Performance Analysis of Multiple Access Techniques for LTE system under Symbol Error Rate (SER) Calculation

In the recent years, so many technologies in multiple access trends have influenced the field of Wireless Sensor Networks in significant ways. Various trends are readily available technology of ubiquitous wireless sensor networks as well as wireless communication networks and progress in the development of two multiple access techniques are compared in this scenario: the OFDMA and SC-FDMA. The OFDMA and SC-FDMA transceivers are modeled and simulated considering both the interleaved and localized subcarriers mapping schemes. WSNs have the potentiality to connect the physical world with the virtual world by forming a network of sensor nodes. To prolong the networklsquo;s hop in terms of single and two hop using both techniques should be used in the sensor nodes. The minimization of computing and storage platforms as well as the development of novel micro sensors and sensor materials with high reliability force encourages technology in research on WSN. In this paper, we will proposed the field of multipath routing in wireless sensor networks, and mainly focus on the technology of SER of WSNs

Literature Survey of Security Enhancement in MANET Routing Protocols of WLANs

A Mobile Ad-hoc Network (MANET) is an autonomous collection of mobile users that communicate over relatively bandwidth constrained wireless links. One of the main issues in such networks is performance- in a dynamically changing topology; the nodes are expected to be power-aware due to the bandwidth constrained network. Another issue in such networks is security - since every node participates in the operation of the network equally, Malicious nodes are difficult to detect. There are several applications of mobile ad hoc networks such as disaster recovery operations, battle field communications, etc. The most active research area under MANET routing protocol is security. MANETs have certain unique characteristics that make them vulnerable to several types of attacks. Since they are deployed an open environment where all nodes co-operate in forwarding the packets in the network, Malicious nodes are difficult to detect

AN OVERVIEW OF VISCOSUPPLEMENTS: THERAPEUTIC MODALITY FOR THE AILMENT OF OSTEOARTHRITIS

Osteoarthritis is a multifarious joint disease and is caused by inflammatory mediators, along with a procedure of wear and tear of cartilage. Osteoarthritis outcome in cartilage degradation, synovial inflammation, subchondral bone eburnation, degeneration of menisci, and capsular hypertrophy, which takes part in the pathogenesis of Osteoarthritis. Pain is the leading symptom of Osteoarthritis. However the precise mechanism causing pain is multifactorial and is still not well known. Viscosupplementation with intraarticular hylauronic acid promotes chondrocyte hyaluronic acid synthesis and prevents the additional cartilage degradation and may possible help to promote the cartilage regeneration. It is also postulated to diminish the production of inflammatory mediators and matrix metalloproteinase involved in Osteoarthritis. Viscosupplementation decline osteoarthritis symptoms in early to judicious Osteoarthritis, and improves functional outcome, if other conservative treatment modalities are ineffective. Hyaluronic acid (HA) is the major constituent of a 1-­â€2μm layer on the surface of articular cartilage; it is also a major constituent of synovial fluid. HA has many properties including exerting an anti-inflammatory effect, it acts as a lubricant when movements in the joint are slow and as a shock absorber when movements are fast effect. Viscosupplementation relieves the symptoms of osteoarthritis of the knee, and this therapeutic effect may last several weeks. However, it is apparently not much greater than that of placebo and, according to some studies, it barely reaches clinical significance. Its pain-relieving effect seems comparable to that of other non-surgical options. The modest clinical benefit of viscosupplementation may never be great enough to outweigh its disadvantages, which include slow onset of action, the need for several weekly injections, the low but present risk of adverse reactions and the relatively high cost of this treatment. It helps in improving the function in early osteoarthritis knee joint and might delay the need for future knee surgery Keywords: Joint disorders, intraarticular hylauronic acid, non-steroidal anti-inflammatory drugs, osteoarthritisÂ

A COMPARATIVE STUDY OF STEREOCHEMICAL EFFECTS OF ANTI-PROSTATE AGENTS BY MOLECULAR DOCKING

Objective: A comparative study of anti-prostate agents to investigate the stereochemical influences on binding affinity by molecular docking.Methods: Structures of enantiomers (R and S stereoisomers) for known anti-prostate cancer (PCa) agents were drawn using ChemBioDraw 2D software. Thereafter, they were converted to 3D structures using the ChemBioDraw 3D software in which they were subjected to energy minimization using the MM2 method and then saved as PDB extension files which can be accessed using the ADT interface. AutoDock Vina (ADT) 1.5.6 software version was used for molecular docking study.Results: A total of 12 different anti-PCa agents were selected and drawn including well-known drug R-bicalutamide. All molecules showed the binding affinity with respect to the nature of stereochemistry. R-stereoisomers showed better interaction as well as binding affinity toward 1z95 (mutated androgen receptor protein involved in the progression of PCa) whereas their S-stereoisomers were found inferior in comparison.Conclusion: This study showed that CB1-R and R-bicalutamide (with R-stereochemistry) were better in binding affinity comparative to their counterpart CB1-S and S-Bicalutamide (with S-stereochemistry). All the selected anti-PCa agents were showing the effect of stereochemical center; therefore, we must choose the right kind of stereochemistry while planning to develop the newer anti-PCa agents

