HIGH SCHOOLERS FOR HIGH SCHOOLERS AS SUPPORT TO STUDENTS\u27 SOCIAL-EMOTIONAL AND INTERPERSONAL (SEI) COMPETENCES ENFORCEMENT

It is with great interest that the modern society of today has been discussing the \u27society of knowledge\u27 and the \u27society of education\u27, putting great emphasis on the professional and educational role of the teacher and environment within the process of a life-long education of students. The project in question was set up to correspond with the idea of the comprehensive curricular reform of the Croatian education system together with the programme \u27School for Life\u27, and it aims to encourage and develop social-emotional as well as interpersonal (SEI) competences in students and teachers, taking into consideration that the competences in question have been proven to have a positive effect on students\u27 academic success and skills improvement, as well as on their general development. A secondary goal of the project was to present good practice examples with special attention paid to activities of prevention in a partner-school, with students as mediators. This research was undertaken as a part of the \u27High Schoolers for High Schoolers\u27 project, from October 2018 to April 2019, in form of a single visit to both schools, which included interactive workshops previously prepared by schools. The workshops were conducted by students mediators, that is four senior grade students from XV. gimnazija as members of a psychology-group, and five 11th-grade students mediators from Gimnazija Josipa Slavenskog in Čakovec. Forty-five 9th- and 11th-grade students from XV. gimnazija and seventy-five 9th- and 10th-grade students from Gimnazija Josipa Slavenskog participated in the project. A test sample consisted of four students mediators and fortyfive students participants from XV. gimnazija. As for the project evaluation, two short questionnaires were designed, depending on the role of the examinees in the project (student mediator or student participant), with a 5 point Likert scale to be completed at the end of a visit. A descriptive data analysis was conducted using the SPSS 20.0 system, and the process and content evaluation results show a stronger collaboration effect, as well as a stronger satisfaction level in terms of collaboration, in case of students mediators than in case of other students participants, in almost all estimated items. The results support further collaboration of this kind

Prikaz slučaja rijetkog unutarparenhimnog leiomioma dojke – dijagnostičke i patohistološke značajke

Leiomyomas are one of the rarest neoplasms of the breast. Intraparenchymal leiomyomas can present a diagnostic challenge, as they can resemble other benign, and more importantly, malignant lesions - especially leiomyosarcomas. Here we report a case of a 28-year old female patient with a palpable mass in the right upper quadrant of the right breast and present diagnostic and histopathological features, with special reference to magnetic resonance imaging.Leiomiomi su izrazito rijetki tumori dojke. Unutarparenhimni leiomiomi predstavljaju dijagnostički izazov, jer mogu nalikovati na druge dobroćudne i zloćudne tvorevine, posebice na leiomiosarkom. U radu je prikazan slučaj 28-godišnje žene s opipljivom masom u desnoj gornjoj četvrtini desne dojke. Opisane su dijagnostičke i patohistološke značajke nađenog tumora, s posebnim osvrtom na magnetsku rezonanciju

Numerical Simulation of Fatigue Crack Growth in Titanium Alloy Orthopaedic Plates

Biomaterials intended for orthopaedic plates manufacturing have much higher mechanical properties relative to the bone itself and still there are many cases where those plates fracture in service, with fatigue as the main failure mode. This causes problem with the healing process and requires that the patient undergoes another surgery. Experience and knowledge of the orthopaedic surgeon is one of the most important factors contributing to the frequency of fatigue failures. If incorrectly implanted, plates will be subjected to overloading from the start, which is convenient for crack initiation. One of the most commonly used biocompatible materials for internal bone fixation is α + β titanium alloy Ti-6Al-4V. Focus of this study was to simulate the behaviour of titanium alloy orthopaedic plates in the presence of cracks under four-point bending. The extended finite element method (XFEM) in ANSYS was employed for this purpose. Loads correspond to the ones occurring in human tibia during gait cycle for different body weights. Experimental investigation of tensile and fracture mechanics parameters of Ti-6Al-4V alloy was conducted on tensile testing machine and fractomate. Numerical simulation established the optimal geometry from remaining life point of view, indicating large differences between different geometries. Results also have shown that the remaining life of orthopaedic plates is strongly dependant on patient\u27s body weight (load) and that the relative differences in remaining life between compared plate geometries stay the same under different loads. Influence of corrosive environment of the human body was not taken into consideration

Numerical Simulation of Fatigue Crack Growth in Titanium Alloy Orthopaedic Plates

Biomaterials intended for orthopaedic plates manufacturing have much higher mechanical properties relative to the bone itself and still there are many cases where those plates fracture in service, with fatigue as the main failure mode. This causes problem with the healing process and requires that the patient undergoes another surgery. Experience and knowledge of the orthopaedic surgeon is one of the most important factors contributing to the frequency of fatigue failures. If incorrectly implanted, plates will be subjected to overloading from the start, which is convenient for crack initiation. One of the most commonly used biocompatible materials for internal bone fixation is alpha + beta titanium alloy Ti-6Al-4V. Focus of this study was to simulate the behaviour of titanium alloy orthopaedic plates in the presence of cracks under four-point bending. The extended finite element method (XFEM) in ANSYS was employed for this purpose. Loads correspond to the ones occurring in human tibia during gait cycle for different body weights. Experimental investigation of tensile and fracture mechanics parameters of Ti-6Al-4V alloy was conducted on tensile testing machine and fractomate. Numerical simulation established the optimal geometry from remaining life point of view, indicating large differences between different geometries. Results also have shown that the remaining life of orthopaedic plates is strongly dependant on patients body weight (load) and that the relative differences in remaining life between compared plate geometries stay the same under different loads. Influence of corrosive environment of the human body was not taken into consideration

