The Topology of Foliations Formed by the Generic K-Orbits of a Subclass of the Indecomposable MD5-Groups

The present paper is a continuation of [13], [14] of the authors. Specifically, the paper considers the MD5-foliations associated to connected and simply connected MD5-groups such that their Lie algebras have 4-dimensional commutative derived ideal. In the paper, we give the topological classification of all considered MD5-foliations. A description of these foliations by certain fibrations or suitable actions of $\mathbb{R}^{2}$ and the Connes' C*-algebras of the foliations which come from fibrations are also given in the paper.Comment: 20 pages, no figur

Age-related changes in prefrontal and hippocampal contributions to relational encoding

Age-related declines in relational encoding are well documented. It remains unclear, however, whether such declines reflect dysfunction of (1) ventrolateral prefrontal cortex (VLPFC) and deficient generation of associations; and/or (2) hippocampal dysfunction and impoverished binding of associations. In order to separate VLPFC and hippocampal contributions to relational encoding, we manipulated the generative demands of the encoding task by varying the number of semantic associations between the to-be-encoded information (three words). Thus, trials with fewer semantic associations (lower-association trials) require more generative processing during encoding, relative to trials in which more semantic associations are provided for binding (higher-association trials). Parametric modulation analyses on successfully encoded items revealed that, unlike younger adults, older adults did not show an up-regulation of VLPFC activity during lower-association trials. In contrast, hippocampal activity in both older and younger adults was greater in higher- relative to lower-association trials. Moreover, recognition accuracy improved significantly in both groups with the provision of more semantic associations, indicating the both younger and older adults benefitted from this form of encoding support. Our findings suggest that left VLPFC dysfunction may underlie relational encoding deficits in older adults, but that when provided with associations to bind, hippocampal activity in older adults is comparable to young, consistent with their increased recognition accuracy under conditions of encoding support

Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang, Vietnam.

BACKGROUND: Acute respiratory infections (ARIs) are the most common causes of death in children under 5 years of age. While the etiology of most pneumonia and ARI episodes is undiagnosed, a broad range of ARI-causing viruses circulate widely in South East Asia. However, the patterns and drivers of the seasonal transmission dynamics are largely unknown. Here we identify the seasonal patterns of multiple circulating viruses associated with hospitalizations for ARIs in Nha Trang, Vietnam. METHODS: Hospital based enhanced surveillance of childhood ARI is ongoing at Khanh Hoa General Hospital in Nha Trang. RT-PCR was performed to detect 13 respiratory viruses in nasopharyngeal samples from enrolled patients. Seasonal patterns of childhood ARI hospital admissions of various viruses were assessed, as well as their association with rainfall, temperature, and dew point. RESULTS: Respiratory syncytial virus peaks in the late summer months, and influenza A in April to June. We find significant associations between detection of human parainfluenza 3 and human rhinovirus with the month's mean dew point. Using a cross-wavelet transform we find a significant out-of-phase relationship between human parainfluenza 3 and temperature and dew point. CONCLUSIONS: Our results are important for understanding the temporal risk associated with circulating pathogens in Southern Central Vietnam. Specifically, our results can inform timing of routing seasonal influenza vaccination and for when observed respiratory illness is likely viral, leading to judicious use of antibiotics in the region

Real time inverse kinematics of a general 5-axis CNC machine

In most of the previous investigations, the kinematics model of five-axis computer-numerical control (CNC) centers was formulated just at the position level, and the differential kinematic relationships (velocity, acceleration and jerk of the five joints of a five-axis center) that are necessary for several purposes, especially for investigating the relationship between the limits of a machine’s drives and the feed rate maximization (the productivity maximization), have been overlooked. Therefore, this paper addresses the differential kinematic modelling and analysis for the five-axis CNC centers. In particular, the differential kinematic equations are formulated in a parametric domain so that they are useful for investigating the kinematic behaviors of the five-axis centers in real time

23:1 Bandwidth ratio quasi‐lumped component balun on a multilayer organic substrate

In this study, the authors present the design and development of a novel ultra-wideband coupled-line balun on a multilayer liquid crystal polymer substrate. The balun is designed using a quarter wavelength (λ/4) asymmetric broadside coupled line. The defected ground structure and a lumped phase compensation circuit are developed to achieve wide bandwidth performance for the balun. The balun has a measured bandwidth ratio of 23:1, from 80 to 1860 MHz. Within the operating bandwidth, the experimental results demonstrate that the balun achieves an input return loss of better than 10 dB, an insertion loss of better than 1 dB, an amplitude imbalance of better than ±0.4 dB and a phase imbalance of better than ±10°. The size of the balun is 40.64 mm × 40.64 mm or 0.22 λg × 0.22 λg, where λg is the guided wavelength at the centre frequency of 970 MHz

