Measuring Fertility Responses to Policy Measures in the German Democratic Republic

Everywhere the advent of industrial society and correspondingly high incomes has been accompanied by a fall in births. If one could only explain the fall unambiguously policy measures to counter it could be readily devised. Unfortunately there are many explanations, and from each follows a different policy prescription. If the income derived from women's work in offices and industry has become so high that they cannot afford the time to have children, then payments from the State to cover what they lose through child raising will offset that. If the obstacle is the cost of clothing and educating children to present high standards, then family allowances will serve and be much less expensive than replacing women's salaries. But if the reason for couples holding back is the danger of divorce, where the children would be a handicap to the single parent for work and for remarriage, then state subsidy is not so obviously the answer. And if the obstacle to childbearing is a shift in the culture from a familistic to an individual orientation then perhaps no affordable amount of money will induce people to have children. One could go on this way. If parents do not have children because they cannot find living premises sufficiently large for them, then housing subsidies are the answer. Some "explanations" of the fall in fertility lead to simple policy solutions; others would seem not to be amenable to any kind of policy. The inability to distinguish among competing theories of the fall of fertility means that theory cannot by itself prescribe policy. To get around the inability to understand theoretically we have resort to data. The present paper presents empirical evidence that in fact policy can make a difference. In order to do that it had first to measure the difference between fertility in West Germany and Austria on the one hand and East Germany on the other. Statistics show clearly that year by year since 1976 when policy measures were introduced in East Germany births have been higher by about half a child each year. But suppose that was due to parents just having earlier whatever number of children they were to have anyway; if this were so the rise in annual rates would be only temporary, and would have only a trifling long term effect. The authors establish that the rise in the East German rate is not of this character. And they also show that such a rise did not occur in West Germany and Austria. The measures that produced the rise included generous maternity leave, plus subsequent paid leave for working mothers, interest free marriage loans whose repayment was partly canceled on the birth or children. By concentrating on third and later children some of the benefits would have more effect on fertility for a given total expenditure. Unfortunately neither the East German authorities nor this paper's authors were able to distinguish the effect of the various elements in a somewhat heterogeneous package of policy measures, but they do show unambiguously the effect of the package as a whole

Some Demographic Aspects of Aging in the German Democratic Republic

If people are going to live longer, then the community will have a larger proportion of old people. This is true, but only if other things remain the same, and especially if birth rates remain the same. Rising birth rates could counteract improved survival. In fact birth rates have fallen, in the GDR as in other industrialized countries, so to the survival effect is added a low birth rate effect, and the latter is the major component of aging as it is actually occurring. What aging has taken place so far, in the GDR as elsewhere in the industrialized world, is slight compared with what is expected to take place before the new century is much advanced. The relatively high births that followed World War II are now adults moving towards the middle working years, and aging will intensity in the future. The people born in the late 1940s and 1950s offer plentiful experienced labor, and that has always been a clear advantage for production. But when technology moves very rapidly experience may become inapplicable, and the question is then whether people at middle ages can unlearn what they know and develop new skills. If they are slow to do so the shortage of young people will seriously handicap production. This and allied questions are not directly addressed in the present paper, but it does provide the demographic framework for their analysis. The population problem, wherever there is one, shows itself as tendencies that will develop their acutest form in the future. That is why so much of demography is concerned with projections or forecasts. The prospects for industry with its presently aging labor force, the prospects for the overall efficiency of the economy when large numbers start to retire about 2015, the social as well as the economic consequences of an aging society, these are the issues that underly the considerations of this paper. It is an example of fruitful collaboration between IIASA and scholars of a member country

Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells

Up to 5% of untreated female Onchocerca volvulus filariae develop potentially fatal pleomorphic neoplasms, whose incidence is increased following ivermectin treatment. We studied the occurrence of 8 filarial proteins and of Wolbachia endobacteria in the tumor cells. Onchocercomas from patients, untreated and treated with antibiotics and anthelminthics, were examined by immunohistology. Neoplasms were diagnosed in 112 of 3587 female and in 2 of 1570 male O. volvulus. The following proteins and other compounds of O. volvulus were expressed in the cells of the neoplasms: glutathione S-transferase 1, lysosomal aspartic protease, cAMP-dependent protein kinase, alpha-enolase, aspartate aminotransferase, ankyrin E1, tropomyosin, heat shock protein 60, transforming growth factor-beta, and prostaglandin E2. These findings prove the filarial origin of the neoplasms and confirm the pleomorphism of the tumor cells. Signs indicating malignancy of the neoplasms are described. Wolbachia were observed in the hypodermis, oocytes, and embryos of tumor-harbouring filariae using antibodies against Wolbachia surface protein, Wolbachia HtrA-type serine protease, and Wolbachia aspartate aminotransferase. In contrast, Wolbachia were not found in the cells of the neoplasms. Further, neoplasm-containing worms were not observed after more than 10 months after the start of sufficient treatment with doxycycline or doxycycline plus ivermectin

Stable Magnetostatic Solitons in Yttrium Iron Garnet Film Waveguides for Tilted in-Plane Magnetic Fields

The possibility of nonlinear pulses generation in Yttrium Iron Garnet thin films for arbitrary direction between waveguide and applied static in-plane magnetic field is considered. Up to now only the cases of in-plane magnetic fields either perpendicular or parallel to waveguide direction have been studied both experimentally and theoretically. In the present paper it is shown that also for other angles (besides 0 or 90 degrees) between a waveguide and static in-plane magnetic field the stable bright or dark (depending on magnitude of magnetic field) solitons could be created.Comment: Phys. Rev. B (accepted, April 1, 2002

Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda)

Ectopic secondary lymph follicles emerge in patients with autoimmune or infectious diseases, e.g. in the synovium in rheumatoid arthritis or the skin in Borrelia burgdorferi infection, but ectopic localisations in the skin are rarely described for helminth infections. We investigated the cellular composition of secondary lymph follicles in subcutaneous nodules from eight patients with hyperreactive onchocerciasis (synonymous “localised” form or sowda) using immunohistology. CD3- and CD45RO-positive T cells and CD20-positive B cells were present in the mantle zone. The germinal centre was characterised by many B cells and CD35-positive follicular dendritic cells, which formed a network of attached IgE- and CD23-positive cells with the low-affinity IgE (epsilon) receptor. Few of the B cells were labelled for IgG1, IgG2 and IgG4, whereas in other zones of the nodule IgG1 was expressed by plasma cells and IgG1-coated dead microfilariae. B cells and few macrophages expressed the MHC class II molecule HLA-DR. Mature CD68-positive tingible body macrophages with phagocytosed leukocytes and CD57-positive lymphocytes occurred in the germinal centre. Macrophages in the germinal centre only weakly expressed alpha1-antichymotrypsin in contrast to macrophages in other zones of the onchocercoma. Furthermore, the multifunctional cytokine TGF-beta was only weakly expressed by macrophages and lymphocytes in the secondary follicles. Only few tryptase-positive mast cells, calprotectin-positive young macrophages, eosinophils and neutrophils occurred in the secondary follicles, although these cells were abundant in the onchocercomas. In conclusion, the ectopic secondary lymph follicles in onchocercomas and lymph nodes from hyperreactive onchocerciasis patients are equally composed

Thermodynamics of quantum Brownian motion with internal degrees of freedom: the role of entanglement in the strong-coupling quantum regime

We study the influence of entanglement on the relation between the statistical entropy of an open quantum system and the heat exchanged with a low temperature environment. A model of quantum Brownian motion of the Caldeira-Leggett type - for which a violation of the Clausius inequality has been stated by Th.M. Nieuwenhuizen and A.E. Allahverdyan [Phys. Rev. E 66, 036102 (2002)] - is reexamined and the results of the cited work are put into perspective. In order to address the problem from an information theoretical viewpoint a model of two coupled Brownian oscillators is formulated that can also be viewed as a continuum version of a two-qubit system. The influence of an additional internal coupling parameter on heat and entropy changes is described and the findings are compared to the case of a single Brownian particle.Comment: 10 pages, 11 figure

