Constraints on the distance to SGR 1806-20 from HI absorption

The giant flare detected from the magnetar SGR 1806-20 on 2004 December 27 had a fluence more than 100 times higher than the only two other SGR flares ever recorded. Whereas the fluence is independent of distance, an estimate for the luminosity of the burst depends on the source's distance, which has previously been argued to be ~15 kpc. The burst produced a bright radio afterglow, against which Cameron et al. (2005) have measured an HI absorption spectrum. This has been used to propose a revised distance to SGR 1806-20 of between 6.4 and 9.8 kpc. Here we analyze this absorption spectrum, and compare it both to HI emission data from the Southern Galactic Plane Survey and to archival 12-CO survey data. We confirm ~6 kpc, as a likely lower limit on the distance to SGR 1806-20, but argue that it is difficult to place an upper limit on the distance to SGR 1806-20 from the HI data currently available. The previous value of ~15 kpc thus remains the best estimate of the distance to the source.Comment: 3 pages, 1 embedded EPS figure. Added sentences to end of Abstract and Conclusion, clarifying that most likely distance is 15 kpc. ApJ Letters, in pres

Mechanism of Single-Stranded DNA Activation of Recombinase Intein Splicing

Inteins, or intervening proteins, are mobile genetic elements translated within host polypeptides and removed through protein splicing. This self-catalyzed process breaks two peptide bonds and rejoins the flanking sequences, called N- and C-exteins, with the intein scarlessly escaping the host protein. As these elements have traditionally been viewed as purely selfish genetic elements, recent work has demonstrated that the conditional protein splicing (CPS) of several naturally occurring inteins can be regulated by a variety of environmental cues relevant to the survival of the host organism or crucial to the invading protein function. The RadA recombinase from the archaeon Pyrococcus horikoshii represents an intriguing example of CPS, whereby protein splicing is inhibited by interactions between the intein and host protein C-extein. Single-stranded DNA (ssDNA), a natural substrate of RadA as well as signal that recombinase activity is needed by the cell, dramatically improves the splicing rate and accuracy. Here, we investigate the mechanism by which ssDNA exhibits this influence and find that ssDNA strongly promotes a specific step of the splicing reaction, cyclization of the terminal asparagine of the intein. Interestingly, inhibitory interactions between the host protein and intein that block splicing localize to this asparagine, suggesting that ssDNA binding alleviates this inhibition to promote splicing. We also find that ssDNA directly influences the position of catalytic nucleophiles required for protein splicing, implying that ssDNA promotes assembly of the intein active site. This work advances our understanding of how ssDNA accelerates RadA splicing, providing important insights into this intriguing example of CPS

Systematic Review and Meta-Analysis of Preterm Birth and Later Systolic Blood Pressure

Lower birth weight because of fetal growth restriction is associated with higher blood pressure later in life, but the extent to which preterm birth ( <37 completed weeks' gestation) or very low birth weight ( <1500 g) predicts higher blood pressure is less clear. We performed a systematic review of 27 observational studies that compared the resting or ambulatory systolic blood pressure or diagnosis of hypertension among children, adolescents, and adults born preterm or very low birth weight with those born at term. We performed a meta-analysis with the subset of 10 studies that reported the resting systolic blood pressure difference in millimeters of mercury with 95% CIs or SEs. We assessed methodologic quality with a modified Newcastle-Ottawa Scale. The 10 studies were composed of 1342 preterm or very low birth weight and 1738 term participants from 8 countries. The mean gestational age at birth of the preterm participants was 30.2 weeks (range: 28.8-34.1 weeks), birth weight was 1280 g (range: 1098-1958 g), and age at systolic blood pressure measurement was 17.8 years (range: 6.3-22.4 years). Former preterm or very low birth weight infants had higher systolic blood pressure than term infants (pooled estimate: 2.5 mm Hg [95% CI: 1.7-3.3 mm Hg]). For the 5 highest quality studies, the systolic blood pressure difference was slightly greater, at 3.8 mm Hg (95% CI: 2.6-5.0 mm Hg). We conclude that infants who are born preterm or very low birth weight have modestly higher systolic blood pressure later in life and may be at increased risk for developing hypertension and its sequela

A Neutral Hydrogen Self-Absorption Cloud in the SGPS

Using data from the Southern Galactic Plane Survey (SGPS) we analyze an HI self-absorption cloud centered on l = 318.0 deg, b = -0.5 deg, and velocity, v = -1.1 km/s. The cloud was observed with the Australia Telescope Compact Array (ATCA) and the Parkes Radio Telescope, and is at a near kinematic distance of less than 400 pc with derived dimensions of less than 5 x 11 pc. We apply two different methods to find the optical depth and spin temperature. In both methods we find upper limit spin temperatures ranging from 20 K to 25 K and lower limit optical depths ~ 1. We look into the nature of the HI emission and find that 60-70% originates behind the cloud. We analyze a second cloud at the same velocity centered on l = 319 deg and b = 0.4 deg with an upper limit spin temperature of 20 K and a lower limit optical depth of 1.6. The similarities in spin temperature, optical depth, velocity, and spatial location are evidence the clouds are associated, possibly as one large cloud consisting of smaller clumps of gas. We compare HI emission data with 12CO emission and find a physical association of the HI self-absorption cloud with molecular gas.Comment: 33 pages, 17 figures, 5 tables; Accepted for publication in ApJ. A version with higher quality images availabe at http://www.astro.umn.edu/~dkavars/ms.p

Prepregnancy body mass index and risk of preterm birth: association heterogeneity by preterm subgroups

