Development of a model for the optimization of pollutant emission generated in the process of combustion and detonation of ordnance

Моделовање загађења животне средине и негативног утицаја уништавања убојних средстава на истеку животног циклуса и активирања услед акцидента, извршена применом методе упоредне нумеричке анализе и софтверских пакета за предвиђање емисије експлозивних материја и убојних средстава, приликом сагоревања и детонације на отвореном простору...Modeling of environmental pollution and the negative impact of destruction of ordnance at the end of the life cycle and activation due to an accident, performed using the method of comparative numerical analysis and software packages for predicting the emission of explosive substances and ordnanace, during combustion and detonation in open space..

Open burning and open detonation of explosives. Prediction of pollutant emissions

The paper presents a complex analysis of the presence of various pollutants (CO2, CO, NO, NO2, CH4, TNMH, C6H6) in the vicinity of sites intended for open burning and open detonation of explosives. Previously obtained data (measured field data on a representative sample) regarding the emission factors of pollutants originating from different types of explosives have been used. To predict the atmospheric dispersion of reactive agents, the ADORA and ALOHA models were used. Comparative analysis was performed with computational and experimental data on the emission of detonation products using regression analysis of the obtained emission coefficients. The overall results show satisfactory values of correlation coefficients. The prediction power of used methods increased as follows: ADORA (the smallest error), ALOHA E/A (0.43) and ALOHA E/A 0.67

A square root pattern of changes in heart rate variability during the first year after circumferential pulmonary vein isolation for paroxysmal atrial fibrillation and their relation with long‑term arrhythmia recurrence

BACKGROUND An incidental lesion of the parasympathetic ganglia during circumferential pulmonary vein isolation (CPVI) may affect heart rate variability (HRV). AIMS We studied the pattern of changes in HRV parameters and the relationship between the 1‑year HRV change following CPVI and the recurrence of atrial fibrillation (AF). METHODS A total of 100 consecutive patients undergoing CPVI for paroxysmal AF were enrolled (mean [SD] age, 56 [11.2] years; 61 men). We measured HRV on the day before and after CPVI, and then at 1 month as well as 3, 6, and 12 months after CPVI using 24‑hour Holter monitoring. RESULTS During the median follow‑up of 33 months, 38 patients experienced the late recurrence of AF (LRAF). Compared with the pre‑CPVI values, HRV was significantly attenuated on day 1 after CPVI in all patients. However, at 3 to 6 months after CPVI, all HRV parameters remained significantly decreased in LRAF‑free patients but not in those with LRAF. The multivariate Cox analysis showed that early AF recurrence within the blanking period (hazard ratio [HR], 4.87; 95% CI, 2.44–9.69; P <0.001) and a change in the standard deviation of normal‑to‑normal intervals (SDNN) observed 3 months after ablation (HR, 0.99; 95% CI, 0.98–1; P = 0.01) were associated with LRAF. The cumulative LRAF freedom after CPVI was greater in patients with an SDNN reduction of more than 25 ms reported 3 months after ablation than in those with a reduction of 25 ms or lower (log‑rank P = 0.004). CONCLUSIONS Sustained parasympathetic denervation during 12 months after CPVI was a marker of successful CPVI, whereas a 3‑month post‑CPVI SDNN reduction of 25 ms or lower predicted LRAF

Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats

Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 +/- 11.66%) and gastroprotective activity (gastric damage score of 0.21 +/- 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (1.29 +/- 9 mu g/mL and 52 +/- 4 mu g/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an antiinflammatory and gastroprotective agent, Which has been based previously only on ethnopharmacological claims. Copyrigh