Great Sumatra Earthquake Registers on Electrostatic Sensor

Strong electrical signals that correspond to the Mw = 9.3 earthquake of 26 December 2004, which occurred at 0058:50.7 UTC off the west coast of northern Sumatra, Indonesia, were recorded by an electrostatic sensor (a device that detects short-term variations in Earth’s electrostatic fi eld) at a seismic station in Italy, which had been installed to study the infl uence of local earthquakes on a new landslide monitoring system. Electrical signals arrived at the station practically instantaneously and were detected up to several hours before the onset of the Sumatra earthquake (Figure 1) as well as before local quakes. The corresponding seismic signals (p-waves) arrived 740 seconds after the start of the earthquake. Because the electrical signals travel at the speed of light, electrical monitoring for the global detection of very strong earthquakes could be an important tool in signifi cantly increasing the hazard alert window

Detection of the Filarial Parasite Mansonella streptocerca in Skin Biopsies by a Nested Polymerase Chain Reaction-Based Assay

To differentiate the skin-dwelling filariae Mansonella streptocerca and Onchocerca volvulus, a nested polymerase chain reaction (PCR) assay was developed from small amounts of parasite material present in skin biopsies. One nonspecific and one specific pair of primers were used to amplify the 5S rDNA spacer region of M. streptocerca. Biopsies with different microfilaria densities obtained from 104 Ugandans living in an area endemic forM. streptocerca were tested using both the nested PCR assay and standard parasitologic assessment of microfilariae. All 82 samples from microfilaria carriers were positive when tested using the nested PCR assay. In addition, M. streptocerca DNA could be detected in 16 samples thought to be microfilaria negative. Furthermore, six days follow- ing ivermectin treatment, M. streptocerca DNA was found in 12 of 14 microfilaria-negative biopsies. Control skin samples from patients infected with O. volvulus were all negative in the nested PCR assay. This assay improves the diagnosis of M. streptocerca and will facilitate further epidemiologic studies

Obligatory symbiotic Wolbachia endobacteria are absent from Loa loa

BACKGROUND: Many filarial nematodes harbour Wolbachia endobacteria. These endobacteria are transmitted vertically from one generation to the next. In several filarial species that have been studied to date they are obligatory symbionts of their hosts. Elimination of the endobacteria by antibiotics interrupts the embryogenesis and hence the production of microfilariae. The medical implication of this being that the use of doxycycline for the treatment of human onchocerciasis and bancroftian filariasis leads to elimination of the Wolbachia and hence sterilisation of the female worms. Wolbachia play a role in the immunopathology of patients and may contribute to side effects seen after antifilarial chemotherapy. In several studies Wolbachia were not observed in Loa loa. Since these results have been doubted, and because of the medical significance, several independent methods were applied to search for Wolbachia in L. loa. METHODS: Loa loa and Onchocerca volvulus were studied by electron microscopy, histology with silver staining, and immunohistology using antibodies against WSP, Wolbachia aspartate aminotransferase, and heat shock protein 60. The results achieved with L. loa and O. volvulus were compared. Searching for Wolbachia, genes were amplified by PCR coding for the bacterial 16S rDNA, the FTSZ cell division protein, and WSP. RESULTS: No Wolbachia endobacteria were discovered by immunohistology in 13 male and 14 female L. loa worms and in numerous L. loa microfilariae. In contrast, endobacteria were found in large numbers in O. volvulus and 14 other filaria species. No intracellular bacteria were seen in electron micrographs of oocytes and young morulae of L. loa in contrast to O. volvulus. In agreement with these results, Wolbachia DNA was not detected by PCR in three male and six female L. loa worms and in two microfilariae samples of L. loa. CONCLUSIONS: Loa loa do not harbour obligatory symbiotic Wolbachia endobacteria in essential numbers to enable their efficient vertical transmission or to play a role in production of microfilariae. Exclusively, the filariae cause the immunopathology of loiasis is patients and the adverse side effects after antifilarial chemotherapy. Doxycycline cannot be used to cure loiais but it probably does not represent a risk for L. loa patients when administered to patients with co-infections of onchocerciasis