Evaluation of nutrition and physical activity of students in Gastronomic School in Białystok

Celem pracy była ocena sposobu żywienia i aktywności fizycznej uczniów Zespołu Szkół Gastronomicznych w Białymstoku. Kwestionariusz ankiety przeprowadzono w kwietniu w 2008 roku wśród 74 uczniów. Obliczono wartość energetyczną i zawartość głównych składników odżywczych diety i porównano je z normami. Diety uczniów zawierały prawidłową wartość energetyczną i zawartość białka, tłuszczów oraz węglowodanów. Umiarkowaną aktywnością fizyczną charakteryzowało się jedynie 58% dziewcząt i 61% chłopców. Badani uczniowie powinni skorygować sposób odżywiania i zwiększyć aktywność fizyczną.The aim of this study was to estimate nutrition and physical activity of students in Gastronomic School in Białystok. Questionnaire about nutrition and physical activity took on April 2008 in 74 students. The content of energy and main nutrition values were calculated and compared to the recommended values. Students diet included normal of energy, protein, fats and carbohydrates. Only 58% girls and 61% boys had intensive physical activity. Change of nutrition and moderate in physical activity is recommended for the students

Overexpression of epidermal growth factor receptor as a prognostic factor in colorectal cancer on the basis of the Allred scoring system

Marta Rokita,1 Rafal Stec,1 Lubomir Bodnar,1 Radoslaw Charkiewicz,2 Jan Korniluk,1 Marta Smoter,1 Marzena Cichowicz,3 Lech Chyczewski,4 Jacek Nikliński,2 Wojciech Kozłowski,3 Cezary Szczylik11Department of Oncology, Military Institute of Medicine, Central Teaching Hospital, Warsaw, Poland; 2Department of Clinical Molecular Biology, Medical University of Bialystok, Bialystok, Poland; 3Department of Pathology, Military Institute of the Health Services in Warsaw, Warsaw, Poland; 4Department of Clinical Pathology, Medical University of Bialystok, Bialystok, PolandBackground: Overexpression of epidermal growth factor receptor (EGFR) is found in many types of neoplasms. The aim of the study was to evaluate EGFR expression in colorectal cancer (CRC) specimens and to determine whether EGFR expression correlates with clinicopathological data and overall survival.Patients and methods: Tissue specimens from 181 consecutive CRC patients treated at the Military Institute of Medicine in 2006–2010 were collected and examined for EGFR expression, by immunohistochemistry staining. The staining intensity and percentage of cells with membranous EGFR expression were scored and then grouped according to the parameters of the Allred Scoring system. Cutoff values were subjected to further statistical analysis. Univariate tests and a multivariate Cox proportional hazards model were used in data analysis.Results: EGFR was overexpressed in 96 of 181 CRC specimens (53%). EGFR expression was not correlated with other clinicopathological variables. On univariate analysis, overexpression of EGFR, determined by PS (percentage score) (>3) and total score (sum of PS and intensity score) (>4), was associated with poor overall survival. On multivariate analysis, EGFR overexpression (PS > 3) was an independent adverse prognostic factor (hazard ratio [HR] 1.62; 95% confidence interval [CI]: 1.03–2.53). Elevated carcinoembryonic antigen (CEA) serum concentration before treatment, performance status (Word Health Organization [WHO]-2), and tumor localized in colon and liver metastases were also independent unfavorable prognostic factors.Conclusion: EGFR overexpression (PS > 3) in a CRC patient population was an independent adverse prognostic factor. Implementation of the Allred Scoring system criteria into clinical practice might facilitate treatment decisions in CRC patients.Keywords: expression, receptor, prognosis, cance

Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation

Funding: Novo Nordic Foundation, the International EU project ReproUnion, Sofus Carl Emil og Hustrus Fond, and the Foundation for Polish Science (FNP).Objective: To characterize ovarian follicles of girls and young women with Turner syndrome (TS) who underwent ovarian tissue cryopreservation (OTC). Design: Retrospective case-control study. Setting: University hospital. Patient(s): Fifteen girls and young women with TS aged 5-22 years at OTC were included, together with 42 control girls and young women aged 1-25 years who underwent OTC because of cancer. Intervention(s): None. Main Outcome Measure(s): Follicle density (follicles/mm(3)), morphology, and health were assessed in ovarian cortex biopsies from TS patients and compared with controls. Hormone concentrations were measured in serum and follicle fluids. Immature cumulus oocyte complexes were obtained and matured in vitro. Result(s): Follicles were found in 60% of the biopsies (9 of 15) from TS ovaries. In 78% of the ovaries (7 of 9) with follicles, the follicle density was within the 95% confidence interval of the control group. There was a high rate of abnormal follicle morphology. Six follicle-specific proteins were expressed similarly in TS and control ovaries. However, apoptosis and zona pellucida protein expression were found to be abnormal in TS. Turner syndrome follicle fluid from small antral follicles had lower concentrations of estrogen and testosterone and higher concentrations of antimullerian hormone than controls. Thirty-one cumulus oocyte complexes were collected from one patient and cultured for 48 hours in vitro, resulting in five metaphase II oocytes (maturation rate 16%, degeneration rate 19%). Conclusion(s): The benefits of OTC may be limited to a highly selected group of TS mosaic patients in whom a sizeable pool of normal follicles is present at OTC. (C) 2019 by American Society for Reproductive Medicine.PostprintPeer reviewe

FUTURE TRENDS IN PRODUCT/PROCESS INNOVATION

The approaches to support innovation in industry, including ICT tools, have experienced tremendous changes in last decades and are likely to be a subject of further evolution. Many research trends could be observed that are likely to provide new innovation approaches and effective means to support such new innovation processes. This paper provides an overview of some of the key trends in product/process innovation in industry. The emphasis is on new approaches for innovation that are already emerging and will find their wide application in industry. Special emphasis is made upon ICT as a key facilitator of the innovation process in future.Some of the issues presented in this paper are partly within the scope of the current RTD project LeanPPD (Lean product/process development) supported by the Commission of European Community, under NMP — Nanosciences, Nanotechnologies, Materials and new Production Technologies Programme under the contract NMP-2008-214090. Authors wish to acknowledge the other partners in the consortium as well as the European Commission by its financial support. This document does not represent the opinion of the European Community, and the European Community is not responsible for any use that might be made of its content.Peer reviewe