ОПРЕДЕЛЕНИЕ ВИДОВОГО СОСТАВА АНТОЦИАНОВ ЦВЕТКОВ Сatharanthus

Using the reversed phase high performance liquid chromatography with diode-array and mass-spectrometric (in ESI mode) detection, a composition of Catharanthus roseum petals was established. After the acid hydrolysis, all five anthocyanidins were found to be different comparing to the ordinary anthocyanidins from Vitis vinifera fruits. The anthocyanins were elucidated to be 7-O-methyl derivatives of delphinidin, cyanidin, petunidin, peonidin and malvidin by the analysis of retention in RP HPLC, mass- and UV-visible spectra. The anthocyanins were characterized with UV-visible spectra, having the same fixtures as the set of non-methylated (in position 7) anthocyanin with hypsochromic (4 nm) of spectral maxima. The absorption bands for 7-methlcyanidin and 7-methylpeonidin aglycons and derivatives were indistinguishable while for the set of 7-methydelphinidin, 7-methypetunidin and 7-methylnalvidin (hirsutidin) a consecutive shift of absorption maxima by approximately 1 – 1.5 nm was found. The same was true for non-methylates at position 7 derivatives. The analysis of retention of anthocyanins of the flowers including the comparison with the retention of Mangifera indica skin anthocyanins, mass- and UV-visible spectra indicated that a minor set of anthocyanins included two sets of derivatives. The minor compounds were found to be 3-galactosides for samples under investigation, while the set of the major anthocyanins was represented by 3-rhamnosilgalactosides. Indeed, though through mass-spectra it was not possible to differentiate 3-rhamnosylgalatosides and 3-(p-coumaroylgalactosides) because of m/z coincidence, the retention difference between the two found anthocyanins sets as well as UV-visible spectra excluded the latter type of derivatives.Key words: anthocyanins, HPLC, 7-O-methyl derivatives of delphinidin, cyanidin, petunidin, peonidin and malvidin, 3-galactosides, 3-phamnosylgalactosides, UV-vis spectra, mass-spectrometric detection.(Russian)DOI: http://dx.doi.org/10.15826/analitika.2019.23.1.001V.I. Deineka1, Y.Y. Kulchenko1, А.N. Sidorov1, I.P. Blinova1, S.М. Varushkina1, L.А. Deineka1, Anh Thi Ngoc Vu2 1Belgorod National Research University, Pobeda str., 85, Belgorod, 308015,Russian Federation2 RUDN University, Miklukho-Maklaya str. 6, Moscow, 117198, Russian FederationС использованием обращенно-фазовой высокоэффективной жидкостной хроматографии с диодно-матричным и масс-спектрометрическим детектированием исследован видовой состав антоцианов цветков Catharanthus roseum. После кислотного гидролиза антоцианов по характерному изменению электронных спектров поглощения и по изменению удерживания было установлено, что все пять антоцианидинов цветков фиолетового цвета отличаются от пяти наиболее часто встречающихся в природе (в виде гликозидов) антоцианидинов однотипным дополнительным метилированием. Направление метилирования по гидроксильной группе в положении 7 флавилиевого скелета было определено при анализе изменения параметров электронных спектров поглощения; таким образом, антоцианы цветков катарантуса построены на пяти необычных антоцианидинах, – являясь производными 7-метилдельфинидина, 7-метилцианидина, 7-метилпетунидина, 7 метилпеонидина (розинидина) и 7 метилмальвидина (хирсутидина). Сопоставление масс-спектрометрических данных, электронных спектров поглощения и параметров удерживания антоцианов цветков Catharanthus roseum указывают на присутствие в экстрактах лепестках цветков 3-рамозилгалактозидов указанных антоцианидинов, к которым добавляются (в меньшем количестве) 3-галактозиды.Ключевые слова: антоцианы, 7-метилированные антоцианы, обращенно-фазовая ВЭЖХDOI: http://dx.doi.org/10.15826/analitika.2019.23.1.00

Population density, water supply, and the risk of dengue fever in Vietnam: cohort study and spatial analysis.

BACKGROUND: Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We analysed the interaction between human population density and lack of tap water as a cause of dengue fever outbreaks with the aim of identifying geographic areas at highest risk. METHODS AND FINDINGS: We conducted an individual-level cohort study in a population of 75,000 geo-referenced households in Vietnam over the course of two epidemics, on the basis of dengue hospital admissions (n = 3,013). We applied space-time scan statistics and mathematical models to confirm the findings. We identified a surprisingly narrow range of critical human population densities between around 3,000 to 7,000 people/km² prone to dengue outbreaks. In the study area, this population density was typical of villages and some peri-urban areas. Scan statistics showed that areas with a high population density or adequate water supply did not experience severe outbreaks. The risk of dengue was higher in rural than in urban areas, largely explained by lack of piped water supply, and in human population densities more often falling within the critical range. Mathematical modeling suggests that simple assumptions regarding area-level vector/host ratios may explain the occurrence of outbreaks. CONCLUSIONS: Rural areas may contribute at least as much to the dissemination of dengue fever as cities. Improving water supply and vector control in areas with a human population density critical for dengue transmission could increase the efficiency of control efforts. Please see later in the article for the Editors' Summary

Host Transcription Profile in Nasal Epithelium and Whole Blood of Hospitalized Children Under 2 Years of Age With Respiratory Syncytial Virus Infection.

BACKGROUND: Most insights into the cascade of immune events after acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. METHODS: In this study, we investigated host gene expression profiles in nasopharyngeal (NP) swabs and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalized patients <2 years old with lower respiratory tract infections. RESULTS: Respiratory syncytial virus infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments. Interferon-α/β, NOTCH1 signaling pathways and potential biomarkers HIST1H4E, IL7R, ISG15 in NP samples, or BCL6, HIST2H2AC, CCNA1 in blood are leading pathways and hub genes that were associated with both RSV load and severity. The observed RSV-induced gene expression patterns did not differ significantly in NP swab and blood specimens. In contrast, hRV infection did not as strongly induce expression of innate immunity pathways, and significant differences were observed between NP swab and blood specimens. CONCLUSIONS: We conclude that RSV induced strong and persistent innate immune responses and that RSV severity may be related to development of T follicular helper cells and antiviral inflammatory sequelae derived from high activation of BCL6