301 research outputs found
Ranging system which compares an object reflected component of a light beam to a reference component of the light beam
A system is described for measuring the distance to an object by comparing a first component of a light pulse that is reflected off the object with a second component of the light pulse that passes along a reference path of known length, which provides great accuracy with a relatively simple and rugged design. The reference path can be changed in precise steps so that it has an equivalent length approximately equal to the path length of the light pulse component that is reflected from the object. The resulting small difference in path lengths can be precisely determined by directing the light pulse components into opposite ends of a detector formed of a material that emits a second harmonic light output at the locations where the opposite going pulses past simultaneously across one another
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Elevated fetal steroidogenic activity in autism
Autism affects males more than females, giving rise to the idea that the influence of steroid hormones on early fetal brain development may be one important early biological risk factor. Utilizing the Danish Historic Birth Cohort and Danish Psychiatric Central Register, we identified all amniotic fluid samples of males born between 1993 and 1999 who later received ICD-10 (International Classification of Diseases, 10th Revision) diagnoses of autism, Asperger syndrome or PDD-NOS (pervasive developmental disorder not otherwise specified) (n=128) compared with matched typically developing controls. Concentration levels of Î4 sex steroids (progesterone, 17α-hydroxy-progesterone, androstenedione and testosterone) and cortisol were measured with liquid chromatography tandem mass spectrometry. All hormones were positively associated with each other and principal component analysis confirmed that one generalized latent steroidogenic factor was driving much of the variation in the data. The autism group showed elevations across all hormones on this latent generalized steroidogenic factor (Cohen's d=0.37, P=0.0009) and this elevation was uniform across ICD-10 diagnostic label. These results provide the first direct evidence of elevated fetal steroidogenic activity in autism. Such elevations may be important as epigenetic fetal programming mechanisms and may interact with other important pathophysiological factors in autism
MicroRNA-101 expression is associated with JAK2V617F activity and regulates JAK2/STAT5 signaling.
Philadelphia negative myeloproliferative neopl 28 asms (MPNs) are clonal haematological diseases characterized by excessive production of mature blood cells. Exome sequencing of patient samples have showed a relatively low degree genomic complexity for these diseases1. The majority of MPN patients carry somatic mutations in the JAK2 gene, with the JAK2V617F missense mutation being the most common in poly33
cythemia vera (PV, 95%) and essential thrombocythemia (ET, 60%) 2.FP was supported by Fondazione Umberto Veronesi, and Institute Pasteur - Fondazione Cenci Bolognetti
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A behavioral comparison of male and female adults with high functioning autism spectrum conditions
Autism spectrum conditions (ASC) affect more males than females in the general population. However, within ASC it is unclear if there are phenotypic sex differences. Testing for similarities and differences between the sexes is important not only for clinical assessment but also has implications for theories of typical sex differences and of autism. Using cognitive and behavioral measures, we investigated similarities and differences between the sexes in age- and IQ-matched adults with ASC (high-functioning autism or Asperger syndrome). Of the 83 (45 males and 38 females) participants, 62 (33 males and 29 females) met Autism Diagnostic Interview-Revised (ADI-R) cut-off criteria for autism in childhood and were included in all subsequent analyses. The severity of childhood core autism symptoms did not differ between the sexes. Males and females also did not differ in self-reported empathy, systemizing, anxiety, depression, and obsessive-compulsive traits/symptoms or mentalizing performance. However, adult females with ASC showed more lifetime sensory symptoms (pâ=â0.036), fewer current socio-communication difficulties (pâ=â0.001), and more self-reported autistic traits (pâ=â0.012) than males. In addition, females with ASC who also had developmental language delay had lower current performance IQ than those without developmental language delay (p<0.001), a pattern not seen in males. The absence of typical sex differences in empathizing-systemizing profiles within the autism spectrum confirms a prediction from the extreme male brain theory. Behavioral sex differences within ASC may also reflect different developmental mechanisms between males and females with ASC. We discuss the importance of the superficially better socio-communication ability in adult females with ASC in terms of why females with ASC may more often go under-recognized, and receive their diagnosis later, than males
Evaluating the GeoSnap 13-m Cut-Off HgCdTe Detector for mid-IR ground-based astronomy
New mid-infrared HgCdTe (MCT) detector arrays developed in collaboration with
Teledyne Imaging Sensors (TIS) have paved the way for improved 10-m
sensors for space- and ground-based observatories. Building on the successful
development of longwave HAWAII-2RGs for space missions such as NEO Surveyor, we
characterize the first 13-m GeoSnap detector manufactured to overcome the
challenges of high background rates inherent in ground-based mid-IR astronomy.
