140 research outputs found

    Economic feasibility of strontium-90 fueled heaters for use in cold regions

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    This study was conducted to conceptually design and obtain cost estimates for various radioisotope fueled heating systems for use in potential cold regions applications, and to determine the economic feasibility of radioisotope fueled heaters by comparing them to fuel oil systems. The applications have been identified and grouped, according to thermal output: (1) 1 kWt septic tank heaters, well-head heaters, heaters to assist operation of sewage lagoons, and (2) 7 or 12 kWt potable water system heaters. Potentially economic locations for these heaters are in remote Alaskan communities of 50 to 200 residents, where fuel oil prices and reliability requirements are high. Two basic conceptual heat designs were considered: a heat source and radiation shielding with no external heat transfer equipment, and a heat source and radiation shielding with external heat transfer equipment. Costs for both conceptual designs were estimated for heater sizes of 1 kWt, 7 kWt, and 12 kWt. The major costs were for the heat source and equipment. Radioisotope heaters were found to be much more expensive than fuel oil systems. The radioisotope fuel costs contribute 50 percent or more to the overall cost. Thus, an effective method to make a substantial reduction in radioisotope system cost would be to lower the Sr price from 10 cents/curie. It was concluded that radioisotope heaters will not be economically competitive with fuel oil systems unless one or more of the following situations occur: the price of strontium-90 is reduced below 10 cents/curie; fuel oil prices increase significantly; or for a particular application, the reliability or adaptability of a fuel oil system is unacceptable and a radioisotope system is satisfactory

    The role of Allee effect in modelling post resection recurrence of glioblastoma

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    Resection of the bulk of a tumour often cannot eliminate all cancer cells, due to their infiltration into the surrounding healthy tissue. This may lead to recurrence of the tumour at a later time. We use a reaction-diffusion equation based model of tumour growth to investigate how the invasion front is delayed by resection, and how this depends on the density and behaviour of the remaining cancer cells. We show that the delay time is highly sensitive to qualitative details of the proliferation dynamics of the cancer cell population. The typically assumed logistic type proliferation leads to unrealistic results, predicting immediate recurrence. We find that in glioblastoma cell cultures the cell proliferation rate is an increasing function of the density at small cell densities. Our analysis suggests that cooperative behaviour of cancer cells, analogous to the Allee effect in ecology, can play a critical role in determining the time until tumour recurrence
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