HYAL1 (hyaluronoglucosaminidase 1)

Review on HYAL1 (hyaluronoglucosaminidase 1), with data on DNA, on the protein encoded, and where the gene is implicated

Non-Enzymatic Decomposition of Collagen Fibers by a Biglycan Antibody and a Plausible Mechanism for Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory and destructive joint disorder that affects tens of millions of people worldwide. Normal healthy joints maintain a balance between the synthesis of extracellular matrix (ECM) molecules and the proteolytic degradation of damaged ones. In the case of RA, this balance is shifted toward matrix destruction due to increased production of cleavage enzymes and the presence of (autoimmune) immunoglobulins resulting from an inflammation induced immune response. Herein we demonstrate that a polyclonal antibody against the proteoglycan biglycan (BG) causes tissue destruction that may be analogous to that of RA affected tissues. The effect of the antibody is more potent than harsh chemical and/or enzymatic treatments designed to mimic arthritis-like fibril de-polymerization. In RA cases, the immune response to inflammation causes synovial fibroblasts, monocytes and macrophages to produce cytokines and secrete matrix remodeling enzymes, whereas B cells are stimulated to produce immunoglobulins. The specific antigen that causes the RA immune response has not yet been identified, although possible candidates have been proposed, including collagen types I and II, and proteoglycans (PG's) such as biglycan. We speculate that the initiation of RA associated tissue destruction in vivo may involve a similar non-enzymatic decomposition of collagen fibrils via the immunoglobulins themselves that we observe here ex vivo

TIMP2 (TIMP metallopeptidase inhibitor 2)

Review on TIMP2 (TIMP metallopeptidase inhibitor 2), with data on DNA, on the protein encoded, and where the gene is implicated

Rationalization of the activity of medical ozone on intervertebral disc - A histological and biochemical study

Ozonetherapy is used for the treatment of immunodeficiency syndromes as well as for the treatment of cardiovascular disease. It is also used for the treatment of low back-pain with promising results although it is not yet well established. The aim of the current study is the presentation of the effects of ozonetherapy injected intradiscally or paravertebrally. We present the histological, immunological and biochemical changes in vertebral discs. Our material consist of human specimens as well as New Zealand rabbits

Head and neck: Laryngeal tumors: an overview

Review on Head and neck: Laryngeal tumors: an overview, with data on clinics, and the genes involved

Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transition.

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