Optical observations of NGC 1156 galaxy in narrowband [SII] and Hα filters

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Eksperimental evaluation of efficacy of the strategies for the persuasion resistance

U ovom članku izloženi su rezultati eksperimentalnog istraživanja strategija sticanja otpornosti na ubeđivanje. Cilj istraživanja bio je da se ispita efikasnost dve konkretne strategije kontraargumentovanja i obezvređivanja izvora i eventualna zavisnost efekata ovih strategija od kanala prijema poruke. Istraživanje se oslanja na modifikovanu eksperimentalnu paradigmu korišćenu u istraživanju Kameronove i saradnika (Cameron et al., 2002), sa namerom da se provere njihovi nalazi i to u situaciji prezentovanja poruke putem video, audio-zapisa ili pismenim putem. Ubeđujuća poruka proizvela je statistički značajne efekte - stav ispitanika prema prekidu trudnoće značajno je promenjen; ni jedna od strategija građenja otpornosti, međutim nije se pokazala efikasnom, kao što ni efekat promene stava nije zavisio od kanala prijema poruke.The present research took an experimental approach to examining strategies of resistance to persuasion. We tested the effects of two strategies (counterarguing and source derogation) and their relation to channel through which a message is received (print, audio and video). The experiment is based on modified experimental paradigm used in one previous research (Cameron et al, 2002) in order to retest their findings and examine the role of communication modality in inoculation. Persuasive message generated statistically significant effects- attitude towards abortion was significantly changed. Both resistance strategies, on the other hand, failed to elicit resistance and measured attitude change wasn't significantly related to communication channel

Comparative studies on osmosis based encapsulation of sodium diclofenac in porcine and outdated human erythrocyte ghosts

The objective of our study was to develop controlled drug delivery system based on erythrocyte ghosts for amphiphilic compound sodium diclofenac considering the differences between erythrocytes derived from two readily available materials - porcine slaughterhouse and outdated transfusion human blood. Starting erythrocytes, empty erythrocyte ghosts and diclofenac loaded ghosts were compared in terms of the encapsulation efficiency, drug releasing profiles, size distribution, surface charge, conductivity, surface roughness and morphology. The encapsulation of sodium diclofenac was performed by an osmosis based process - gradual hemolysis. During this process sodium diclofenac exerted mild and delayed antihemolytic effect and increased potassium efflux in porcine but not in outdated human erythrocytes. FTIR spectra revealed lack of any membrane lipid disorder and chemical reaction with sodium diclofenac in encapsulated ghosts. Outdated human erythrocyte ghosts with detected nanoscale damages and reduced ability to shrink had encapsulation efficiency of only 8%. On the other hand, porcine erythrocyte ghosts had encapsulation efficiency of 37% and relatively slow drug release rate. More preserved structure and functional properties of porcine erythrocytes related to their superior encapsulation and release performances, define them as more appropriate for the usage in sodium diclofenac encapsulation process

Synergistic effect of 17-allylamino-17-demethoxygeldanamycin with dehydroxymethylepoxyquinomicin on the human anaplastic thyroid carcinoma cell line KTC2

The use of targeted inhibitors has shown promise as an effective approach in cancer therapy. However, targeted therapies based only on one drug, such as 17-allylamino-17-demethoxygeldanamycin (17-AAG), have limited success, partly because cancer cells engage alternate pathways for survival and proliferation. In the present study, we evaluated whether dehydroxymethylepoxyquinomicin (DHMEQ), a nuclear factor ?B (NF-?B) inhibitor, can enhance the antitumor activities of 17-AAG, a 90 kDa heat shock protein (Hsp90) inhibitor, in the anaplastic thyroid cancer cell line KTC2. We examined the effect of combined drug treatment vs single drug treatment on cell survival. Isobologram analysis was performed to distinguish the additive vs synergistic effects of the drug combination. Western blotting was performed to investigate apoptosis markers: caspase 3, poly(ADP-ribose) polymerase-one (PARP-1), B-cell lymphoma-extra large (Bcl-XL), X-linked inhibitor of apoptosis (XIAP) and cellular inhibitor of apoptosis 2 (cIAP-2). Compared to monotherapy, the combined treatment enhanced growth-inhibitory effects in a synergistic manner and strongly potentiated apoptosis. These results demonstrate the first in vitro evidence that a combination of Hsp90 and NF-?B inhibitors is a more effective modality for inhibiting cell proliferation and survival in anaplastic thyroid carcinoma cells than either agent alone, warranting further investigations