrated propulsion controls, inlet and boattail drag, wind tunnel-to-flight comparisons, digital engine controls, advanced engine control optimization algorithms, acoustics, antimisting kerosene, in-flight lift and drag, throttle response criteria, and thrust-vectoring vanes. A computer-controlled thrust system has been developed to land the F-15 and MD-11 airplanes without using any of the normal flight controls. An F-15 airplane has flown tests of axisymmetric thrust-vectoring nozzles. A linear aerospike rocket experiment has been developed and tested on the SR-71 airplane. This paper discusses some of the more unique flight programs, the results, lessons learned, and their impact on current technology

Flight Stability and Control and Performance Results from the Linear Aerospike SR-71 Experiment (LASRE)

The Linear Aerospike SR-71 Experiment (LASRE) is presently being conducted to test a 20-percent-scale version of the Linear Aerospike rocket engine. This rocket engine has been chosen to power the X-33 Single Stage to Orbit Technology Demonstrator Vehicle. The rocket engine was integrated into a lifting body configuration and mounted to the upper surface of an SR-71 aircraft. This paper presents stability and control results and performance results from the envelope expansion flight tests of the LASRE configuration up to Mach 1.8 and compares the results with wind tunnel predictions. Longitudinal stability and elevator control effectiveness were well-predicted from wind tunnel tests. Zero-lift pitching moment was mispredicted transonically. Directional stability, dihedral stability, and rudder effectiveness were overpredicted. The SR-71 handling qualities were never significantly impacted as a result of the missed predictions. Performance results confirmed the large amount of wind-tunnel-predicted transonic drag for the LASRE configuration. This drag increase made the performance of the vehicle so poor that acceleration through transonic Mach numbers could not be achieved on a hot day without depleting the available fuel