Cross-Dimensional Gestural Interaction Techniques for Hybrid Immersive Environments

We present a set of interaction techniques for a hybrid user interface that integrates existing 2D and 3D visualization and interaction devices. Our approach is built around one- and two-handed gestures that support the seamless transition of data between co-located 2D and 3D contexts. Our testbed environment combines a 2D multi-user, multi-touch, projection surface with 3D head-tracked, see-through, head-worn displays and 3D tracked gloves to form a multi-display augmented reality. We also address some of the ways in which we can interact with private data in a collaborative, heterogeneous workspace

An ultrastable silicon cavity in a continuously operating closed-cycle cryostat at 4 K

We report on a laser locked to a silicon cavity operating continuously at 4 K with $1 \times 10^{-16}$ instability and a median linewidth of 17 mHz at 1542 nm. This is a ten-fold improvement in short-term instability, and a $10^4$ improvement in linewidth, over previous sub-10 K systems. Operating at low temperatures reduces the thermal noise floor, and thus is advantageous toward reaching an instability of $10^{-18}$, a long-sought goal of the optical clock community. The performance of this system demonstrates the technical readiness for the development of the next generation of ultrastable lasers that operate with ultranarrow linewidth and long-term stability without user intervention.Comment: 5 pages, 4 figure

CoRoT 102749568: mode identification in a delta Scuti star based on regular spacings

The high accuracy of space data increased the number of the periodicities determined for pulsating variable stars, but the mode identification is still a critical point in the non-asymptotic regime. We use regularities in frequency spacings for identifying the pulsation modes of the recently discovered delta Sct star ID 102749568. In addition to analysing CoRoT light curves (15252 datapoints spanning 131 days), we obtained and analysed both spectroscopic and extended multi-colour photometric data. We applied standard tools (MUFRAN, Period04, SigSpec, and FAMIAS) for time-series analysis. A satisfactory light-curve fit was obtaining by means of 52 independent modes and 15 combination terms. The frequency spacing revealed distinct peaks around large (25.55-31.43 microHz), intermediate (9.80, 7.66 microHz), and low (2.35 microHz) separations. We directly identified 9 modes, and the l and n values of other three modes were extrapolated. The combined application of spectroscopy, multi-colour photometry, and modelling yielded the precise physical parameters and confirmed the observational mode identification. The large separation constrained the log g and related quantities. The dominant mode is the radial first overtone.Comment: 13 pages, 8 figures, accepted for publication in A&

Re-engage: A novel nurse-led program for survivors of childhood cancer who are disengaged from cancer-related care

Background: Survivors of childhood cancer often experience treatmentrelated chronic health conditions. Survivorship care improves survivors' physical and mental health, yet many are disengaged from care. Innovative models of care are necessary to overcome patient-reported barriers to accessing survivorship care and to maximize survivors' health. Methods:We piloted a novel survivorship program, called "Reengage,"a distance-delivered, nurse-led intervention aiming to engage, educate, and empower survivors not receiving any cancerrelated care. Re-engage involves a nurse-led consultation delivered via telephone/online to establish survivors' medical history and needs. Participants completed questionnaires at baseline, 1 month postintervention, and 6-month follow-up. Results: A total of 27 survivors who had not accessed survivorship care in the last 2 years participated (median age, 31 years; interquartile range [IQR], 27-39 years); of which, 82% were at high-risk for treatment-related complications. Participation in Re-engage was high (75%) and there was no attrition once survivors enrolled. At 1 month postintervention, 92% of survivors reported that Re-engage was "beneficial,"which all survivors reported at 6-month follow-up. Survivors' overall satisfaction with their care increased from 52% before Re-engage to 84% at 1 month postintervention. Survivors' mean self-efficacy scores remained similar from baseline to 1 month postintervention (b520.33, 95% CI, 21.31 to 0.65), but increased significantly from baseline to 6-month follow-up (b 5 1.64, 95% CI, 0.28-3.00). At 6-month follow-up, 73% of survivors showed an increase in health-related self-efficacy compared with baseline. Conclusions: Re-engage is a highly acceptable and feasible intervention and promotes health-related self-efficacy, which is integral to survivors being advocates for their own health. Further empirical work is needed to evaluate the long-term efficacy of Re-engage. Trial registration: ACTRN12618000194268

Multi-site campaign for transit timing variations of WASP-12 b: possible detection of a long-period signal of planetary origin

The transiting planet WASP-12 b was identified as a potential target for transit timing studies because a departure from a linear ephemeris was reported in the literature. Such deviations could be caused by an additional planet in the system. We attempt to confirm the existence of claimed variations in transit timing and interpret its origin. We organised a multi-site campaign to observe transits by WASP-12 b in three observing seasons, using 0.5-2.6-metre telescopes. We obtained 61 transit light curves, many of them with sub-millimagnitude precision. The simultaneous analysis of the best-quality datasets allowed us to obtain refined system parameters, which agree with values reported in previous studies. The residuals versus a linear ephemeris reveal a possible periodic signal that may be approximated by a sinusoid with an amplitude of 0.00068+/-0.00013 d and period of 500+/-20 orbital periods of WASP-12 b. The joint analysis of timing data and published radial velocity measurements results in a two-planet model which better explains observations than single-planet scenarios. We hypothesize that WASP-12 b might be not the only planet in the system and there might be the additional 0.1 M_Jup body on a 3.6-d eccentric orbit. A dynamical analysis indicates that the proposed two-planet system is stable over long timescales.Comment: Accepted for publication in A&

Clinical and Mucosal Immune Correlates of HIV-1 Semen Levels in Antiretroviral-Naive Men.

