7 research outputs found
Healthy ageing in a multi-ethnic population: A descriptive cross-sectional analysis from the HELIUS study.
OBJECTIVE
We investigated ethnic health disparities in the Healthy Life in an Urban Setting multi-ethnic cohort using the multidimensional Healthy Ageing Score.
STUDY DESIGN
We conducted a cross-sectional analysis of the study baseline data (2011-2015) collected through questionnaires/physical examinations for 17,091 participants (54.8 % women, mean (SD) age = 44.5 (12.8) years) from South-Asian Surinamese (14.8 %), African Surinamese (20.5 %), Dutch (24.3 %), Moroccan (15.5 %), Turkish (14.9 %), and Ghanaian (10.1 %) origins, living in Amsterdam, the Netherlands.
MAIN OUTCOME MEASURES
We computed the Healthy Ageing Score developed in the Rotterdam Study, which has seven biopsychosocial domains: chronic diseases, mental health, cognitive function, physical function, pain, social support, and quality of life. That score was used to discern between healthy, moderate, and poor ageing. We explored differences in healthy ageing by ethnicity, sex, and age group using multinomial logistic regression.
RESULTS
The Healthy Ageing Score [overall: poor (69.0 %), moderate (24.8 %), and healthy (6.2 %)] differed between ethnicities and was poorer in women and after midlife (cut-off 45 years) across ethnicities (all p < 0.001). In the fully adjusted models in men and women, poor ageing (vs. healthy ageing) was highest in the South-Asian Surinamese [adjusted odds ratios (95 % confidence intervals)] [2.96 (2.24-3.90) and 6.88 (3.29-14.40), respectively] and Turkish [2.80 (2.11-3.73) and 7.10 (3.31-15.24), respectively] vs. Dutch, in the oldest [5.89 (3.62-9.60) and 13.17 (1.77-98.01), respectively] vs. youngest, and in the divorced [1.48 (1.10-2.01) and 2.83 (1.39-5.77), respectively] vs. married. Poor ageing was inversely associated with educational and occupational levels, mainly in men.
CONCLUSIONS
Compared with those of Dutch ethnic origin, ethnic minorities displayed less healthy ageing, which was more pronounced in women, before and after midlife, and was associated with sociodemographic factors
カゼインホスホペプチドの免疫調節素材としての評価と利用性の開発
The CD154–CD40 receptor complex
plays a pivotal role in
several inflammatory pathways. Attempts to inhibit the formation of
this complex have resulted in systemic side effects. Downstream inhibition
of the CD40 signaling pathway therefore seems a better way to ameliorate
inflammatory disease. To relay a signal, the CD40 receptor recruits
adapter proteins called tumor necrosis factor receptor-associated
factors (TRAFs). CD40–TRAF6 interactions are known to play
an essential role in several inflammatory diseases. We used <i>in silico</i>, <i>in vitro</i>, and <i>in vivo</i> experiments to identify and characterize compounds that block CD40–TRAF6
interactions. We present in detail our drug docking and optimization
pipeline and show how we used it to find lead compounds that reduce
inflammation in models of peritonitis and sepsis. These compounds
appear to be good leads for drug development, given the observed absence
of side effects and their demonstrated efficacy for peritonitis and
sepsis in mouse models