This test device merges the longwave HgCdTe photosensitive material with
Teledyne's 2048x2048 GeoSnap-18 (18-m pixel) focal plane module, which is
equipped with a capacitive transimpedance amplifier (CTIA) readout circuit
paired with an onboard 14-bit analog-to-digital converter (ADC). The final
assembly yields a mid-IR detector with high QE, fast readout (>85 Hz), large
well depth (>1.2 million electrons), and linear readout.
Longwave GeoSnap arrays would ideally be deployed on existing ground-based
telescopes as well as the next generation of extremely large telescopes. While
employing advanced adaptive optics (AO) along with state-of-the-art diffraction
suppression techniques, instruments utilizing these detectors could attain
background- and diffraction-limited imaging at inner working angles <10
, providing improved contrast-limited performance compared to JWST
MIRI while operating at comparable wavelengths. We describe the performance
characteristics of the 13-m GeoSnap array operating between 38-45K,
including quantum efficiency, well depth, linearity, gain, dark current, and
frequency-dependent (1/f) noise profile.Comment: 17 pages, 17 figures. Accepted for publication in special addition of
Astronomische Nachrichten / Astronomical Notes as a contribution to SDW202
Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohnâs disease
GD and AWW receive core funding support from the Scottish Governmentâs Rural and Environmental Science and Analytical Services (RESAS) Division. JW was funded by the Wellcome Trust [Grant No. 098051]. JVL is funded by MRC New Investigator Grant (MR/P002536/1) and ERC Starting Grant (715662). JK is funded by NIHR: II-OL-1116-10027, NIH: R01-CA204403-01A1, Horizon H2020: ITN GROWTH. Imperial Biomedical Research Centre, SAGES research grant. Infrastructure support for this research was provided by the NIHR Imperial biomedical Research Centre (BRC). Microbiota analyses were carried out using the Maxwell computer cluster at the University of Aberdeen. We thank the Illumina MiSeq team at the Wellcome Sanger Institute for their assistance. This work was partially described in the Ph.D. thesis of KD (Retrieved 2020, Pediatric inflammatory bowel disease Monitoring, nutrition and surgery, https://pure.uva.nl/ws/files/23176012/Thesis_complete_.pdf).Peer reviewedPublisher PD
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Solar Thermochemical Energy Storage Through Carbonation Cycles of SrCOâ/SrO Supported on SrZrOâ
Solar thermochemical energy storage has enormous potential for enabling cost-effective concentrated solar power (CSP). A thermochemical storage system based on a SrO/SrCOâ carbonation cycle offers the ability to store and release high temperature (â1200â°C) heat. The energy density of SrCOâ/SrO systems supported by zirconia-based sintering inhibitors was investigated for 15 cycles of exothermic carbonation at 1150â°C followed by decomposition at 1235â°C. A sample with 40â
wtâ% of SrO supported by yttria-stabilized zirconia (YSZ) shows good energy storage stability at 1450â
MJâmâ»Âł over fifteen cycles at the same cycling temperatures. After further testing over 45 cycles, a decrease in energy storage capacity to 1260â
MJâmâ»Âł is observed during the final cycle. The decrease is due to slowing carbonation kinetics, and the original value of energy density may be obtained by lengthening the carbonation steps.Keywords: energy storage, strontium oxide, concentrated solar power, reactive stabilit
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