3 research outputs found
Nature secondary quartzites of the island Bol’shoy Tyuters (Gulf of the Finland, Russia)
Territory Baltic shield is well understood and the identification of innovative geological formations rare stroke of luck. Thanks to the Russian Geographical Society in the summer of 2015 an integrated expedition to study the nature of the little-known islands of the Outer Gulf of Finland was carried out and found, much quartz rocks (SiO2 more than 90%) that compose most part of the island Bolhoy Tyuters. As a result of complex studies including petrogeochemical, microprobe, isotope, thermobarogeochemical investigations and chromatographic analysis of gases, it can be asserted that these rocks are secondary quartzites formed under the influence of carbon dioxide solutions. The presence of shadow structures of migmatites, as well as mineralogical features of quartzites, suggest that the initial rocks, on which secondary quartzites were formed, could be shales of the svecofennian complex. The temperature of homogenization of gas-liquid inclusions is 330-370°C, which indicates a high-temperature facies of secondary quartzites. The age of the dikes of the granite composition, which break through secondary quartzites, is close to 1660 and 1680 million years, which is somewhat older than the main phase of rapakivi granites (1650-1550 my) and coincides with the pre-Riphean weathering era, at the end of which the formation of the largest “type of disagreement” occurred. The formation of secondary quartzites of B. Tyuters, as well as for most classical manifestations of this type, we associate with the fluid-explosive activity of volcanoes preceded of rapakivi granites, whose products, in the form of basic and acidic lavas, were preserved as part of the Early Riphean strata located on the island Hogland. Considering the huge resources of these quartzites (more than 370 million tons), this manifestation is very promising for high purity quartz raw materials, close to the North-Western industrial area and St-Petersburg. The formation of a subhorizontal plane controlling the formation of a deposit of secondary quartzites and Early Riphean sediments and rapakivi granite intrusions, we associate with the tectonic activity of the marginal part of the Baltic Shield, known as the Polkanov lineament
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CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods
BackgroundThe Critical Assessment of Genome Interpretation (CAGI) aims to advance the state-of-the-art for computational prediction of genetic variant impact, particularly where relevant to disease. The five complete editions of the CAGI community experiment comprised 50 challenges, in which participants made blind predictions of phenotypes from genetic data, and these were evaluated by independent assessors.ResultsPerformance was particularly strong for clinical pathogenic variants, including some difficult-to-diagnose cases, and extends to interpretation of cancer-related variants. Missense variant interpretation methods were able to estimate biochemical effects with increasing accuracy. Assessment of methods for regulatory variants and complex trait disease risk was less definitive and indicates performance potentially suitable for auxiliary use in the clinic.ConclusionsResults show that while current methods are imperfect, they have major utility for research and clinical applications. Emerging methods and increasingly large, robust datasets for training and assessment promise further progress ahead