Background. This study was done to characterize parameters associated with semen human immunodeficiency virus (HIV)-1 ribonucleic acid (RNA) viral load (VL) variability in HIV-infected, therapy-naive men. Methods. Paired blood and semen samples were collected from 30 HIV-infected, therapy-naive men who have sex with men, and 13 participants were observed longitudinally for up to 1 year. Human immunodeficiency virus RNA, bacterial load by 16S RNA, herpesvirus (Epstein-Barr virus and cytomegalovirus [CMV]) shedding, and semen cytokines/chemokines were quantified, and semen T-cell subsets were assessed by multiparameter flow cytometry. Results. Semen HIV RNA was detected at 93% of visits, with \u3e50% of men shedding high levels of virus (defined as \u3e5000 copies/mL). In the baseline cross-sectional analysis, an increased semen HIV VL correlated with local CMV reactivation, the semen bacterial load, and semen inflammatory cytokines, particularly interleukin (IL)-8. T cells in semen were more activated than blood, and there was an increased frequency of Th17 cells and γδ-T-cells. Subsequent prospective analysis demonstrated striking interindividual variability in HIV and CMV shedding patterns, and only semen IL-8 levels and the blood VL were independently associated with semen HIV levels. Conclusions. Several clinical and immune parameters were associated with increased HIV semen levels in antiretroviral therapy-naive men, with induction of local proinflammatory cytokines potentially acting as a common pathway

Monitoring a high--amplitude Delta Sct star for 152 days: discovery of 12 additional modes and modulation effects in the light curve of CoRoT 101155310

The detection of small-amplitude nonradial modes in high-amplitude Delta Sct (HADS) variables has been very elusive until at least five of them were detected in the light curve of V974 Oph obtained from ground-based observations. The combination of radial and nonradial modes has a high asteroseismic potential, thanks to the strong constraints we can put in the modelling. The continuous monitoring of ASAS 192647-0030.0=CoRoT 101155310 (P=0.1258 d, V=13.4) ensured from space by the CoRoT (Convection, Rotation and planetary Transits) mission constitutes a unique opportunity to exploit such potential. The 22270 CoRoT measurements were performed in the chromatic mode. They span 152 d and cover 1208 consecutive cycles. After the correction for one jump and the long-term drift, the level of the noise turned out to be 29 micromag. The phase shifts and amplitude ratios of the coloured CoRoT data, the HARPS spectra, and the period-luminosity relation were used to determine a self-consistent physical model. In turn, it allowed us to model the oscillation spectrum, also giving feedback on the internal structure of the star. In addition to the fundamental radial mode f1=7.949 c/d with harmonics up to 10f1, we detected 12 independent terms. Linear combinations were also found and the light curve was solved by means of 61 frequencies (smallest amplitude 0.10 mmag). The newest result is the detection of a periodic modulation of the f1 mode (triplets at +/-0.193 c/d centred on f1 and 2f1), discussed as a rotational effect or as an extension of the Blazhko effect to HADS stars. The physical model suggests that CoRoT 101155310 is an evolved star, with a slight subsolar metallic abundance, close to the terminal age main sequence. All the 12 additional terms are identified with mixed modes in the predicted overstable region.Comment: 10 pages, 6 figures, Tables 1 and 2 available at CDS after publication. Accepted for publication in Astronomy and Astrophysic

The semen microbiome and its relationship with local immunology and viral load in HIV infection

Semen is a major vector for HIV transmission, but the semen HIV RNA viral load (VL) only correlates moderately with the blood VL. Viral shedding can be enhanced by genital infections and associated inflammation, but it can also occur in the absence of classical pathogens. Thus, we hypothesized that a dysregulated semen microbiome correlates with local HIV shedding. We analyzed semen samples from 49 men who have sex with men (MSM), including 22 HIV-uninfected and 27 HIV-infected men, at baseline and after starting antiretroviral therapy (ART) using 16S rRNA gene-based pyrosequencing and quantitative PCR. We studied the relationship of semen bacteria with HIV infection, semen cytokine levels, and semen VL by linear regression, non-metric multidimensional scaling, and goodness-of-fit test. Streptococcus, Corynebacterium, and Staphylococcus were common semen bacteria, irrespective of HIV status. While Ureaplasma was the more abundant Mollicutes in HIV-uninfected men, Mycoplasma dominated after HIV infection. HIV infection was associated with decreased semen microbiome diversity and richness, which were restored after six months of ART. In HIV-infected men, semen bacterial load correlated with seven pro-inflammatory semen cytokines, including IL-6 (p = 0.024), TNF-α (p = 0.009), and IL-1b (p = 0.002). IL-1b in particular was associated with semen VL (r(2)  = 0.18, p = 0.02). Semen bacterial load was also directly linked to the semen HIV VL (r(2) = 0.15, p = 0.02). HIV infection reshapes the relationship between semen bacteria and pro-inflammatory cytokines, and both are linked to semen VL, which supports a role of the semen microbiome in HIV sexual transmission