Background: To evaluate the association between prepregnancy body mass index (BMI) is associated with early vs. late and medically-induced vs. spontaneous preterm birth (PTB) subtypes. Methods: Using data from the Boston Birth Cohort, we examined associations of prepregnancy BMI with 189 early (<34 completed weeks) and 277 late (34–36 completed weeks) medically-induced PTBs and 320 early and 610 late spontaneous PTBs vs. 3281 term births (37–44 weeks) in multinomial regression. To assess for mediation by important pregnancy complications, we performed sequential models with and without hypertensive disorders of pregnancy, chorioamnionitis, and gestational diabetes. Results: Prevalence of prepregnancy obesity (BMI ≥ 30.0 kg/m2) was 28% among mothers with medically-induced PTBs, 18% among mothers with spontaneous PTBs, and 18% among mothers with term births (p = <0.001). After adjustment for demographic and known risk factors for PTB, prepregnancy obesity was associated with higher odds of both early [OR 1.78 (1.19, 2.66)] and late [OR 1.49 (1.09, 2.04)] medically-induced PTB. These effect estimates were attenuated with inclusion of hypertensive disorders of pregnancy and gestational diabetes. For spontaneous deliveries, prepregnancy obesity was associated with decreased odds of PTB (0.76 [0.58, 0.98]) and underweight was nearly associated with increased odds of PTB (1.46 [0.99, 2.16]). Conclusion: Prepregnancy obesity is associated with higher risk of medically-induced, but not spontaneous PTB. Hypertensive disorders of pregnancy and gestational diabetes appear to partially explain the association between prepregnancy obesity and early and late medically-induced PTB

Galactic Kinematics Towards the South Galactic Pole. First Results from the Yale-San Juan Southern Proper-Motion Program

The predictions from a Galactic Structure and Kinematic model code are compared to the color counts and absolute proper-motions derived from the Southern Proper-Motion survey covering more than 700 $\deg^2$ toward the South Galactic Pole in the range $9 < B_{\rm J} \le 19$. The theoretical assumptions and associated computational procedures, the geometry for the kinematic model, and the adopted parameters are presented in detail and compared to other Galactic Kinematic models of its kind. The data to which the model is compared consists of more than 30,000 randomly selected stars, and it is best fit by models with a solar peculiar motion of +5 km s$^{-1}$ in the V-component (pointing in the direction of Galactic rotation), a large LSR speed of 270 km s$^{-1}$, and a (disk) velocity ellipsoid that always points towards the Galactic center. The absolute proper-motions in the U-component indicate a solar peculiar motion of $11.0 \pm 1.5$ km s$^{-1}$, with no need for a local expansion or contraction term. The fainter absolute motions show an indication that the thick-disk must exhibit a rather steep velocity gradient of about -36 km s$^{-1}$ kpc$^{-1}$ with respect to the LSR. We are not able to set constraints on the overall rotation for the halo, nor on the thick-disk or halo velocity dispersions. Some substructure in the U & V proper-motions could be present in the brighter bins $10 < B_{\rm J} < 13$, and it might be indicative of (disk) moving groups.Comment: 24 double-column pages, 12 tables, AAS Latex macros v4.0, 19 B&W figures, 1 color figure. Accepted for publication on The Astronomical Journa

Southern Galactic Plane Survey Measurements of the Spatial Power Spectrum of Interstellar H I in the Inner Galaxy

Using data from the Southern Galactic Plane Survey we have measured the spatial power spectrum of the interstellar neutral atomic hydrogen in the fourth Galactic quadrant. This function shows the same power law behavior that has been found for H I in the second quadrant of the Milky Way and in the Magellanic Clouds, with the same slope. When we average over velocity intervals broader than the typical small-scale velocity dispersion, we find that the slope steepens, from approx. -3 to -4 for the warm gas, as predicted by theories of interstellar turbulence if the column density fluctuations are dominated by variations in the gas density on small spatial scales. The cool gas shows a different increase of slope, that suggests that it is in the regime of turbulence dominated by fluctuations in the velocity field. Overall, these results confirm that the small scale structure and motions in the neutral atomic medium are well described by a turbulent cascade of kinetic energy.Comment: 20 pages with 8 figures, LaTeX. Accepted by Ap. J. (scheduled for ApJ Vol. 561 num. 2, November 10, 2001

Response letter: Serological evidence confirms the presumed diagnosis of Zika virus congenital infection in infants with microcephaly and ocular findings

FAV, Recife, PE, BrazilHosp Olhos HOPE, Recife, PE, BrazilUniv Fed Sao Paulo UNIFESP, EPM, Dept Ophthalmol & Visual Sci, Sao Paulo, SP, BrazilInst Visiao, Sao Paulo, SP, BrazilHosp Barao de Lucena, Recife, PE, BrazilHUOC, Recife, PE, BrazilUniv Fed Sao Paulo UNIFESP, EPM, Dept Ophthalmol & Visual Sci, Sao Paulo, SP, BrazilWeb of Scienc

Elimination of a group II intron from a plastid gene causes a mutant phenotype

Group II introns are found in bacteria and cell organelles (plastids, mitochondria) and are thought to represent the evolutionary ancestors of spliceosomal introns. It is generally believed that group II introns are selfish genetic elements that do not have any function. Here, we have scrutinized this assumption by analyzing two group II introns that interrupt a plastid gene (ycf3) involved in photosystem assembly. Using stable transformation of the plastid genome, we have generated mutant plants that lack either intron 1 or intron 2 or both. Interestingly, the deletion of intron 1 caused a strong mutant phenotype. We show that the mutants are deficient in photosystem I and that this deficiency is directly related to impaired ycf3 function. We further show that, upon deletion of intron 1, the splicing of intron 2 is strongly inhibited. Our data demonstrate that (i) the loss of a group II intron is not necessarily phenotypically neutral and (ii) the splicing of one intron can depend on the presence of another