Preclinical evaluation of a novel abluminal surface coated sirolimus eluting stent with biodegradable polymer matrix

BACKGROUND: Second generation of drug eluting stents (DES) has attempted to improve safety using abluminal sirolimus drug delivery with biodegradable polymers matrix. The present preclinical study was designed to investigate the safety and efficacy profile of Abluminus™ stents (SES). This is a new coronary stent with sirolimus and biodegradable polymer matrix coated on abluminal stent and balloon surface. METHODS: SES were compared with two controls: bare metal stent (BMS) and BMS + polymer coated stents (PC). All devices (40 stents) were implanted in porcine coronary arteries with primary endpoint of endothelialization at 7 days and subsequent histological and morphometric evaluations at 7, 30 and 90 days. RESULTS: Early endothelialization at seven days was complete in all stents. Histology at 30 days revealed minimum inflammation in all groups and increased at 90 days in PC group while it was absent at 180 days. Thirty day morphometry showed significantly reduction of neointimal area in Abluminus™ (SES 0.96±0.48 mm(2); BMS 1.83±0.34 mm(2); PC 1.76±0.55 mm(2); P<0.05); after 90 days neointimal area was 1.10±0.54 mm(2) for SES; 1.92±0.36 mm(2) for BMS; and 1.94±0.48 mm(2) for PC; P<0.05). Neointimal thickness at 30 and 90 days respectively was 0.15±0.07 and 0.18±0.10 mm for SES, 0.57±0.08 and 0.61±0.09 mm for BMS and 0.52±0.09 and 0.59±0.08 mm, P<0.001 for PC group. CONCLUSIONS: The most significant experimental evidence appears to be earlier endothelialization at 7 days for SES which led to safety of the device. Efficacy of the device was also observed by a reduced neointimal thickness and minimized inflammatory score at all follow-ups. Termination of antiplatelet at 30 days has not shown any further complications. Polymer thickness was almost in negligible amount at 180 days with no inflammation

ENRICHMENT OF MEMORY BY USING HERBAL FORMULATIONS

Memory is the ability of an organism to store, retain, and subsequently recall information. Memory enhancers are the compounds which improve or enhance the memory. The compounds, enhance memory are called nootropics. Some physiological conditions such as stress, anxiety affect the memory. Memory loss may be age related and due to some disease condition like Alzheimer’s disease, Parkinson’s disease etc. There are several nootropics marketed such as torental, duxil but these products has side effects like vascular dementia related to lacunae or to multiple infarcts, or leucoaraiosis and drg related amnesia. So mostly people prefer herbal nootropics over synthetic nootropics because they have less side effects than others. Herbal nootrppics mainly act by different ways like by increasing and replenishing neurotransmitter at high concentration in brain, by anti-depression, adaptogenic and mood stabilization, by improved oxygen supply and brain energy, by improved concentration, stamina, and focus, by memory enhancement and learning improvement, by nerve growth stimulation and brain cell protection. Memory is the most imperative characteristic for effectual survival of human beings. It also differentiates humans from animals. Reminiscence is the ability of an personage to record the in sequence and recall it whenever needed. Traditionally herbal drugs have been used to augment cognitive functions. A figure of medicinal plants and medicines derived from these plants have shown memory enhancing properties by virtue of their medicinal constituents. There has been substantial pharmacological exploration into the memory enhancing activity of some compounds. Since allopathic system of medicine is yet to make available a radical cure, the usefulness of traditional medicines needs to be explored. This article reviews the memory enhancing properties of the most commonly employed herbal medicines and their identified active constituents. The herbs acting on the brain are called Nootropic herbs and their isolated constituents are referred to as smart drugs. These herbs enhance the memory as well as increase blood circulation in the brain

In-silico molecular docking for Potential herbal leads from Withaniasomnifera L. Dunal for the treatment of Alzheimer’s disease

Alzheimer's disease (AD) poses a significant global health challenge, necessitating novel therapeutic interventions. Withaniasomnifera L. Dunal, commonly known as Ashwagandha, has been historically utilized in traditional medicine for its neuroprotective properties. This study employs computational techniques to explore the potential of W. somnifera compounds in targeting key proteins associated with AD. The reported phytoconstituents of W. somnifera were identified and subjected to molecular docking studies against 5NUU (Torpedo californica acetylcholinesterase in complex with a chlorotacrine-tryptophan hybrid inhibitor), as crucial targets. The results revealed several phytoconstituents of W. somnifera exhibiting favorable binding affinities and promising interactions with the target proteins. These findings provide a valuable foundation for further experimental validation and the development of novel therapeutic agents derived from natural sources for the treatment of Alzheimer's